1989 - Bachelor's Degree in Chemistry: Hangzhou University
1995 - Master's Degree in Polymer Chemistry and Physics: Zhejiang University
2001 - Ph.D. in Medicinal Chemistry: Sichuan University
2003-2004 - Visiting Scholar: Gifu Pharmaceutical University, Japan
2015-2016 - Evaluator: China Food and Drug Administration
1996 - Lecturer: Zhejiang Medical University
2001 - Associate Professor: Zhejiang University
Research
Generic Drug Development New Drug Evaluation API Process Optimization Innovative Drug Development
Palladium-Catalyzed H/D Exchange Reaction with 8-Aminoquinoline as the Directing Group: Access to ortho-Selective Deuterated Aromatic Acids and β-Selective Deuterated Aliphatic Acids, Donghong Zhao, Haofan Luo, Binhui Chen, Wenteng Chen, Guolin Zhang, Yongping Yu, 2018
A three-component one-pot synthesis of penta-substituted pyrroles via ring opening of a-nitroepoxides, Zhao Donghong, Zhu Yue, Guo Shanshan, Chen Wenteng, Zhang Guolin, Yu Yongping, 2017
One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles, Guo Shanshan, Zhao Donghong, Zhu Yue, Yu Yongping, Chen Wenteng, Zhang Guolin, 2017
Manganese(II)-Mediated Domino Annulation Reaction of Vinyl Azides and 4-Hydroxycoumarin: A Stereoselective Synthesis of Spirobenzofuranone-lactams, Guo Shanshan, Chen Binhui, Zhao Donghong, Chen Wenteng, Zhang Guolin, 2016
Facile, efficient synthesis of polysubstituted thiazoles via α-nitroepoxides and thioureas, Zhao Donghong, Guo Shanshan, Guo Xiao, Zhang Guolin, Yongping Yu, 2016
6-Oxooxazolidine-quinazolines as noncovalent inhibitors with the potential to target mutant forms of EGFR, Shao Jiaan, Chen En, Shu Ke, Chen Wenteng, Zhang Guolin, Yongping Yu, 2016
Synthesis of Sotalol Hydrochloride, Sun Dengxue, Zhang Guolin, 2016
Iron(II)-Promoted Synthesis of 2-Aminothiazoles via C-N Bond Formation from Vinyl Azides and Potassium Thiocyanate, Zhang Guolin, Chen Binhui, Guo Xiao, Guo Shanshan, Yongping Yu, 2015
Selective access to 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles from vinyl azides and potassium thiocyanate switched by palladium and iron catalysts, Chen Binhui, Guo Shanshan, Guo Xiao, Zhang Guolin, Yongping Yu, 2015
One-Pot Three-Component Strategy for Functionalized 2-Aminoimidazoles via Ring Opening of α-Nitro Epoxides, Guo Xiao, Chen Wenteng, Chen Binhui, Huang Wei, Qi Weixing, Zhang Guolin, Yu Yongping, 2015
Mn(II)-catalyzed synthesis of benzo[f]indole-4,9-diones via vinyl azides and 2-hydroxynaphthoquinone, Guo Shanshan, Chen Binhui, Guo Xiao, Zhang Guolin, Yongping Yu, 2015
Vinyl Azides as Versatile Synthons for the Synthesis of Nitrogen-containing Heterocycles, Ni Hangcheng, Zhang Guolin, Yu Yongping, 2015
Synthesis and Process Research of Pregabalin, Yan Fengfeng, Zhang Guolin, 2015
Facile preparation of 3,5-disubstituted-4-aminothiophene-2-carbaldehyde from a novel unexpected domino reaction of vinyl azides and 1,4-dithiane-2,5-diol, Chen Binhui, Ni Hangcheng, Guo Xiao, Zhang Guolin, Yu Yongping, 2014
Facile, efficient synthesis of polyfunctionalized 2-aminoimidazoles via vinyl azides and cyanamide, Liu Shen, Shao Jiaan, Guo Xiao, Luo Jing, Zhao Menghao, Zhang Guolin, Yu Yongping, 2014
Simultaneous separation of apigenin, luteolin and rosmarinic acid from the aerial parts of the copper-tolerant plant Elsholtzia splendens, Peng Hongyun, Xing Yan, Gao Lingling, Zhang Liang, Zhang Guolin, 2014
Endothelium-dependent and -independent vasorelaxant actions and mechanisms induced by total flavonoids of Elsholtzia splendens in rat aortas, Wang Hui-Ping, Lu Jian-Feng, Zhang Guo-Lin, Li Xu-Yun, Peng Hong-Yun, Lu Yuan, Zhao Liang, Ye Zhi-Guo, Bruce Iain C, Xia Qiang, Qian Ling-Bo, 2014
A new strategy for facile synthesis of tetrasubstituted pyridine derivatives, Chen Jun, Ni Hangcheng, Chen Wenteng, Zhang Guolin, Yu Yongping, 2013
One-pot three-component approach to the synthesis of polyfunctional pyrazoles, Zhang Guolin, Ni Hangcheng, Chen Wenteng, Shao Jiaan, Liu Huan, Chen Binhui, Yongping Yu, 2013
One-pot synthesis of disubstituted imidazole derivatives from α-azidoketones catalyzed by potassium ethylxanthate, Chen Jun, Chen Wenteng, Yu Yongping, Zhang Guolin, 2013
Palladium-catalyzed synthesis of 3-alkenyl indoles from 2-azido-3-arylacrylates and terminal alkenes at room temperature, Zhang Yaohong, Liu Shen, Yu Wanwan, Hu Miao, Zhang Guolin, Yu Yongping, 2013
Protective effect of total flavonoids of Elsholtzia splendens on ischemia/reperfusion injury in isolated rat hearts, Zhao Liang, Li Zhi, Qian Lingbo, Ye Zhiguo, Zhang Guolin, Peng Hongyun, Xia Qiang, Wang Huiping, 2014
Area of Focus
Tumor | Pharmacology | Drug Mechanism | Innovative Drugs | Target Discovery | Protein Homeostasis | Toxicity Intervention | Cancer Research | Drug Development | Clinical Trials
Area of Focus
Drug Development | Clinical Needs | Chemiluminescence | Detection Kits | Drug Synthesis | Innovative Drugs | Clinical Trials | Pharmaceutical Research | Chemical Strategies | Lead Compounds
