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Zheng Liu
Medical School
Wuhan University
Hubei
Language: Chinese, English
Pathogens
Microorganisms
Host Interactions
Drug Research
Targeted Therapy
Biomedical Science
Molecular Biology
Pharmacology
Disease Mechanisms
Therapeutic Strategies
Areas of Focus
- Pathogenic microorganisms and host interactions and targeted drug research
Work Experience
- 2017.04--2021.11 Postdoctoral Researcher, School of Medicine, University of California, Irvine
- 2023.04 - Present Distinguished Associate Researcher, School of Pharmaceutical Sciences, Wuhan University
Academic Background & Achievements
- 2006.09--2010.07 Bachelor of Science: Anhui Agricultural University, School of Life Sciences
- 2010.09--2015.06 Doctor of Science: University of Science and Technology of China, School of Life Sciences
Publications
- Structure basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, Liu, Z., Lee, P. G., Krez, N., Lam, K. H., Liu, H., Przykopanski, A., Chen, P., Yao, G., Zhang, S., Tremblay, J. M., Perry, K., Shoemaker, C. B., Rummel, A., Dong, M. & Jin, R., 2023
- Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R., 2021
- Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M. & Li, X., 2014
- Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M. & Jin, R., 2018
- Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M. & Jin, R., 2021
- Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R., 2019
- Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition, Chen, B., Liu, Z., Perry, K. & Jin, R., 2022
- Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R., 2019
- Structure-based design of Cdc42 effector interaction inhibitors for the treatment of cancer, Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., Serra, M. A. L., Brindani, N., Sala, G. L., Manigrasso, J., Arencibia, J. M., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., Jin, R., Liu, Z., Chen, C. F., Edwards, R., Hughes, C. C. W., Vivo, M. D. & Ganesan, A. K., 2022
- Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M. & Li, X., 2015
