Professor | 张思 | 数字化转型顾问

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Name	张思
Contact Information	zhangsi@fudan.edu.cn
Language ability	中文, 英文
Province	上海

Upload Avatar (500 x 500)

Name

张思

Contact Information

zhangsi@fudan.edu.cn

Language ability

中文, 英文

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	1995.09—2000.07 临床医学专业本科生: 安徽医科大学 2008.09—2012.07 生物化学与分子生物学专业博士研究生: 复旦大学
Work Experience	2000.07—2008.10 - 复旦大学 - 助教 2008.11—2014.10 - 复旦大学 - 讲师 2014.11—2020.10 - 复旦大学 - 副教授，期间在德克萨斯医学中心访学 2020.11—至今 - 复旦大学 - 教授
Awards	2014: “Reach the world”奖，国际血栓与止血协会（ISTH） 2002: 上海医学科技二等奖，上海市医学会

University/Lab Affiliation and Title

复旦大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

1995.09—2000.07 临床医学专业本科生: 安徽医科大学
2008.09—2012.07 生物化学与分子生物学专业博士研究生: 复旦大学

Work Experience

2000.07—2008.10 - 复旦大学 - 助教
2008.11—2014.10 - 复旦大学 - 讲师
2014.11—2020.10 - 复旦大学 - 副教授，期间在德克萨斯医学中心访学
2020.11—至今 - 复旦大学 - 教授

Awards

2014: “Reach the world”奖，国际血栓与止血协会（ISTH）
2002: 上海医学科技二等奖，上海市医学会

Areas of Focus	血小板激活机制和抗血栓药物临床转化肿瘤早期标志物筛选和治疗靶点临床转化遗传性疾病发病和治疗靶点临床转化
Publications	S1P缺陷导致白内障、脱发、口腔粘膜疾病和银屑病样综合征的新实体, Fuing Chen, Cheng Ni, Xiaoxiao Wang, Ruhong Cheng, Chaolan Pan, Yumeng Wang, Jianying Liang, Jia Zhang, Jinke Cheng, Y Eugene Chin, Yi Zhou, Zhen Wang, Yiran Guo, She Chen, Stephanie Htun, Erin F. Mathes, Alejandra G. de Alba Campomanes, Anne M. Slavotinek, Si Zhang, Ming Li, Zhirong Yao, 2022 血浆SNORD33特征预测转移性三阴性乳腺癌患者的铂类药物获益, Wang, Biyun; Zhao, Yannan; Li, Yi; Xu, Yingying; Chen, Yun; Jiang, Qiuyu; Yao, Dingjin; Zhang, Li; Hu, Xichun; Fu, Chaowei; Zhang, Si; Chen, She, 2022 Galectin 3通过Dectin-1激活增强血小板聚集和血栓形成：一项转化研究, Chen, Yufei; Fu, Wanrong; Zheng, Yunbo; Yang, Jing; Liu, Yangyang; Qi, Zhiyong; Wu, Meiling; Fan, Zhichao; Yin, Kanhua; Chen, Yunfeng; Gao, Wen; Ding, Zhongren; Dong, Jianzeng; Li, Qi; Zhang, Si; Hu, Liang, 2022 肝脏NOD2通过RIP2介导的促炎反应和一种新的核自噬介导的DNA损伤机制促进肝癌发生, Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue, Si Zhang, 2021 肠道微生物群介导的肿瘤免疫调节, Xinyi Liu, Yanjie Chen, Si Zhang, Ling Dong, 2021 SARS-CoV-2结合血小板ACE2以增强COVID-19中的血栓形成, Si Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang, Liang Hu, 2020 VEPH1减弱通过削弱TSC1/TSC2关联激活mTORC1信号通路在肝细胞癌中的作用, Pingping Dong, Xiaoxiao Wang, Longzi Liu, Wenqing Tang, Lijie Ma, Wenjiao Zeng, Shaoyang Sun, Li Zhang, Ningping Zhang, Xizhong Shen, Harry L.A. Janssen, Ling Dong, Si Zhang, She Chen, 2020 核苷酸结合寡聚化结构域2受体在血小板中表达并增强血小板激活和血栓形成, Si Zhang, Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei Chen, Guanjun Cheng, Jozef Mruk, SP Kunapuli, Zhongren Ding, 2015 胆汁淤积引起的胆汁酸通过法尼醇X受体介导的抑制雌激素硫转移酶SULT1E1升高雌激素水平, Liu, Xijun; Xue, Ruyi; Yang, Caiting; Gu, Jianxin; Chen, She; Zhang, Si, 2018 Smurf2，一种E3泛素连接酶，通过miR-132介导的CTGF抑制与PDE4B相互作用并减轻肝纤维化, Cai, Yu; Huang, Guanqun; Ma, Lijie; Dong, Ling; Chen, She; Shen, Xizhong; Zhang, Shuncai; Xue, Ruyi; Sun, Deqiang; Zhang, Si, 2018

Areas of Focus

血小板激活机制和抗血栓药物临床转化
肿瘤早期标志物筛选和治疗靶点临床转化
遗传性疾病发病和治疗靶点临床转化

Publications

S1P缺陷导致白内障、脱发、口腔粘膜疾病和银屑病样综合征的新实体, Fuing Chen, Cheng Ni, Xiaoxiao Wang, Ruhong Cheng, Chaolan Pan, Yumeng Wang, Jianying Liang, Jia Zhang, Jinke Cheng, Y Eugene Chin, Yi Zhou, Zhen Wang, Yiran Guo, She Chen, Stephanie Htun, Erin F. Mathes, Alejandra G. de Alba Campomanes, Anne M. Slavotinek, Si Zhang, Ming Li, Zhirong Yao, 2022
血浆SNORD33特征预测转移性三阴性乳腺癌患者的铂类药物获益, Wang, Biyun; Zhao, Yannan; Li, Yi; Xu, Yingying; Chen, Yun; Jiang, Qiuyu; Yao, Dingjin; Zhang, Li; Hu, Xichun; Fu, Chaowei; Zhang, Si; Chen, She, 2022
Galectin 3通过Dectin-1激活增强血小板聚集和血栓形成：一项转化研究, Chen, Yufei; Fu, Wanrong; Zheng, Yunbo; Yang, Jing; Liu, Yangyang; Qi, Zhiyong; Wu, Meiling; Fan, Zhichao; Yin, Kanhua; Chen, Yunfeng; Gao, Wen; Ding, Zhongren; Dong, Jianzeng; Li, Qi; Zhang, Si; Hu, Liang, 2022
肝脏NOD2通过RIP2介导的促炎反应和一种新的核自噬介导的DNA损伤机制促进肝癌发生, Yi Zhou, Liang Hu, Wenqing Tang, Dongping Li, Lijie Ma, Hongchun Liu, Shuncai Zhang, Xiaojie Zhang, Ling Dong, Xizhong Shen, She Chen, Ruyi Xue, Si Zhang, 2021
肠道微生物群介导的肿瘤免疫调节, Xinyi Liu, Yanjie Chen, Si Zhang, Ling Dong, 2021
SARS-CoV-2结合血小板ACE2以增强COVID-19中的血栓形成, Si Zhang, Yangyang Liu, Xiaofang Wang, Li Yang, Haishan Li, Yuyan Wang, Mengduan Liu, Xiaoyan Zhao, Youhua Xie, Yan Yang, Shenghui Zhang, Zhichao Fan, Jianzeng Dong, Zhenghong Yuan, Zhongren Ding, Yi Zhang, Liang Hu, 2020
VEPH1减弱通过削弱TSC1/TSC2关联激活mTORC1信号通路在肝细胞癌中的作用, Pingping Dong, Xiaoxiao Wang, Longzi Liu, Wenqing Tang, Lijie Ma, Wenjiao Zeng, Shaoyang Sun, Li Zhang, Ningping Zhang, Xizhong Shen, Harry L.A. Janssen, Ling Dong, Si Zhang, She Chen, 2020
核苷酸结合寡聚化结构域2受体在血小板中表达并增强血小板激活和血栓形成, Si Zhang, Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei Chen, Guanjun Cheng, Jozef Mruk, SP Kunapuli, Zhongren Ding, 2015
胆汁淤积引起的胆汁酸通过法尼醇X受体介导的抑制雌激素硫转移酶SULT1E1升高雌激素水平, Liu, Xijun; Xue, Ruyi; Yang, Caiting; Gu, Jianxin; Chen, She; Zhang, Si, 2018
Smurf2，一种E3泛素连接酶，通过miR-132介导的CTGF抑制与PDE4B相互作用并减轻肝纤维化, Cai, Yu; Huang, Guanqun; Ma, Lijie; Dong, Ling; Chen, She; Shen, Xizhong; Zhang, Shuncai; Xue, Ruyi; Sun, Deqiang; Zhang, Si, 2018

血小板激活抗血栓药物临床转化肿瘤标志物治疗靶点遗传性疾病发病机制筛选生物化学分子生物学

卢颖 - 复旦大学

徐国恒 - 北京大学

童坦君 - 北京大学

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