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Guolin Zhang
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English
Generic Drugs
Drug Evaluation
Api
Process Optimization
Innovative Drugs
Pharmaceutical Chemistry
Synthesis
Clinical Trials
Patent
Research
Areas of Focus
- Generic Drug Development
- New Drug Evaluation
- API Process Optimization
- Innovative Drug Development
Work Experience
- 1996 - Lecturer: Zhejiang Medical University
- 2001 - Associate Professor: Zhejiang University
Academic Background & Achievements
- 1989 - Bachelor's Degree in Chemistry: Hangzhou University
- 1995 - Master's Degree in Polymer Chemistry and Physics: Zhejiang University
- 2001 - Ph.D. in Medicinal Chemistry: Sichuan University
- 2003-2004 - Visiting Scholar: Gifu Pharmaceutical University, Japan
- 2015-2016 - Evaluator: China Food and Drug Administration
Publications
- Palladium-Catalyzed H/D Exchange Reaction with 8-Aminoquinoline as the Directing Group: Access to ortho-Selective Deuterated Aromatic Acids and β-Selective Deuterated Aliphatic Acids, Donghong Zhao, Haofan Luo, Binhui Chen, Wenteng Chen, Guolin Zhang, Yongping Yu, 2018
- A three-component one-pot synthesis of penta-substituted pyrroles via ring opening of a-nitroepoxides, Zhao Donghong, Zhu Yue, Guo Shanshan, Chen Wenteng, Zhang Guolin, Yu Yongping, 2017
- One-pot three-component protocol for the synthesis of substituted 2-aminothiazoles, Guo Shanshan, Zhao Donghong, Zhu Yue, Yu Yongping, Chen Wenteng, Zhang Guolin, 2017
- Manganese(II)-Mediated Domino Annulation Reaction of Vinyl Azides and 4-Hydroxycoumarin: A Stereoselective Synthesis of Spirobenzofuranone-lactams, Guo Shanshan, Chen Binhui, Zhao Donghong, Chen Wenteng, Zhang Guolin, 2016
- Facile, efficient synthesis of polysubstituted thiazoles via α-nitroepoxides and thioureas, Zhao Donghong, Guo Shanshan, Guo Xiao, Zhang Guolin, Yongping Yu, 2016
- 6-Oxooxazolidine-quinazolines as noncovalent inhibitors with the potential to target mutant forms of EGFR, Shao Jiaan, Chen En, Shu Ke, Chen Wenteng, Zhang Guolin, Yongping Yu, 2016
- Synthesis of Sotalol Hydrochloride, Sun Dengxue, Zhang Guolin, 2016
- Iron(II)-Promoted Synthesis of 2-Aminothiazoles via C-N Bond Formation from Vinyl Azides and Potassium Thiocyanate, Zhang Guolin, Chen Binhui, Guo Xiao, Guo Shanshan, Yongping Yu, 2015
- Selective access to 4-substituted 2-aminothiazoles and 4-substituted 5-thiocyano-2-aminothiazoles from vinyl azides and potassium thiocyanate switched by palladium and iron catalysts, Chen Binhui, Guo Shanshan, Guo Xiao, Zhang Guolin, Yongping Yu, 2015
- One-Pot Three-Component Strategy for Functionalized 2-Aminoimidazoles via Ring Opening of α-Nitro Epoxides, Guo Xiao, Chen Wenteng, Chen Binhui, Huang Wei, Qi Weixing, Zhang Guolin, Yu Yongping, 2015
- Mn(II)-catalyzed synthesis of benzo[f]indole-4,9-diones via vinyl azides and 2-hydroxynaphthoquinone, Guo Shanshan, Chen Binhui, Guo Xiao, Zhang Guolin, Yongping Yu, 2015
- Vinyl Azides as Versatile Synthons for the Synthesis of Nitrogen-containing Heterocycles, Ni Hangcheng, Zhang Guolin, Yu Yongping, 2015
- Synthesis and Process Research of Pregabalin, Yan Fengfeng, Zhang Guolin, 2015
- Facile preparation of 3,5-disubstituted-4-aminothiophene-2-carbaldehyde from a novel unexpected domino reaction of vinyl azides and 1,4-dithiane-2,5-diol, Chen Binhui, Ni Hangcheng, Guo Xiao, Zhang Guolin, Yu Yongping, 2014
- Facile, efficient synthesis of polyfunctionalized 2-aminoimidazoles via vinyl azides and cyanamide, Liu Shen, Shao Jiaan, Guo Xiao, Luo Jing, Zhao Menghao, Zhang Guolin, Yu Yongping, 2014
- Simultaneous separation of apigenin, luteolin and rosmarinic acid from the aerial parts of the copper-tolerant plant Elsholtzia splendens, Peng Hongyun, Xing Yan, Gao Lingling, Zhang Liang, Zhang Guolin, 2014
- Endothelium-dependent and -independent vasorelaxant actions and mechanisms induced by total flavonoids of Elsholtzia splendens in rat aortas, Wang Hui-Ping, Lu Jian-Feng, Zhang Guo-Lin, Li Xu-Yun, Peng Hong-Yun, Lu Yuan, Zhao Liang, Ye Zhi-Guo, Bruce Iain C, Xia Qiang, Qian Ling-Bo, 2014
- A new strategy for facile synthesis of tetrasubstituted pyridine derivatives, Chen Jun, Ni Hangcheng, Chen Wenteng, Zhang Guolin, Yu Yongping, 2013
- One-pot three-component approach to the synthesis of polyfunctional pyrazoles, Zhang Guolin, Ni Hangcheng, Chen Wenteng, Shao Jiaan, Liu Huan, Chen Binhui, Yongping Yu, 2013
- One-pot synthesis of disubstituted imidazole derivatives from α-azidoketones catalyzed by potassium ethylxanthate, Chen Jun, Chen Wenteng, Yu Yongping, Zhang Guolin, 2013
- Palladium-catalyzed synthesis of 3-alkenyl indoles from 2-azido-3-arylacrylates and terminal alkenes at room temperature, Zhang Yaohong, Liu Shen, Yu Wanwan, Hu Miao, Zhang Guolin, Yu Yongping, 2013
- Protective effect of total flavonoids of Elsholtzia splendens on ischemia/reperfusion injury in isolated rat hearts, Zhao Liang, Li Zhi, Qian Lingbo, Ye Zhiguo, Zhang Guolin, Peng Hongyun, Xia Qiang, Wang Huiping, 2014
