Professor | Si Zhang | Asia Growth Partners

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Name	Si Zhang
Contact Information	zhangsi@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Si Zhang

Contact Information

zhangsi@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1995.09—2000.07 Bachelor's Degree in Clinical Medicine: Anhui Medical University 2008.09—2012.07 PhD in Biochemistry and Molecular Biology: Fudan University
Work Experience	2000.07—2008.10 - Fudan University - Teaching Assistant 2008.11—2014.10 - Fudan University - Lecturer 2014.11—2020.10 - Fudan University - Associate Professor, Visiting Scholar at Texas Medical Center 2020.11—Present - Fudan University - Professor
Awards	2014: 'Reach the world' award, International Society on Thrombosis and Haemostasis (ISTH) 2002: Shanghai Medical Science Second Prize, Shanghai Medical Association

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1995.09—2000.07 Bachelor's Degree in Clinical Medicine: Anhui Medical University
2008.09—2012.07 PhD in Biochemistry and Molecular Biology: Fudan University

Work Experience

2000.07—2008.10 - Fudan University - Teaching Assistant
2008.11—2014.10 - Fudan University - Lecturer
2014.11—2020.10 - Fudan University - Associate Professor, Visiting Scholar at Texas Medical Center
2020.11—Present - Fudan University - Professor

Awards

2014: 'Reach the world' award, International Society on Thrombosis and Haemostasis (ISTH)
2002: Shanghai Medical Science Second Prize, Shanghai Medical Association

Areas of Focus	Mechanisms of Platelet Activation and Clinical Translation of Antithrombotic Drugs Screening of Early Tumor Markers and Clinical Translation of Therapeutic Targets Pathogenesis and Clinical Translation of Therapeutic Targets for Genetic Diseases
Publications	S1P Defects Cause a New Entity of Cataract, Alopecia, Oral Mucosal Disorder, and Psoriasis-like Syndrome, Fuing Chen, Cheng Ni, Xiaoxiao Wang, Ruhong Cheng, Chaolan Pan, Yumeng Wang, Jianying Liang, Jia Zhang, Jinke Cheng, Y Eugene Chin, Yi Zhou, Zhen Wang, Yiran Guo, She Chen, Stephanie Htun, Erin F. Mathes, Alejandra G. de Alba Campomanes, Anne M. Slavotinek, Si Zhang, Ming Li, Zhirong Yao, 2022 A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients, Wang, Biyun; Zhao, Yannan; Li, Yi; Xu, Yingying; Chen, Yun; Jiang, Qiuyu; Yao, Dingjin; Zhang, Li; Hu, Xichun; Fu, Chaowei; Zhang, Si; Chen, She, 2022 Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study, Chen, Yufei; Fu, Wanrong; Zheng, Yunbo; Yang, Jing; Liu, Yangyang; Qi, Zhiyong; Wu, Meiling; Fan, Zhichao; Yin, Kanhua; Chen, Yunfeng; Gao, Wen; Ding, Zhongren; Dong, Jianzeng; Li, Qi; Zhang, Si; Hu, Liang, 2022 Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism, Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue, Si Zhang, 2021 Gut microbiota-mediated immunomodulation in tumor, Xinyi Liu, Yanjie Chen, Si Zhang, Ling Dong, 2021 SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19, Si Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang, Liang Hu, 2020 Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma, Pingping Dong, Xiaoxiao Wang, Longzi Liu, Wenqing Tang, Lijie Ma, Wenjiao Zeng, Shaoyang Sun, Li Zhang, Ningping Zhang, Xizhong Shen, Harry L.A. Janssen, Ling Dong, Si Zhang, She Chen, 2020 Nucleotide-Binding Oligomerization Domain 2 Receptor Is Expressed in Platelets and Enhances Platelet Activation and Thrombosis, Si Zhang, Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei Chen, Guanjun Cheng, Jozef Mruk, SP Kunapuli, Zhongren Ding, 2015 Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1, Liu, Xijun; Xue, Ruyi; Yang, Caiting; Gu, Jianxin; Chen, She; Zhang, Si, 2018 Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition, Cai, Yu; Huang, Guanqun; Ma, Lijie; Dong, Ling; Chen, She; Shen, Xizhong; Zhang, Shuncai; Xue, Ruyi; Sun, Deqiang; Zhang, Si, 2018

Areas of Focus

Mechanisms of Platelet Activation and Clinical Translation of Antithrombotic Drugs
Screening of Early Tumor Markers and Clinical Translation of Therapeutic Targets
Pathogenesis and Clinical Translation of Therapeutic Targets for Genetic Diseases

Publications

S1P Defects Cause a New Entity of Cataract, Alopecia, Oral Mucosal Disorder, and Psoriasis-like Syndrome, Fuing Chen, Cheng Ni, Xiaoxiao Wang, Ruhong Cheng, Chaolan Pan, Yumeng Wang, Jianying Liang, Jia Zhang, Jinke Cheng, Y Eugene Chin, Yi Zhou, Zhen Wang, Yiran Guo, She Chen, Stephanie Htun, Erin F. Mathes, Alejandra G. de Alba Campomanes, Anne M. Slavotinek, Si Zhang, Ming Li, Zhirong Yao, 2022
A plasma SNORD33 signature predicts platinum benefit in metastatic triple-negative breast cancer patients, Wang, Biyun; Zhao, Yannan; Li, Yi; Xu, Yingying; Chen, Yun; Jiang, Qiuyu; Yao, Dingjin; Zhang, Li; Hu, Xichun; Fu, Chaowei; Zhang, Si; Chen, She, 2022
Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study, Chen, Yufei; Fu, Wanrong; Zheng, Yunbo; Yang, Jing; Liu, Yangyang; Qi, Zhiyong; Wu, Meiling; Fan, Zhichao; Yin, Kanhua; Chen, Yunfeng; Gao, Wen; Ding, Zhongren; Dong, Jianzeng; Li, Qi; Zhang, Si; Hu, Liang, 2022
Hepatic NOD2 promotes hepatocarcinogenesis via a RIP2-mediated proinflammatory response and a novel nuclear autophagy-mediated DNA damage mechanism, Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue, Si Zhang, 2021
Gut microbiota-mediated immunomodulation in tumor, Xinyi Liu, Yanjie Chen, Si Zhang, Ling Dong, 2021
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19, Si Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang, Liang Hu, 2020
Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma, Pingping Dong, Xiaoxiao Wang, Longzi Liu, Wenqing Tang, Lijie Ma, Wenjiao Zeng, Shaoyang Sun, Li Zhang, Ningping Zhang, Xizhong Shen, Harry L.A. Janssen, Ling Dong, Si Zhang, She Chen, 2020
Nucleotide-Binding Oligomerization Domain 2 Receptor Is Expressed in Platelets and Enhances Platelet Activation and Thrombosis, Si Zhang, Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei Chen, Guanjun Cheng, Jozef Mruk, SP Kunapuli, Zhongren Ding, 2015
Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1, Liu, Xijun; Xue, Ruyi; Yang, Caiting; Gu, Jianxin; Chen, She; Zhang, Si, 2018
Smurf2, an E3 ubiquitin ligase, interacts with PDE4B and attenuates liver fibrosis through miR-132 mediated CTGF inhibition, Cai, Yu; Huang, Guanqun; Ma, Lijie; Dong, Ling; Chen, She; Shen, Xizhong; Zhang, Shuncai; Xue, Ruyi; Sun, Deqiang; Zhang, Si, 2018

Platelet Activation Antithrombotic Drugs Clinical Translation Tumor Markers Therapeutic Targets Genetic Diseases Pathogenesis Screening Biochemistry Molecular Biology

Guoheng Xu - Peking University

Tanjun Tong - Peking University

Xiaowei Zhang - Peking University

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