Professor | Pingzhao Zhang | Asia Growth Partners

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Name	Pingzhao Zhang
Contact Information	pzzhang@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Pingzhao Zhang

Contact Information

pzzhang@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Areas of Focus	Regulation mechanism of ubiquitination modification of important proteins in the process of tumorigenesis and development
Publications	Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation., Zhang P#, Wang D#, Zhao Y#, Ren S#, Gao K#, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H., 2017 CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation., Zhang P#, Gao K#, Zhang L#, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W, Wang C., 2021 RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction., Gao K, Wang C, Jin X, Xiao J, Zhang E, Yang X, Wang D, Huang H, Yu L, Zhang P., 2016 SPOP mutation induces DNA methylation via stabilizing GLP/G9a., Zhang J#, Gao K#, Xie H#, Wang D#, Zhang P#, Wei T, Yan Y, Pan Y, Ye W, Chen H, Shi Q, Li Y, Zhao SM, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, He HH, Wang L, Wang C, Huang H., 2021 PI3K Activation Is Enhanced by FOXM1D Binding to p110 and p85 Subunits., Wang Q#, Zhang P#, Zhang W, Zhang X, Chen J, Ding P, Li L, Lv X, Li L, Hu W., 2020 iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation., Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao SM, Li Y, Zhang P, Wang C., 2018 Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover., Zhang P#, Gao K#, Jin X, Ma J, Peng J, Wumaier R, Tang Y, Zhang Y, An J, Yan Q, Dong Y, Huang H, Yu L, Wang C., 2015 Destruction of DDIT3/CHOP Protein by Wild-Type SPOP but Not Prostate Cancer-Associated Mutants., Zhang P#, Gao K#, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L, Wang C., 2014 Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells., Gao K, Jin X, Tang Y, Ma J, Peng J, Yu L, Zhang P, Wang C., 2015 The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation., Zhang P#, Wang C#, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L., 2010

Areas of Focus

Regulation mechanism of ubiquitination modification of important proteins in the process of tumorigenesis and development

Publications

Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation., Zhang P#, Wang D#, Zhao Y#, Ren S#, Gao K#, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H., 2017
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation., Zhang P#*, Gao K#*, Zhang L#, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W*, Wang C*., 2021
RNF12 promotes p53-dependent cell growth suppression and apoptosis by targeting MDM2 for destruction., Gao K, Wang C, Jin X, Xiao J, Zhang E, Yang X, Wang D, Huang H, Yu L*, Zhang P*., 2016
SPOP mutation induces DNA methylation via stabilizing GLP/G9a., Zhang J#, Gao K#, Xie H#, Wang D#, Zhang P#, Wei T, Yan Y, Pan Y, Ye W, Chen H, Shi Q, Li Y, Zhao SM, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, He HH, Wang L, Wang C, Huang H., 2021
PI3K Activation Is Enhanced by FOXM1D Binding to p110 and p85 Subunits., Wang Q#, Zhang P#, Zhang W, Zhang X, Chen J, Ding P, Li L, Lv X, Li L, Hu W., 2020
iASPP-PP1 complex is required for cytokinetic abscission by controlling CEP55 dephosphorylation., Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao SM, Li Y, Zhang P*, Wang C*., 2018
Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover., Zhang P#, Gao K#, Jin X, Ma J, Peng J, Wumaier R, Tang Y, Zhang Y, An J, Yan Q, Dong Y, Huang H, Yu L, Wang C., 2015
Destruction of DDIT3/CHOP Protein by Wild-Type SPOP but Not Prostate Cancer-Associated Mutants., Zhang P#, Gao K#, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L, Wang C., 2014
Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells., Gao K, Jin X, Tang Y, Ma J, Peng J, Yu L, Zhang P*, Wang C*., 2015
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation., Zhang P#, Wang C#, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L., 2010

Ubiquitination Protein Tumorigenesis Development Regulation Modification Mechanism Cancer Proteins Research

Jun Xu - Peking University

Xiaowei Zhang - Peking University

Ying Zhao - Peking University

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