Professor | Zheng Liu | Asia Growth Partners

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Name	Zheng Liu
Contact Information	ZhengL23@whu.edu.cn
Language ability	Chinese, English
Province	Hubei

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Name

Zheng Liu

Contact Information

ZhengL23@whu.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Wuhan University
Faculty	Medical School
Academic Background & Achievements	2006.09--2010.07 Bachelor of Science: Anhui Agricultural University, School of Life Sciences 2010.09--2015.06 Doctor of Science: University of Science and Technology of China, School of Life Sciences
Work Experience	2017.04--2021.11 Postdoctoral Researcher, School of Medicine, University of California, Irvine 2023.04 - Present Distinguished Associate Researcher, School of Pharmaceutical Sciences, Wuhan University

University/Lab Affiliation and Title

Wuhan University

Faculty

Medical School

Academic Background & Achievements

2006.09--2010.07 Bachelor of Science: Anhui Agricultural University, School of Life Sciences
2010.09--2015.06 Doctor of Science: University of Science and Technology of China, School of Life Sciences

Work Experience

2017.04--2021.11 Postdoctoral Researcher, School of Medicine, University of California, Irvine
2023.04 - Present Distinguished Associate Researcher, School of Pharmaceutical Sciences, Wuhan University

Areas of Focus	Pathogenic microorganisms and host interactions and targeted drug research
Publications	Structure basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, Liu, Z., Lee, P. G., Krez, N., Lam, K. H., Liu, H., Przykopanski, A., Chen, P., Yao, G., Zhang, S., Tremblay, J. M., Perry, K., Shoemaker, C. B., Rummel, A., Dong, M. & Jin, R., 2023 Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R., 2021 Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M. & Li, X., 2014 Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M. & Jin, R., 2018 Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M. & Jin, R., 2021 Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R., 2019 Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition, Chen, B., Liu, Z., Perry, K. & Jin, R., 2022 Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R., 2019 Structure-based design of Cdc42 effector interaction inhibitors for the treatment of cancer, Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., Serra, M. A. L., Brindani, N., Sala, G. L., Manigrasso, J., Arencibia, J. M., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., Jin, R., Liu, Z., Chen, C. F., Edwards, R., Hughes, C. C. W., Vivo, M. D. & Ganesan, A. K., 2022 Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M. & Li, X., 2015

Areas of Focus

Pathogenic microorganisms and host interactions and targeted drug research

Publications

Structure basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, Liu, Z., Lee, P. G., Krez, N., Lam, K. H., Liu, H., Przykopanski, A., Chen, P., Yao, G., Zhang, S., Tremblay, J. M., Perry, K., Shoemaker, C. B., Rummel, A., Dong, M. & Jin, R., 2023
Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R., 2021
Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M. & Li, X., 2014
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M. & Jin, R., 2018
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M. & Jin, R., 2021
Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R., 2019
Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition, Chen, B., Liu, Z., Perry, K. & Jin, R., 2022
Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R., 2019
Structure-based design of Cdc42 effector interaction inhibitors for the treatment of cancer, Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., Serra, M. A. L., Brindani, N., Sala, G. L., Manigrasso, J., Arencibia, J. M., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., Jin, R., Liu, Z., Chen, C. F., Edwards, R., Hughes, C. C. W., Vivo, M. D. & Ganesan, A. K., 2022
Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M. & Li, X., 2015

Pathogens Microorganisms Host Interactions Drug Research Targeted Therapy Biomedical Science Molecular Biology Pharmacology Disease Mechanisms Therapeutic Strategies

Xinran Li - Wuhan University

Yuliang Feng - Southern University of Science and Technology

Ji Yang - Southern University of Science and Technology

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