Professor | 刘峥 | 数字化转型顾问

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Name	刘峥
Contact Information	ZhengL23@whu.edu.cn
Language ability	中文, 英语
Province	湖北省

Upload Avatar (500 x 500)

Name

刘峥

Contact Information

ZhengL23@whu.edu.cn

Language ability

中文, 英语

Province

湖北省

University/Lab Affiliation and Title	武汉大学
Faculty	Medical School
Academic Background & Achievements	2006.09--2010.07 安徽农业大学生命科学学院，理学学士 2010.09--2015.06 中国科学技术大学生命科学学院，理学博士
Work Experience	2017.04--2021.11 加州大学欧文分校医学院，博士后 2023.04 - 至今武汉大学药学院, 特聘副研究员

University/Lab Affiliation and Title

武汉大学

Faculty

Medical School

Academic Background & Achievements

2006.09--2010.07 安徽农业大学生命科学学院，理学学士
2010.09--2015.06 中国科学技术大学生命科学学院，理学博士

Work Experience

2017.04--2021.11 加州大学欧文分校医学院，博士后
2023.04 - 至今武汉大学药学院, 特聘副研究员

Areas of Focus	病原微生物与宿主互作及靶向药物研究
Publications	Structure basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, Liu, Z., Lee, P. G., Krez, N., Lam, K. H., Liu, H., Przykopanski, A., Chen, P., Yao, G., Zhang, S., Tremblay, J. M., Perry, K., Shoemaker, C. B., Rummel, A., Dong, M. & Jin, R., 2023 Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R., 2021 Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M. & Li, X., 2014 Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M. & Jin, R., 2018 Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M. & Jin, R., 2021 Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R., 2019 Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition, Chen, B., Liu, Z., Perry, K. & Jin, R., 2022 Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R., 2019 Structure-based design of Cdc42 effector interaction inhibitors for the treatment of cancer, Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., Serra, M. A. L., Brindani, N., Sala, G. L., Manigrasso, J., Arencibia, J. M., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., Jin, R., Liu, Z., Chen, C. F., Edwards, R., Hughes, C. C. W., Vivo, M. D. & Ganesan, A. K., 2022 Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M. & Li, X., 2015

Areas of Focus

病原微生物与宿主互作及靶向药物研究

Publications

Structure basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, Liu, Z., Lee, P. G., Krez, N., Lam, K. H., Liu, H., Przykopanski, A., Chen, P., Yao, G., Zhang, S., Tremblay, J. M., Perry, K., Shoemaker, C. B., Rummel, A., Dong, M. & Jin, R., 2023
Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R., 2021
Crystal structure of DnaT84-153-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M. & Li, X., 2014
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Chen, P., Tao, L., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M. & Jin, R., 2018
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Chen, P., Zeng, J., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, R., Huang, L., Dong, M. & Jin, R., 2021
Structure of the full-length Clostridium difficile toxin B, Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R., 2019
Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition, Chen, B., Liu, Z., Perry, K. & Jin, R., 2022
Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R., 2019
Structure-based design of Cdc42 effector interaction inhibitors for the treatment of cancer, Jahid, S., Ortega, J. A., Vuong, L. M., Acquistapace, I. M., Hachey, S. J., Flesher, J. L., Serra, M. A. L., Brindani, N., Sala, G. L., Manigrasso, J., Arencibia, J. M., Bertozzi, S. M., Summa, M., Bertorelli, R., Armirotti, A., Jin, R., Liu, Z., Chen, C. F., Edwards, R., Hughes, C. C. W., Vivo, M. D. & Ganesan, A. K., 2022
Crystal and EM structures of human phosphoribosyl pyrophosphate synthase I (PRS1) provide novel insights into the disease-associated mutations, Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G., Teng, M. & Li, X., 2015

病原体微生物宿主互作药物研究靶向治疗生物医学分子生物学药理学疾病机制治疗策略

冯宇亮 - 南方科技大学

季洋 - 南方科技大学

李婉秋 - 南方科技大学

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