Professor | 章平肇 | 数字化转型顾问

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Name	章平肇
Contact Information	pzzhang@fudan.edu.cn
Language ability	中文, 英语
Province	上海

Upload Avatar (500 x 500)

Name

章平肇

Contact Information

pzzhang@fudan.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Basic Medical Sciences

University/Lab Affiliation and Title

复旦大学

Faculty

Basic Medical Sciences

Areas of Focus	肿瘤发生发展过程中重要蛋白质的泛素化修饰调控机制研究
Publications	SPOP突变前列腺癌中BET蛋白稳定性和AKT-mTORC1激活介导的内在BET抑制剂耐药性。, Zhang P#, Wang D#, Zhao Y#, Ren S#, Gao K#, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H., 2017 CRL2-KLHDC3 E3泛素连接酶复合物通过促进p14(ARF)降解抑制铁死亡。, Zhang P#, Gao K#, Zhang L#, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W, Wang C., 2021 RNF12通过靶向MDM2破坏促进p53依赖的细胞生长抑制和凋亡。, Gao K, Wang C, Jin X, Xiao J, Zhang E, Yang X, Wang D, Huang H, Yu L, Zhang P., 2016 SPOP突变通过稳定GLP/G9a诱导DNA甲基化。, Zhang J#, Gao K#, Xie H#, Wang D#, Zhang P#, Wei T, Yan Y, Pan Y, Ye W, Chen H, Shi Q, Li Y, Zhao SM, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, He HH, Wang L, Wang C, Huang H., 2021 FOXM1D与p110和p85亚基结合增强PI3K激活。, Wang Q#, Zhang P#, Zhang W, Zhang X, Chen J, Ding P, Li L, Lv X, Li L, Hu W., 2020 iASPP-PP1复合物通过控制CEP55去磷酸化在细胞分裂末期的细胞质分裂中起作用。, Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao SM, Li Y, Zhang P, Wang C., 2018 子宫内膜癌相关的SPOP突变体在调节雌激素受体-α蛋白周转方面存在缺陷。, Zhang P#, Gao K#, Jin X, Ma J, Peng J, Wumaier R, Tang Y, Zhang Y, An J, Yan Q, Dong Y, Huang H, Yu L, Wang C., 2015 野生型SPOP而非前列腺癌相关突变体破坏DDIT3/CHOP蛋白。, Zhang P#, Gao K#, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L, Wang C., 2014 肿瘤抑制因子SPOP在乳腺癌细胞中介导孕激素受体（PRs）的蛋白酶体降解。, Gao K, Jin X, Tang Y, Ma J, Peng J, Yu L, Zhang P, Wang C., 2015 泛素连接酶Itch通过靶向硫氧还蛋白相互作用蛋白进行泛素依赖性降解来调节凋亡。, Zhang P#, Wang C#, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L., 2010

Areas of Focus

肿瘤发生发展过程中重要蛋白质的泛素化修饰调控机制研究

Publications

SPOP突变前列腺癌中BET蛋白稳定性和AKT-mTORC1激活介导的内在BET抑制剂耐药性。, Zhang P#, Wang D#, Zhao Y#, Ren S#, Gao K#, Ye Z, Wang S, Pan CW, Zhu Y, Yan Y, Yang Y, Wu D, He Y, Zhang J, Lu D, Liu X, Yu L, Zhao S, Li Y, Lin D, Wang Y, Wang L, Chen Y, Sun Y, Wang C, Huang H., 2017
CRL2-KLHDC3 E3泛素连接酶复合物通过促进p14(ARF)降解抑制铁死亡。, Zhang P#*, Gao K#*, Zhang L#, Sun H, Zhao X, Liu Y, Lv Z, Shi Q, Chen Y, Jiao D, Li Y, Gu W*, Wang C*., 2021
RNF12通过靶向MDM2破坏促进p53依赖的细胞生长抑制和凋亡。, Gao K, Wang C, Jin X, Xiao J, Zhang E, Yang X, Wang D, Huang H, Yu L*, Zhang P*., 2016
SPOP突变通过稳定GLP/G9a诱导DNA甲基化。, Zhang J#, Gao K#, Xie H#, Wang D#, Zhang P#, Wei T, Yan Y, Pan Y, Ye W, Chen H, Shi Q, Li Y, Zhao SM, Hou X, Weroha SJ, Wang Y, Zhang J, Karnes RJ, He HH, Wang L, Wang C, Huang H., 2021
FOXM1D与p110和p85亚基结合增强PI3K激活。, Wang Q#, Zhang P#, Zhang W, Zhang X, Chen J, Ding P, Li L, Lv X, Li L, Hu W., 2020
iASPP-PP1复合物通过控制CEP55去磷酸化在细胞分裂末期的细胞质分裂中起作用。, Gao K, Zhang Y, Shi Q, Zhang J, Zhang L, Sun H, Jiao D, Zhao X, Tao H, Wei Y, Wang Y, Saiyin H, Zhao SM, Li Y, Zhang P*, Wang C*., 2018
子宫内膜癌相关的SPOP突变体在调节雌激素受体-α蛋白周转方面存在缺陷。, Zhang P#, Gao K#, Jin X, Ma J, Peng J, Wumaier R, Tang Y, Zhang Y, An J, Yan Q, Dong Y, Huang H, Yu L, Wang C., 2015
野生型SPOP而非前列腺癌相关突变体破坏DDIT3/CHOP蛋白。, Zhang P#, Gao K#, Tang Y, Jin X, An J, Yu H, Wang H, Zhang Y, Wang D, Huang H, Yu L, Wang C., 2014
肿瘤抑制因子SPOP在乳腺癌细胞中介导孕激素受体（PRs）的蛋白酶体降解。, Gao K, Jin X, Tang Y, Ma J, Peng J, Yu L, Zhang P*, Wang C*., 2015
泛素连接酶Itch通过靶向硫氧还蛋白相互作用蛋白进行泛素依赖性降解来调节凋亡。, Zhang P#, Wang C#, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L., 2010

泛素化蛋白质肿瘤发生发展调控修饰机制癌症研究

王宪 - 北京大学

徐军 - 北京大学

张晓伟 - 北京大学

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