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Di Zhu
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
Bcl9
Β-Catenin
Pharmacology
Mechanisms
Tumor
Immunotherapy
Drug Development
Cancer
Targeting
Research
Areas of Focus
- Pharmacological Mechanisms Targeting BCL9/β-catenin
- Development of New Drugs for Tumor Immunotherapy
Work Experience
- 2011.01—2015.06 - Dana-Farber Cancer Institute, Harvard University - Postdoctoral Researcher
- 2015.07—2016.05 - Dana-Farber Cancer Institute, Harvard University - Lecturer (Junior Faculty)
- 2016.10—2021.07 - School of Pharmacy, Fudan University - Doctoral Supervisor
- 2017.01—Present - Minhang Hospital, Fudan University - Part-time Professor
- 2021.08—Present - Basic Medical Sciences, Fudan University - Doctoral Supervisor
Academic Background & Achievements
- 2001.09—2005.07 Bachelor's in Biochemistry and Molecular Biology: Shandong University
- 2005.09—2010.07 Ph.D. in Biochemistry and Molecular Biology: Graduate School of the Chinese Academy of Sciences
Publications
- Interferon-α potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment., Hu, B., Yu, M., Ma, X., Sun, J., Liu, C., Wang, C., Wu, S., Fu, P., Yang, Z., He, Y., Zhu, Y., Huang, C., Yang, X., Shi, Y., Qiu, S., Sun, H., Zhu, A., Zhou, J., Xu, Y., Zhu, D.*, Fan, J.*, 2022
- RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers., Xia, L., Tian, E., Yu, M., Liu, C., Shen, L., Huang, Y., Wu, Z., Tian, J., Yu, K., Wang, Y., Xie, D., Zhu, D.*, 2022
- BCL9 regulates CD226 and CD96 checkpoints in CD8+ T cells to improve PD-1 response in cancer., Feng, M., Wu, Z., Zhou, Y., Wei, Z., Tian, E., Mei, S., Zhu, Y., Liu, C., He, F., Li, H., Xie, C., Jin, J., Dong, J., Yang, D., Yu, K., Qian, J., Lambrechts, D.*, Wang, M.*, Zhu, D.*, 2021
- BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer., Wang, X., Feng, M., Xiao, T., Guo, B., Liu, D., Liu, C., Pei, J., Liu, Q., Xiao, Y., Rosin-Arbesfeld, R., Shi, Y., Zhou, Y., Yang, M., Feng, Y., Jiang, Y., Shao, Z., Yu, K.*, Zhu, D.*, 2021
- Discovery of a novel, potent, and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumor efficacy., Liu, C., Zhou, F., Yan, Z., Shen, L., Zhang, X., He, F., Wang, H., Lu, X., Yu, K., Zhao, Y.*, Zhu, D.*, 2021
- RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer., Tian, E., Yu, M., Feng, M., Wang, Y., Xie, Q.*, Zhu, D.*, 2021
- T-cell-based immunotherapy in colorectal cancer., Feng, M., Zhao, Z., Yang, M., Ji, J., Zhu, D.*, 2021
- Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells., Feng, M., Jin, J., Xia, L., Xiao, T., Mei, S., Wang, X., Huang, X., Chen, J., Liu, M., Chen, C., Raf, S., Zhu, A., Feng, Y.*, Zhu, D.*, 2019
- The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells., Zhu, D., Wang, Z., Zhao, J., Calimeri, T., Meng, J., Hideshima, T., Fulciniti, M., Kang, Y., Ficarro, S., Tai, Y., Hunter, Z., McMilin, D., Tong, H., Mitsiades, C., Wu, C., Treon, S., Dorfman, D., Pinkus, G., Munshi, N., Tassone, P., Marto, J., Anderson, K., Carrasco, R.*, 2015
- Targeted Disruption of the BCL9/β-Catenin Complex Inhibits Oncogenic Wnt Signaling., Takada, K.#, Zhu, D.#, Bird, GH. #, Sukhdeol, K., Zhao, J., Mani, M., Lemieux, M., Carrasco, D., Ryan, J., Horst, D., Fulciniti, M., Mushi, NC., Xu, W., Kung, AL., Shivdasani, R., Walensky, L.*, Carrasco, R.*, 2012
Awards
- 2024: Fudan University Excellent Doctoral Dissertation Supervisor
- 2024: Bronze Award at the 35th Shanghai Excellent Invention Selection Competition
- 2023: Second Prize of the Chinese Anti-Cancer Association Science and Technology Award
- 2022: Shanghai Bioengineering Society 'Dongfulong' Bioengineering Excellent Young Scientist Award
- 2019: Zeng Ai·Changmu Academic Award, Zeng Ai China Foundation
- 2010: FEBS Youth Travel Fellowship, Federation of European Biochemical Societies
