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Xue Gao
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
Tumor Metabolism
Metabolic Reprogramming
Molecular Targets
Signal Regulation
Epigenetic Regulation
Tumor Microenvironment
Immunotherapy
Endoplasmic Reticulum
Tumor Development
Tumor Therapy
Areas of Focus
- Regulation mechanisms of tumor metabolic reprogramming and identification of molecular targets based on tumor metabolic vulnerabilities
- New functions of tumor metabolites: a) Signal regulatory functions of metabolites; b) Epigenetic regulatory roles of metabolites; c) Interaction between metabolites and tumor microenvironment and its impact on tumor immunotherapy
- Metabolic regulation of organelles and tumors: Role of endoplasmic reticulum metabolism in tumor occurrence, development, metastasis, and its application in tumor therapy
Work Experience
- 2023.11-present - Fudan University - Junior Researcher
- 2022.10-2023.09 - University of Michigan Medical School - Research Lab Specialist Lead
- 2020.09-2022.08 - University of Chicago Medical School - Research Assistant Professor
- 2016.10-2020.08 - Emory University - Postdoctoral Researcher
Academic Background & Achievements
- 2011.09-2016.06 Ph.D. in Biochemistry and Molecular Biology: Fudan University
- 2007.09-2011.06 B.Sc. in Biotechnology: Northeast Normal University
Publications
- Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity, Fan H, Xia S, Xiang J, Li Y, Ross MO, Lim SA, Yang F, Tu J, Xie L, Dougherty U, Zhang FQ, Zheng Z, Zhang R, Wu R, Dong L, Su R, Chen X, Althaus T, Riedell PA, Jonker PB, Muir A, Lesinski GB, Rafiq S, Dhodapkar MV, Stock W, Odenike O, Patel AA, Opferman J, Tsuji T, Matsuzaki J, Shah H, Faubert B, Elf SE, Layden B, Bissonnette BM, He YY, Kline J, Mao H, Odunsi K, Gao X, Chi H, He C, Chen J, 2023
- Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells, Zhang R, Chen D, Fan H, Wu R, Tu J, Zhang FQ, Wang M, Zheng H, Qu CK, Elf SE, Faubert B, He YY, Bissonnette MB, Gao X, DeBerardinis RJ, Chen J, 2022
- Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation, Gao X, Liu Y, Li Y, Fan H, Wu R, Zhang R, Faubert B, He YY, Bissonnette MB, Xia S, Chen D, Mao H, Boggon TJ, Chen J, 2022
- Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells, Chen D, Xia S, Zhang R, Li Y, Famulare CA, Fan H, Wu R, Wang M, Zhu AC, Elf SE, Su R, Dong L, Arellano M, Blum WG, Mao H, Lonial S, Stock W, Odenike O, Le Beau M, Boggon TJ, He C, Chen J, Gao X, Levine RL, Chen J, 2021
- gamma-6-Phosphogluconolactone, a Byproduct of the Oxidative Pentose Phosphate Pathway, Contributes to AMPK Activation through Inhibition of PP2A, Gao X, Zhao L, Liu S, Li Y, Xia S, Chen D, Wang M, Wu S, Dai Q, Vu H, Zacharias L, DeBerardinis R, Lim E, Metallo C, Boggon TJ, Lonial S, Lin R, Mao H, Pan Y, Shan C, Chen J, 2019
- Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia, Gao X, Lin SH, Ren F, Li JT, Chen JJ, Yao CB, Yang HB, Jiang SX, Yan GQ, Wang D, Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang PY, Lei QY, 2016
Awards
- 2022 - National Overseas High-Level Talent Program (Youth)
- 2022 - Shanghai Youth Talent Program
- 2015 - Ministry of Education - Second Prize in Natural Science Award (7th contributor)
- 2012-2013 - Fudan University - Excellent Ph.D. Student Scholarship (First Prize)
- 2012-2013 - Fudan University - Guanghua Scholarship
- 2011 - Northeast Normal University - Outstanding Graduate
- 2007-2008 - Northeast Normal University - National Scholarship
