Professor | Mingfang Lu | Asia Growth Partners

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Name	Mingfang Lu
Contact Information	mingfanglu@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Mingfang Lu

Contact Information

mingfanglu@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1988.09—1993.07 Bachelor's in Clinical Medicine: Shanghai Medical College, Fudan University 1993.09—1996.07 Master's in Pharmacology: Basic Medical College, Fudan University 1998.08—2003.10 Ph.D. in Immunology: University of Texas Southwestern Medical Center
Work Experience	1996.08—1996.12 - Fudan University, Basic Medical College - Teaching Assistant in Pharmacology 2003.11—2006.02 - University of Texas Southwestern Medical Center - Postdoctoral Fellow in Infectious Diseases 2006.03—2009.02 - University of Texas Southwestern Medical Center - Lecturer in Infectious Diseases 2009.03—2013.10 - National Institutes of Health (NIH, NIAID) - Staff Scientist 2013.11—Present - Fudan University, Basic Medical College - Professor in Immunology
Awards	Young Scientist Award (2004): 8th International Congress on Innate Immunity and Endotoxins, Kyoto, Japan NIH Performance Award (2009-2013): United States Outstanding Young Paper Award (2014): Shanghai Immunology Society Annual Meeting, Shanghai, China Excellence Award (2018): Basic Medical College, Fudan University

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1988.09—1993.07 Bachelor's in Clinical Medicine: Shanghai Medical College, Fudan University
1993.09—1996.07 Master's in Pharmacology: Basic Medical College, Fudan University
1998.08—2003.10 Ph.D. in Immunology: University of Texas Southwestern Medical Center

Work Experience

1996.08—1996.12 - Fudan University, Basic Medical College - Teaching Assistant in Pharmacology
2003.11—2006.02 - University of Texas Southwestern Medical Center - Postdoctoral Fellow in Infectious Diseases
2006.03—2009.02 - University of Texas Southwestern Medical Center - Lecturer in Infectious Diseases
2009.03—2013.10 - National Institutes of Health (NIH, NIAID) - Staff Scientist
2013.11—Present - Fudan University, Basic Medical College - Professor in Immunology

Awards

Young Scientist Award (2004): 8th International Congress on Innate Immunity and Endotoxins, Kyoto, Japan
NIH Performance Award (2009-2013): United States
Outstanding Young Paper Award (2014): Shanghai Immunology Society Annual Meeting, Shanghai, China
Excellence Award (2018): Basic Medical College, Fudan University

Areas of Focus	Regulatory mechanisms of anti-infective immunity Pulmonary and intestinal mucosal immunity Innate immune response and metabolic diseases Macrophage metabolism and reprogramming
Publications	A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice, Zou, B., M. Goodwin, D. Saleem, W. Jiang, J. Tang, Y. Chu, R.S. Munford, and M. Lu, 2021 A host lipase prevents lipopolysaccharide-induced foam cell formation, Feng, J., W. Jiang, X. Cheng, B. Zou, A. Varley, T. Liu, G. Qian, W. Zeng, J. Tang, Q. Zhao, Y. Chu, Y. Wei, X. Li, R. Munford, and M. Lu, 2021 Extracellular Acidity Reprograms Macrophage Metabolism and Innate Responsiveness, Jiang, W., J. Le, P.Y. Wang, X. Cheng, M. Smelkinson, W. Dong, C. Yang, Y. Chu, P.M. Hwang, R.S. Munford, and M. Lu, 2021 LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma, Qian, G., W. Jiang, B. Zou, J. Feng, X. Cheng, J. Gu, T. Chu, C. Niu, R. He, Y. Chu, and M. Lu, 2018 Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury, Zou, B., W. Jiang, H. Han, J. Li, W. Mao, Z. Tang, Q. Yang, G. Qian, J. Qian, W. Zeng, J. Gu, T. Chu, N. Zhu, W. Zhang, D. Yan, R. He, Y. Chu, and M. Lu, 2017 Persistently active microbial molecules prolong innate immune tolerance in vivo, Lu, M., A.W. Varley, and R.S. Munford, 2013 The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo, Lu, M., and R.S. Munford, 2011 Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection, Lu, M., A.W. Varley, S. Ohta, J. Hardwick, and R.S. Munford, 2008 Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria, Lu, M., M. Zhang, A. Takashima, J. Weiss, M.A. Apicella, X.H. Li, D. Yuan, and R.S. Munford, 2005 Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells, Lu, M., M. Zhang, R.L. Kitchens, S. Fosmire, A. Takashima, and R.S. Munford, 2003

Areas of Focus

Regulatory mechanisms of anti-infective immunity
Pulmonary and intestinal mucosal immunity
Innate immune response and metabolic diseases
Macrophage metabolism and reprogramming

Publications

A highly conserved host lipase deacylates oxidized phospholipids and ameliorates acute lung injury in mice, Zou, B., M. Goodwin, D. Saleem, W. Jiang, J. Tang, Y. Chu, R.S. Munford, and M. Lu, 2021
A host lipase prevents lipopolysaccharide-induced foam cell formation, Feng, J., W. Jiang, X. Cheng, B. Zou, A. Varley, T. Liu, G. Qian, W. Zeng, J. Tang, Q. Zhao, Y. Chu, Y. Wei, X. Li, R. Munford, and M. Lu, 2021
Extracellular Acidity Reprograms Macrophage Metabolism and Innate Responsiveness, Jiang, W., J. Le, P.Y. Wang, X. Cheng, M. Smelkinson, W. Dong, C. Yang, Y. Chu, P.M. Hwang, R.S. Munford, and M. Lu, 2021
LPS inactivation by a host lipase allows lung epithelial cell sensitization for allergic asthma, Qian, G., W. Jiang, B. Zou, J. Feng, X. Cheng, J. Gu, T. Chu, C. Niu, R. He, Y. Chu, and M. Lu, 2018
Acyloxyacyl hydrolase promotes the resolution of lipopolysaccharide-induced acute lung injury, Zou, B., W. Jiang, H. Han, J. Li, W. Mao, Z. Tang, Q. Yang, G. Qian, J. Qian, W. Zeng, J. Gu, T. Chu, N. Zhu, W. Zhang, D. Yan, R. He, Y. Chu, and M. Lu, 2017
Persistently active microbial molecules prolong innate immune tolerance in vivo, Lu, M., A.W. Varley, and R.S. Munford, 2013
The transport and inactivation kinetics of bacterial lipopolysaccharide influence its immunological potency in vivo, Lu, M., and R.S. Munford, 2011
Host inactivation of bacterial lipopolysaccharide prevents prolonged tolerance following gram-negative bacterial infection, Lu, M., A.W. Varley, S. Ohta, J. Hardwick, and R.S. Munford, 2008
Lipopolysaccharide deacylation by an endogenous lipase controls innate antibody responses to Gram-negative bacteria, Lu, M., M. Zhang, A. Takashima, J. Weiss, M.A. Apicella, X.H. Li, D. Yuan, and R.S. Munford, 2005
Stimulus-dependent deacylation of bacterial lipopolysaccharide by dendritic cells, Lu, M., M. Zhang, R.L. Kitchens, S. Fosmire, A. Takashima, and R.S. Munford, 2003

Anti-Infective Immunity Regulation Mechanisms Pulmonary Immunity Intestinal Immunity Mucosal Immunity Innate Immune Response Metabolic Diseases Macrophage Metabolism Reprogramming

Cong Xin - Peking University

Yu Yu - Peking University

Ji Yanxiao - Wuhan University

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