Professor | 李铁海 | 数字化转型顾问

Name	李铁海
Contact Information	tiehaili@simm.ac.cn
Language ability	中文, 英语
Province	上海

Name

李铁海

Contact Information

tiehaili@simm.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2007-09--2012-06 博士: 南开大学 2001-09--2005-06 学士: 湖北师范大学
Work Experience	2019-09~现在 - 中国科学院上海药物研究所 - 研究员 2015-04~2019-09 - 美国乔治亚大学 - 博士后 2012-08~2015-02 - 美国佐治亚州立大学 - 博士后 2007-09~2012-06 - 南开大学 - 博士生 2001-09~2005-06 - 湖北师范大学 - 学士生
Awards	上海市浦江人才计划 (2020): 省级全国药物化学学术会议优秀墙报奖 (2011): 其他光华教育基金二等奖 (2010): 研究所（学校）

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2007-09--2012-06 博士: 南开大学
2001-09--2005-06 学士: 湖北师范大学

Work Experience

2019-09~现在 - 中国科学院上海药物研究所 - 研究员
2015-04~2019-09 - 美国乔治亚大学 - 博士后
2012-08~2015-02 - 美国佐治亚州立大学 - 博士后
2007-09~2012-06 - 南开大学 - 博士生
2001-09~2005-06 - 湖北师范大学 - 学士生

Awards

上海市浦江人才计划 (2020): 省级
全国药物化学学术会议优秀墙报奖 (2011): 其他
光华教育基金二等奖 (2010): 研究所（学校）

Areas of Focus	糖化学糖化学生物学糖药物学
Publications	Stereoconvergent and Chemoenzymatic Synthesis of Tumor-Associated Glycolipid Disialosyl Globopentaosylceramide for Probing the Binding Affinity of Siglec-7, 李铁海, 2024 Divergent Enzymatic Assembly of a Comprehensive 64-Membered IgG N-Glycan Library for Functional Glycomics, 李铁海, 2023 Mapping the Acetylamino and Carboxyl Groups on Glycans by Engineered β-Hemolysin Nanopores, 李铁海, 2023 Convergent Synthesis and Anti-Pancreatic Cancer Cell Growth Activity of a Highly Branched Heptadecasaccharide from Carthamus tinctorius, 李铁海, 2022 Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase, 李铁海, 2022 Chemoenzymatic Synthesis of Campylobacter jejuni Lipo-oligosaccharide Core Domains to Examine Guillain–Barré Syndrome Serum Antibody Specificities, 李铁海, 2021 Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans, 李铁海, 2021 Protecting-Group-Controlled Enzymatic Glycosylation of Oligo-N-Acetyllactosamine Derivatives, 李铁海, 2019 An automated platform for the enzyme-mediated assembly of complex oligosaccharides, 李铁海, 2019 Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins, 李铁海, 2018 Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri-, and Tetra-Antennary N-Glycans from a Common Precursor, 李铁海, 2017 Divergent Chemoenzymatic Synthesis of Asymmetrical-Core-Fucosylated and Core-Unmodified N-Glycans, 李铁海, 2016 Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux, 李铁海, 2014 O-GlcNAcase Inhibitors, 李铁海, 2011 Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as beta-glucosidase inhibitors, 李铁海, 2011 O-GlcNAcase Inhibitors, 李铁海, 2011 An improved strategy to synthesize N-butyl-1-deoxynojirimycin, 李铁海, 2011

Areas of Focus

糖化学
糖化学生物学
糖药物学

Publications

Stereoconvergent and Chemoenzymatic Synthesis of Tumor-Associated Glycolipid Disialosyl Globopentaosylceramide for Probing the Binding Affinity of Siglec-7, 李铁海, 2024
Divergent Enzymatic Assembly of a Comprehensive 64-Membered IgG N-Glycan Library for Functional Glycomics, 李铁海, 2023
Mapping the Acetylamino and Carboxyl Groups on Glycans by Engineered β-Hemolysin Nanopores, 李铁海, 2023
Convergent Synthesis and Anti-Pancreatic Cancer Cell Growth Activity of a Highly Branched Heptadecasaccharide from Carthamus tinctorius, 李铁海, 2022
Integrated Chemoenzymatic Approach to Streamline the Assembly of Complex Glycopeptides in the Liquid Phase, 李铁海, 2022
Chemoenzymatic Synthesis of Campylobacter jejuni Lipo-oligosaccharide Core Domains to Examine Guillain–Barré Syndrome Serum Antibody Specificities, 李铁海, 2021
Diversity-Oriented Chemoenzymatic Synthesis of Sulfated and Nonsulfated Core 2 O-GalNAc Glycans, 李铁海, 2021
Protecting-Group-Controlled Enzymatic Glycosylation of Oligo-N-Acetyllactosamine Derivatives, 李铁海, 2019
An automated platform for the enzyme-mediated assembly of complex oligosaccharides, 李铁海, 2019
Multiplex glycan bead array for high throughput and high content analyses of glycan binding proteins, 李铁海, 2018
Chemoenzymatic Approach for the Preparation of Asymmetric Bi-, Tri-, and Tetra-Antennary N-Glycans from a Common Precursor, 李铁海, 2017
Divergent Chemoenzymatic Synthesis of Asymmetrical-Core-Fucosylated and Core-Unmodified N-Glycans, 李铁海, 2016
Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux, 李铁海, 2014
O-GlcNAcase Inhibitors, 李铁海, 2011
Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as beta-glucosidase inhibitors, 李铁海, 2011
O-GlcNAcase Inhibitors, 李铁海, 2011
An improved strategy to synthesize N-butyl-1-deoxynojirimycin, 李铁海, 2011

糖化学碳水化合物合成酶促糖类糖蛋白糖脂糖基化生物活性药物开发

曾臣 - 南方科技大学

Area of Focus
糖化学 | 糖蛋白 | 多肽 | 药物 | 有机 | 小分子 | 探针 | 合成 | 生物化学 | 化学生物学

杨志刚 - 武汉大学

刘鹏 - 武汉大学

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