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Zhigang Yang
zgyang@whu.edu.cn
Chinese, English
Hubei
Wuhan University
Medical School
  • 2002-2006 Bachelor's Degree: Sichuan University, School of Chemistry
  • 2006-2011 PhD: Sichuan University, School of Chemistry
  • 2011-2013 Postdoctoral Researcher, Nanyang Technological University, Singapore
  • 2013-present Associate Professor, School of Pharmaceutical Sciences, Wuhan University
  • 2018 Second Prize, Young Teacher Teaching Competition, School of Pharmaceutical Sciences
  • 2020 Third Prize, Young Teacher Teaching Competition, School of Pharmaceutical Sciences
  • 2020 Laboratory Safety Knowledge Expert, Wuhan University
  • 2024 Second Prize, First Laboratory Safety Skills Competition, Wuhan University
Drug Chemistry
Drug Materials
  • Synthesis of gem-Difluorinated 2,3-Dihydrobenzofurans Using Freon-22 via [4+1] Annulation of Difluorocarbene and Antitumor Activity Evaluation, Qianying Zhou, Mi Huang, Yongcun Shen, Zhenling Chen, Liying Xu, and Zhigang Yang, 2024
  • TBAF-Mediated [3+1] Cycloaddition of Difluorocarbene to Access gem-Difluorinated 1,2-Diazetidine Analogues as Potent Anticancer Agents, Yuyin Mao, Na Li, Jie Liu, Zhong-Xing Jiang, and Zhigang Yang, 2023
  • Switchable Nucleophilic Site Enables Expedient Synthesis of CF3‑Containing Thiazoles and Allenes from 1,3-Enynes, Xiangyu Li, Na Li, Lan Yang, Rui Jiang, Yong He, Jian Shi, Zhong-Xing Jiang, and Zhigang Yang, 2023
  • Synthesis of SCF3-Substituted Sulfonium Ylides from Sulfonium Salts or α-Bromoacetic Esters, Yushan Xiao, Yimin Jia, Jinfeng Huang, Xiangyu Li, Zhiwen Zhou, Jing Zhang, Mou Jiang, Xin Zhou, Zhong-Xing Jiang, and Zhigang Yang, 2022
  • Synthesis of Difluorinated Heterocyclics through Metal-Free [8+1] and [4+1] Cycloaddition of Difluorocarbene, Yimin Jia, Yuan Yuan, Jinfeng Huang, Zhong-Xing Jiang, and Zhigang Yang, 2021
  • Halotrifluoromethylation of 1,3-Enynes: Access to Tetrasubstituted Allenes, Jinfeng Huang, Yimin Jia, Xiangyu Li, Jianli Duan, Zhong-Xing Jiang, and Zhigang Yang, 2021
  • Chlorotrifluoromethylthiolation of Sulfur Ylides for the Formation of Tetrasubstituted Trifluoromethylthiolated Alkenes, Na Wang, Yimin Jia, Hongmei Qin, Zhong-xing Jiang, and Zhigang Yang, 2020
  • F- −Free Deoxyhydrotrifluoromethylation of α-Keto Esters with Ph3P+CF2CO2-: Synthesis of α-CF3‑Substituted Esters, Ying Zheng, Yimin Jia, Yuan Yuan, Zhong-Xing Jiang, and Zhigang Yang, 2020
  • Practical and regioselective halo-trifluoromethylthiolation of sulfur ylides, Hongmei Qin, Yimin Jia, Na Wang, Zhong-Xing Jiang and Zhigang Yang, 2020
  • Synthesis of Branched Monodisperse Oligoethylene Glycols and 19F MRI-Traceable Biomaterials through Reductive Dimerization of Azides, Jing Zhang, Yuan Yuan, Yu Li, Hao Yang, Huaibin Zhang, Shizhen Chen, Xin Zhou, Zhigang Yang, and Zhong-Xing Jiang, 2020
  • Electrophilic chloro(ω-alkoxy)lation of alkenes employing 1-chloro-1,2-benziodoxol-3-one: facile synthesis of β-chloroethers, Yimin Jia, Long Chen, Huaibin Zhang, Ying Zheng, Zhong-Xing Jiang and Zhigang Yang, 2018
  • Fe2O3‑promoted intermolecular chlorotrifluoromethylthiolation of alkenes, Yimin Jia, Hongmei Qin, Na Wang, Zhong-Xing Jiang, and Zhigang Yang, 2018
  • Fe2O3-catalyzed Pummerer Rearrangement of Acyl Chlorides and Sulfoxides: Facile Synthesis of Alkylthiomethyl Ester, Haotian Xing, Long Chen, Yimin Jia, Zhongxing Jiang, Zhigang Yang, 2017
  • Amide bond-containing monodisperse polyethylene glycols beyond 10 000 Da, Zihong Wan, Yu Li, Shaowei Bo, Ming Gao, Xuemeng Wang, Kai Zeng, Xin Tao, Xuefei Li, Zhigang Yang, and Zhong-Xing Jiang, 2016
  • Copper-catalyzed intermolecular chloroazidation of α,β-unsaturated amides, Long Chen, Haotian Xing, Huaibin Zhang, Zhong-Xing Jiang and Zhigang Yang, 2016
  • Copper-Catalyzed Intermolecular Chloro- and Bromotrifluoromethylation of Alkenes, Mingyang Fu, Long Chen, Yongpeng Jiang, Zhong-Xing Jiang, and Zhigang Yang, 2016
  • Development of a Scalable Process for α-Amino-ω-methoxyl-dodecaethylene Glycol, Guiquan Xia, Yu Li, Zhigang Yang, and Zhong-Xing Jiang, 2015
  • Fluorous synthesis of mono-dispersed poly(ethylene glycols), Yu Li, Qi Guo, Xuefei Li, Hua Zhang, Fanghua Yu, Weijiang Yu, Guiquan Xia, Mingyang Fu, Zhigang Yang, Zhong-Xing Jiang, 2014
  • Palladium-Catalyzed, Asymmetric Mizoroki-Heck Reaction of Benzylic Electrophiles Using Phosphoramidites as Chiral Ligands, Zhigang Yang and Jianrong (Steve) Zhou, 2012
  • Asymmetric α-Amination of 4-Substituted Pyrazolones Catalyzed by a Chiral Gd(OTf)3/N,N′-Dioxide Complex: Highly Enantioselective Synthesis of 4-Amino-5-pyrazolone Derivatives, Zhigang Yang, Zhen Wang, Sha Bai, Xiaohua Liu, Lili Lin, Xiaoming Feng, 2011
  • Highly Enantioselective Synthesis of 3-Amino-2-oxindole Derivatives: Catalytic Asymmetric α-Amination of 3-Substituted 2-Oxindoles with a Chiral Scandium Complex, Zhigang Yang, Zhen Wang, Sha Bai, Ke Shen, Donghui Chen, Xiaohua Liu, Lili Lin, Xiaoming Feng, 2010
  • Highly Efficient Amine Organocatalysts Based on Bispidine for the Asymmetric Michael Addition of Ketones to Nitroolefins, Zhigang Yang, Jie Liu, Xiaohua Liu, Zhen Wang, Xiaoming Feng, Zhishan Su, Changwei Hu, 2008
Tumor Diagnosis Drug Design 19F Mri Drug Delivery Systems Fluorinated Drugs Biological Activity Synthesis High Efficiency Functional Materials Major Diseases

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