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刘峥
Medical School
武汉大学
湖北省
Language: 中文, 英语
病原体
微生物
宿主互作
药物研究
靶向治疗
生物医学
分子生物学
药理学
疾病机制
治疗策略
Areas of Focus
- 病原微生物与宿主互作及靶向药物研究
Work Experience
- 2017.04--2021.11 加州大学欧文分校 医学院，博士后
- 2023.04 - 至今 武汉大学 药学院, 特聘副研究员
Academic Background & Achievements
- 2006.09--2010.07 安徽农业大学 生命科学学院，理学学士
- 2010.09--2015.06 中国科学技术大学 生命科学学院，理学博士
Publications
- Structure basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, Liu, Z., Lee, P. G., Krez, N., Lam, K. H., Liu, H., Przykopanski, A., Chen, P., Yao, G., Zhang, S., Tremblay, J. M., Perry, K., Shoemaker, C. B., Rummel, A., Dong, M. & Jin, R., 2023
- Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R., 2021
- Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M. & Li, X., 2014
- Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M. & Jin, R., 2018
- Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M. & Jin, R., 2021
- Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R., 2019
- Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition, Chen, B., Liu, Z., Perry, K. & Jin, R., 2022
- Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R., 2019
- Structure-based design of Cdc42 effector interaction inhibitors for the treatment of cancer, Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., Serra, M. A. L., Brindani, N., Sala, G. L., Manigrasso, J., Arencibia, J. M., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., Jin, R., Liu, Z., Chen, C. F., Edwards, R., Hughes, C. C. W., Vivo, M. D. & Ganesan, A. K., 2022
- Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M. & Li, X., 2015
