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Jianzhong Chen
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Medicinal Chemistry
Drug Design
Lead Compound
Optimization
Structure-Activity Relationship
Pharmacology
Synthesis
Evaluation
Cannabinoid Receptor
Agonist
Areas of Focus
- Medicinal Chemistry
- Drug Design
- Lead Compound Optimization
- Structure-Activity Relationship
Work Experience
- 1996-1998 - Assistant Researcher: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1998-2005 - Researcher: University of Connecticut School of Pharmacy
- 2005-2008 - Postdoctoral Researcher: University of Houston School of Pharmacy
- 2008-2008 - Postdoctoral Researcher: University of Pittsburgh School of Pharmacy
- 2008-Present - Professor, Doctoral Supervisor: Zhejiang University School of Pharmacy
Academic Background & Achievements
- 1990 - Bachelor of Science: Hangzhou University (now Zhejiang University)
- 1993 - Master of Science in Organic Chemistry: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 1996 - Ph.D. in Organic Chemistry: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2005 - Ph.D. in Pharmacy: University of Connecticut
- 1997 - Second Prize of Natural Science Award, Chinese Academy of Sciences
Publications
- Development of Quinazoline/Pyrimidine-2,4(1H,3H)-diones as Agonists of Cannabinoid Receptor Type 2, H.-Y. Qian, Z.-L. Wang, Y.-L. Pan, L.-L. Chen, X. Xie, J.-Z. Chen, 2017
- Developing pyridazine-3-carboxamides to be CB2 agonists: The design, synthesis, structure-activity relationships and docking studies, H.-Y. Qian, Z.-L. Wang, X.-Y. Xie, Y.-L. Pan, G.-J. Li, X. Xie, J.-Z. Chen, 2017
- Understanding the relative affinity and specificity of the substrate binding site of protein kinase B for substrate-mimetic inhibitors, H.-Y. Qian, S.-F. Chen, Y.-L. Pan, J.-Z. Chen, 2017
- Molecular Modeling Studies of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors through Receptor-Based 3D-QSAR and Molecular Dynamics Simulations, H. Qian, J. Chen, Y. Pan, J.-Z Chen, 2016
- Molecular modeling studies to characterize N-phenylpyrimidin-2-amine selectivity for CDK2 and CDK4 through 3D-QSAR and molecular dynamics simulations, T. A. Chohan, J.-J. Chen, H.-Y. Qian, Y.-L. Pan, J.-Z. Chen, 2016
- Molecular simulation studies on the binding selectivity of 2-anilino-4-(thiazol-5-yl)- pyrimidines in complexes with CDK2 and CDK7, T. A. Chohan, H.-Y. Qian, Y.-L. Pan, J.-Z. Chen, 2016
- Development of quinoline-2,4(1H,3H)-diones as potent and selective ligands of the cannabinoid type 2 receptor, S. Han, F.-F. Zhang, H.-Y. Qian, L.-L. Chen, J.-B. Pu, X. Xie, J.-Z. Chen, 2015
- Design, Syntheses, Structure-Activity Relationships and Docking Studies of Coumarin Derivatives as Novel Selective Ligands for the CB2 Receptor, S. Han, F.-F. Zhang, H.-Y., L.-L. Chen, X. Xie, J.-Z. Chen, 2015
- Cyclin-dependent kinase-2 as a target for cancer therapy: Progress in the development of CDK2 inhibitors as anti-cancer agents, T. A. Chohan, H. Qian, Y. Pan, J.-Z. Chen, 2015
- MD and QM/MM Studies on Long-Chain L-α-Hydroxy Acid Oxidase: Substrate Binding Features and Oxidation Mechanism, Y. Cao, S. Han, L. Yu, H. Qian, J.-Z. Chen, 2014
- Latest Progress in the Identification of Novel Synthetic Ligands for the Cannabinoid CB2 Receptor, S. Han, J.-J. Chen, J.-Z. Chen, 2014
- Design, synthesis, biological evaluation, and comparative docking study of 1,2,4-triazolones as CB1 receptor selective antagonists, S. Han, F.-F. Zhang, X. Xie, J.-Z. Chen, 2014
- Computational Studies of the Regioselectivities of COMT-Catalyzed Meta-/Para-O Methylations of Luteolin and Quercetin, Y. Cao, Z.-J. Chen, H.-D. Jiang, J.-Z. Chen, 2014
- Hepatic Glucuronidation of Isoneochamaejasmin A from the Traditional Chinese Medicine Stellera Chamaejasme L. Root, L. Yu, J. Pu, M. Zuo, X. Zhang, Y. Cao, S. Chen, Y. Lou, Q. Zhou, H. Hu, H. Jiang, J.-Z. Chen, S. Zeng, 2014
- Insight into the structural mechanism for PKB _ allosteric inhibition by molecular dynamics simulations and free energy calculations, S.-F. Chen, Y. Cao, S. Han, J.-Z. Chen, 2014
- Binding selectivity studies of PKBα using molecular dynamics simulation and free energy calculations, S.-F. Chen, Y. Cao, J.-J. Chen, J.-Z. Chen, 2013
- Development for anticancer therapy small-molecule inhibitors targeting protein kinase B, S. Chen, J.-Z. Chen, 2013
- The agonist binding mechanism of human CB2 receptor studied by molecular dynamics simulation, free energy calculation and 3D-QSAR studies, J.-J. Chen, Shuang Han, Yang Cao, Jian-Zhong Chen, 2013
- Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives, L. Ou, S. Han, W. Ding, Z. Chen, Z. Ye, H. Yang, G. Zhang, Y. Lou, J.-Z. Chen, Y. Yu, 2011
- Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR, L. Ou, S. Han, W. Ding, P. Jia, B. Yang, J. L. Medina-Franco, M. A. Giulianotti, J.-Z. Chen, Y. Yu, 2011
- 3D-QSAR and docking studies of arylmethylamine-based DPP IV inhibitors, C. Jiang, S. Han, T. Chen, J.-Z. Chen, 2012
- New QSAR prediction models derived from GPCR CB2-antagonistic triaryl bis-sulfone analogues by a combined molecular morphological and pharmacophoric approach, J.-Z. Chen, K.-Z. Myint, X.-Q. Xie, 2011
- 创新药物转化研究中ADME 的评价, 刘瑶, 洪岚, 余露山, 蒋惠娣, 陈建忠, 孟琴, 陈枢青, 曾苏, 2011
- Beta-caryophyllene is a dietary cannabinoid, J. Gertsch, M. Leonti, S. Raduner, I. Racz, J.-Z. Chen, X.-Q. Xie, K.-H. Altmann, M. Karsak, A. Zimmer, 2008
- Data-Mining Representative Small Molecule Drug Screening Database from NIH PubChem, X.-Q. Xie, J.-Z. Chen, 2008
- Diverging Rh(I)-Catalyzed Carbocylization Strategy to Prepare a Library of Unique Cyclic Ethers, S. Mao, D. Probst, S. Werner, J.-Z. Chen, X. Xie, K. M. Brummond, 2008
- GPCR Structure-Based Virtual Screening Approach for CB2 Antagonist Search, J.-Z. Chen, J. Wang, X.-Q. Xie, 2007
- Alkylamides from Echinacea are a new class of cannabinomimetics. CB2-RECEPTOR DEPENDENT AND INDEPENDENT IMMUNOMODULATORY EFFECTS, S. Raduner, A. Majewska, J.-Z. Chen, X.-Q. Xie, J. Hamon, B. Faller, K.-H. Altmann, J. Gertsch, 2006
- 3D QSAR Studies of Arylpyrazole Antagonists of CB1 and CB2 Cannabinoid Receptors. A Combined NMR and CoMFA Approach, J.-Z. Chen, X.-W. Han, Q. Liu, A. Makriyannis, J. Wang, X.-Q. Xie, 2006
- NMR characterization of paclitaxel/poly (styrene-isobutylene-styrene) formulations, J.-Z. Chen, S. V. Ranade, X.-Q. Xie, 2005
- NMR structural comparison of the cytoplasmic juxtamembrane domains of G-protein coupled CB1 and CB2 receptors in membrane-mimetic DPC micelles, Xiang-Qun Xie, Jian-Zhong Chen, 2005
- Preferred conformations of endogenous cannabinoid ligand anandamide, J.-Z. Chen, X.-W. Han, X.-Q. Xie, 2005
- Synthesis and characterization of unsaturated thermotropic polyesters prepared via acyclic diene metathesis polymerization, H. Qin, B. J. Chakulski, I. A. Rousseau, J.-Z. Chen, X.-Q. Xie, P. T. G. S. Mather, Constable, Bryan E. Coughlin, 0200
Awards
- Second Prize of Natural Science Award, Chinese Academy of Sciences (1997)
