Upload Avatar (500 x 500)
Mingfang Lu
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
Anti-Infective Immunity
Regulation
Mechanisms
Pulmonary Immunity
Intestinal Immunity
Mucosal Immunity
Innate Immune Response
Metabolic Diseases
Macrophage Metabolism
Reprogramming
Areas of Focus
- Regulatory mechanisms of anti-infective immunity
- Pulmonary and intestinal mucosal immunity
- Innate immune response and metabolic diseases
- Macrophage metabolism and reprogramming
Work Experience
- 1996.08—1996.12 - Fudan University, Basic Medical College - Teaching Assistant in Pharmacology
- 2003.11—2006.02 - University of Texas Southwestern Medical Center - Postdoctoral Fellow in Infectious Diseases
- 2006.03—2009.02 - University of Texas Southwestern Medical Center - Lecturer in Infectious Diseases
- 2009.03—2013.10 - National Institutes of Health (NIH, NIAID) - Staff Scientist
- 2013.11—Present - Fudan University, Basic Medical College - Professor in Immunology
Academic Background & Achievements
- 1988.09—1993.07 Bachelor's in Clinical Medicine: Shanghai Medical College, Fudan University
- 1993.09—1996.07 Master's in Pharmacology: Basic Medical College, Fudan University
- 1998.08—2003.10 Ph.D. in Immunology: University of Texas Southwestern Medical Center
Publications
- A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice, Zou, B., M. Goodwin, D. Saleem, W. Jiang, J. Tang, Y. Chu, R.S. Munford, and M. Lu, 2021
- A host lipase prevents lipopolysaccharide-induced foam cell formation, Feng, J., W. Jiang, X. Cheng, B. Zou, A. Varley, T. Liu, G. Qian, W. Zeng, J. Tang, Q. Zhao, Y. Chu, Y. Wei, X. Li, R. Munford, and M. Lu, 2021
- Extracellular Acidity Reprograms Macrophage Metabolism and Innate Responsiveness, Jiang, W., J. Le, P.Y. Wang, X. Cheng, M. Smelkinson, W. Dong, C. Yang, Y. Chu, P.M. Hwang, R.S. Munford, and M. Lu, 2021
- LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma, Qian, G., W. Jiang, B. Zou, J. Feng, X. Cheng, J. Gu, T. Chu, C. Niu, R. He, Y. Chu, and M. Lu, 2018
- Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury, Zou, B., W. Jiang, H. Han, J. Li, W. Mao, Z. Tang, Q. Yang, G. Qian, J. Qian, W. Zeng, J. Gu, T. Chu, N. Zhu, W. Zhang, D. Yan, R. He, Y. Chu, and M. Lu, 2017
- Persistently active microbial molecules prolong innate immune tolerance in vivo, Lu, M., A.W. Varley, and R.S. Munford, 2013
- The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo, Lu, M., and R.S. Munford, 2011
- Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection, Lu, M., A.W. Varley, S. Ohta, J. Hardwick, and R.S. Munford, 2008
- Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria, Lu, M., M. Zhang, A. Takashima, J. Weiss, M.A. Apicella, X.H. Li, D. Yuan, and R.S. Munford, 2005
- Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells, Lu, M., M. Zhang, R.L. Kitchens, S. Fosmire, A. Takashima, and R.S. Munford, 2003
Awards
- Young Scientist Award (2004): 8th International Congress on Innate Immunity and Endotoxins, Kyoto, Japan
- NIH Performance Award (2009-2013): United States
- Outstanding Young Paper Award (2014): Shanghai Immunology Society Annual Meeting, Shanghai, China
- Excellence Award (2018): Basic Medical College, Fudan University
