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Qingtong Zhou
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
G Protein-Coupled Receptors
Structure
Function
Drug Screening
Design
Protein Targets
Neuroscience
Molecular Mechanisms
Pharmacology
Biochemistry
Areas of Focus
- Structure and Function of G Protein-Coupled Receptors
- Drug Screening and Design for Important Protein Targets
Work Experience
- 2015.07—2018.09 - ShanghaiTech University iHuman Institute - Postdoctoral Researcher
- 2018.10—2020.06 - ShanghaiTech University iHuman Institute - Research Assistant Professor
- 2020.07—Present - Fudan University School of Basic Medical Sciences - Junior Researcher
Academic Background & Achievements
- 2005.09—2009.06 Bachelor's Degree in Polymer Chemistry: University of Science and Technology of China
- 2009.09—2015.06 Ph.D. in Polymer Chemistry and Physics: University of Science and Technology of China
- 2012.09—2014.09 Joint Ph.D. Student in Chemistry and Biochemistry: Harvard University
- 2019.09—2019.12 Visiting Scholar: KU Leuven Cancer Research Center
Publications
- Searching the Sequence Space for Potent Aptamers Using SELEX in Silico, Zhou, Q., Xia, X., Luo, Z., Liang, H., and Shakhnovich, E., 2015
- Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space, Zhou, Q., Sun, X., Xia, X., Fan, Z., Luo, Z., Zhao, S., Shakhnovich, E., and Liang, H., 2017
- Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators, Song, G., Yang, D., Wang, Y., de Graaf, C., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., et al., 2017
- Common activation mechanism of class A GPCRs, Zhou, Q., Yang, D., Wu, M., Guo, Y., Guo, W., Zhong, L., Cai, X., Dai, A., Jang, W., Shakhnovich, E.I., et al., 2019
- Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands, Tan, L., Zhou, Q., Yan, W., Sun, J., Kozikowski, A.P., Zhao, S., Huang, X.P., and Cheng, J., 2020
- A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, Sun, W., Chen, L.N., Zhou, Q., Zhao, L.H., Yang, D., Zhang, H., Cong, Z., Shen, D.D., Zhao, F., Zhou, F., et al., 2020
- Structures of the human cholecystokinin receptors bound to agonists and antagonists, Zhang, X., He, C., Wang, M., Zhou, Q., Yang, D., Zhu, Y., Feng, W., Zhang, H., Dai, A., Chu, X., et al., 2021
- Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors, Zhao, F., Zhou, Q., Cong, Z., Hang, K., Zou, X., Zhang, C., Chen, Y., Dai, A., Liang, A., Ming, Q., et al., 2022
- Crystal structure of a constitutive active mutant of adenosine A2A receptor, Cui, M., Zhou, Q., Xu, Y., Weng, Y., Yao, D., Zhao, S., and Song, G., 2022
- Structural perspective of class B1 GPCR signaling, Cong, Z., Liang, Y.L., Zhou, Q., Darbalaei, S., Zhao, F., Feng, W., Zhao, L., Xu, H.E., Yang, D., and Wang, M.W., 2022
Awards
- 2018 - National Natural Science Foundation of China Youth Project: Principal Investigator
- 2016 - China Postdoctoral Science Foundation: Principal Investigator
