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Si Zhang
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
Platelet Activation
Antithrombotic Drugs
Clinical Translation
Tumor Markers
Therapeutic Targets
Genetic Diseases
Pathogenesis
Screening
Biochemistry
Molecular Biology
Areas of Focus
- Mechanisms of Platelet Activation and Clinical Translation of Antithrombotic Drugs
- Screening of Early Tumor Markers and Clinical Translation of Therapeutic Targets
- Pathogenesis and Clinical Translation of Therapeutic Targets for Genetic Diseases
Work Experience
- 2000.07—2008.10 - Fudan University - Teaching Assistant
- 2008.11—2014.10 - Fudan University - Lecturer
- 2014.11—2020.10 - Fudan University - Associate Professor, Visiting Scholar at Texas Medical Center
- 2020.11—Present - Fudan University - Professor
Academic Background & Achievements
- 1995.09—2000.07 Bachelor's Degree in Clinical Medicine: Anhui Medical University
- 2008.09—2012.07 PhD in Biochemistry and Molecular Biology: Fudan University
Publications
- S1P Defects Cause a New Entity of Cataract, Alopecia, Oral Mucosal Disorder, and Psoriasis-like Syndrome, Fuing Chen, Cheng Ni, Xiaoxiao Wang, Ruhong Cheng, Chaolan Pan, Yumeng Wang, Jianying Liang, Jia Zhang, Jinke Cheng, Y Eugene Chin, Yi Zhou, Zhen Wang, Yiran Guo, She Chen, Stephanie Htun, Erin F. Mathes, Alejandra G. de Alba Campomanes, Anne M. Slavotinek, Si Zhang, Ming Li, Zhirong Yao, 2022
- A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients, Wang, Biyun; Zhao, Yannan; Li, Yi; Xu, Yingying; Chen, Yun; Jiang, Qiuyu; Yao, Dingjin; Zhang, Li; Hu, Xichun; Fu, Chaowei; Zhang, Si; Chen, She, 2022
- Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study, Chen, Yufei; Fu, Wanrong; Zheng, Yunbo; Yang, Jing; Liu, Yangyang; Qi, Zhiyong; Wu, Meiling; Fan, Zhichao; Yin, Kanhua; Chen, Yunfeng; Gao, Wen; Ding, Zhongren; Dong, Jianzeng; Li, Qi; Zhang, Si; Hu, Liang, 2022
- Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism, Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue, Si Zhang, 2021
- Gut microbiota-mediated immunomodulation in tumor, Xinyi Liu, Yanjie Chen, Si Zhang, Ling Dong, 2021
- SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19, Si Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang, Liang Hu, 2020
- Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma, Pingping Dong, Xiaoxiao Wang, Longzi Liu, Wenqing Tang, Lijie Ma, Wenjiao Zeng, Shaoyang Sun, Li Zhang, Ningping Zhang, Xizhong Shen, Harry L.A. Janssen, Ling Dong, Si Zhang, She Chen, 2020
- Nucleotide-Binding Oligomerization Domain 2 Receptor Is Expressed in Platelets and Enhances Platelet Activation and Thrombosis, Si Zhang, Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei Chen, Guanjun Cheng, Jozef Mruk, SP Kunapuli, Zhongren Ding, 2015
- Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1, Liu, Xijun; Xue, Ruyi; Yang, Caiting; Gu, Jianxin; Chen, She; Zhang, Si, 2018
- Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition, Cai, Yu; Huang, Guanqun; Ma, Lijie; Dong, Ling; Chen, She; Shen, Xizhong; Zhang, Shuncai; Xue, Ruyi; Sun, Deqiang; Zhang, Si, 2018
Awards
- 2014: 'Reach the world' award, International Society on Thrombosis and Haemostasis (ISTH)
- 2002: Shanghai Medical Science Second Prize, Shanghai Medical Association
