Professor | Tiehai Li | Asia Growth Partners

Name	Tiehai Li
Contact Information	tiehaili@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Tiehai Li

Contact Information

tiehaili@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2007-09--2012-06 PhD: Nankai University 2001-09--2005-06 Bachelor: Hubei Normal University
Work Experience	2019-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher 2015-04~2019-09 - University of Georgia, USA - Postdoctoral Researcher 2012-08~2015-02 - Georgia State University, USA - Postdoctoral Researcher 2007-09~2012-06 - Nankai University - PhD Student 2001-09~2005-06 - Hubei Normal University - Bachelor Student
Awards	Shanghai Pujiang Talent Program (2020): Provincial Level Excellent Poster Award at National Medicinal Chemistry Conference (2011): Other Guanghua Education Fund Second Prize (2010): Institute Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2007-09--2012-06 PhD: Nankai University
2001-09--2005-06 Bachelor: Hubei Normal University

Work Experience

2019-09~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
2015-04~2019-09 - University of Georgia, USA - Postdoctoral Researcher
2012-08~2015-02 - Georgia State University, USA - Postdoctoral Researcher
2007-09~2012-06 - Nankai University - PhD Student
2001-09~2005-06 - Hubei Normal University - Bachelor Student

Awards

Shanghai Pujiang Talent Program (2020): Provincial Level
Excellent Poster Award at National Medicinal Chemistry Conference (2011): Other
Guanghua Education Fund Second Prize (2010): Institute Level

Areas of Focus	Glycochemistry Glycobiology Glycopharmacology
Publications	Stereoconvergent and Chemoenzymatic Synthesis of Tumor-Associated Glycolipid Disialosyl Globopentaosylceramide for Probing the Binding Affinity of Siglec-7, Tiehai Li, 2024 Divergent Enzymatic Assembly of a Comprehensive 64-Membered IgG N-Glycan Library for Functional Glycomics, Tiehai Li, 2023 Mapping the Acetylamino and Carboxyl Groups on Glycans by Engineered β-Hemolysin Nanopores, Tiehai Li, 2023 Convergent Synthesis and Anti-Pancreatic Cancer Cell Growth Activity of a Highly Branched Heptadecasaccharide from Carthamus tinctorius, Tiehai Li, 2022 Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase, Tiehai Li, 2022 Chemoenzymatic Synthesis of Campylobacter jejuni Lipo-oligosaccharide Core Domains to Examine Guillain–Barré Syndrome Serum Antibody Specificities, Tiehai Li, 2021 Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans, Tiehai Li, 2021 Protecting-Group-Controlled Enzymatic Glycosylation of Oligo-N-Acetyllactosamine Derivatives, Tiehai Li, 2019 An automated platform for the enzyme-mediated assembly of complex oligosaccharides, Tiehai Li, 2019 Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins, Tiehai Li, 2018 Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri-, and Tetra-Antennary N-Glycans from a Common Precursor, Tiehai Li, 2017 Divergent Chemoenzymatic Synthesis of Asymmetrical-Core-Fucosylated and Core-Unmodified N-Glycans, Tiehai Li, 2016 Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux, Tiehai Li, 2014 O-GlcNAcase Inhibitors, Tiehai Li, 2011 Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as beta-glucosidase inhibitors, Tiehai Li, 2011 O-GlcNAcase Inhibitors, Tiehai Li, 2011 An improved strategy to synthesize N-butyl-1-deoxynojirimycin, Tiehai Li, 2011

Areas of Focus

Glycochemistry
Glycobiology
Glycopharmacology

Publications

Stereoconvergent and Chemoenzymatic Synthesis of Tumor-Associated Glycolipid Disialosyl Globopentaosylceramide for Probing the Binding Affinity of Siglec-7, Tiehai Li, 2024
Divergent Enzymatic Assembly of a Comprehensive 64-Membered IgG N-Glycan Library for Functional Glycomics, Tiehai Li, 2023
Mapping the Acetylamino and Carboxyl Groups on Glycans by Engineered β-Hemolysin Nanopores, Tiehai Li, 2023
Convergent Synthesis and Anti-Pancreatic Cancer Cell Growth Activity of a Highly Branched Heptadecasaccharide from Carthamus tinctorius, Tiehai Li, 2022
Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase, Tiehai Li, 2022
Chemoenzymatic Synthesis of Campylobacter jejuni Lipo-oligosaccharide Core Domains to Examine Guillain–Barré Syndrome Serum Antibody Specificities, Tiehai Li, 2021
Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans, Tiehai Li, 2021
Protecting-Group-Controlled Enzymatic Glycosylation of Oligo-N-Acetyllactosamine Derivatives, Tiehai Li, 2019
An automated platform for the enzyme-mediated assembly of complex oligosaccharides, Tiehai Li, 2019
Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins, Tiehai Li, 2018
Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri-, and Tetra-Antennary N-Glycans from a Common Precursor, Tiehai Li, 2017
Divergent Chemoenzymatic Synthesis of Asymmetrical-Core-Fucosylated and Core-Unmodified N-Glycans, Tiehai Li, 2016
Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux, Tiehai Li, 2014
O-GlcNAcase Inhibitors, Tiehai Li, 2011
Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as beta-glucosidase inhibitors, Tiehai Li, 2011
O-GlcNAcase Inhibitors, Tiehai Li, 2011
An improved strategy to synthesize N-butyl-1-deoxynojirimycin, Tiehai Li, 2011

Glycochemistry Carbohydrates Synthesis Enzymatic Glycans Glycoproteins Glycolipids Glycosylation Biological Activity Drug Development

Zhigang Yang - Wuhan University

Wenhu Duan - University of Chinese Academy of Sciences

Shenghong Li - University of Chinese Academy of Sciences

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