Upload Avatar (500 x 500)
Chengliang Zhu
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: English, Chinese
Protein Degradation
Drug Discovery
Chemical Biology
Synthetic Lethality
E3 Ubiquitin Ligase
Cancer Research
Small Molecule Ligands
Computational Modeling
Organic Synthesis
Biological Pathways
Areas of Focus
- Drug Chemistry and Chemical Biology of Protein-Specific Degradation
Work Experience
- 2019.10-present - Zhejiang University - Distinguished Researcher
- 2018-2019 - Cornell University - Postdoctoral Researcher in Chemical Biology
- 2012-2017 - Georgia State University - Ph.D. in Organic Chemistry
- 2009-2012 - University of Nevada, Reno - Master's in Physical Organic Chemistry
- 2004-2008 - Hunan University - Bachelor's in Applied Chemistry
Academic Background & Achievements
- 2012-2017 Ph.D.: Georgia State University
- 2018-2019 Postdoctoral: Cornell University
- 2009-2012 Master's: University of Nevada, Reno
- 2004-2008 Bachelor's: Hunan University
- Doctoral Gold Award in Chemistry (Georgia State University, USA, 2017)
- The Chair’s Award (Georgia State University, USA, 2016)
- The Alfred R. Bader Award for Student Innovation (The Sigma-Aldrich Corporation, USA, 2015)
- The Chair’s Award (Chemistry Department, Georgia State University, 2014)
Publications
- PROTAC-mediated HDAC7 Protein Degradation Unveils Its Deacetylase-independent Proinflammatory Function in Macrophages, Kadier, K.; Niu, T.; Ding, B.; Chen, B.; Qi. X.; Chen, D.; Cheng, X.; Fang, Y.; Zhou, J.; Zhao, W.; Liu, Z.; Yuan, Y.; Zhou, Z.; Dong, X.; Yang, B.; He, Q.; Cao, J.; Jiang, L.; Zhu, C.-L., 2024
- Design, synthesis, and antitumor activity evaluation of potent fourth-generation EGFR inhibitors for treatment of Osimertinib resistant non-small cell lung cancer (NSCLC), Zhang, Y.; Tong, L.; Yan, F.; Huang, P.; Zhu, C.-L.; Pan, C., 2024
- STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice, Jiang, Y.; Xu Y.; Zhu, C.-L.; Xu, G.; Xu L.; Rao, Z.; Zhou, L.; Jiang, P.; Malik, S.; Fang, J.; Lin, H.; Zhang, M., 2023
- A practical preTACs-cytoblot platform accelerates the streamlined development of PROTAC-based protein degraders, Rao, Z.; Li K.; Hong, J.; Chen, D.; Ding, B.; Jiang, L.; Qi, X.; Hu, J.; Yang, B.; He, Q.; Dong, X.; Cao, J.; Zhu, C.-L., 2023
- The Role of Membrane-Associated E3 Ubiquitin Ligases in Cancer, Chen, X.; Jiang, L.; Zhou, Z.; Yang, B.; He, Q.; Zhu, C.-L.; Cao, J., 2022
- Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader, Zhu, C.-L.; Luo, X.; Tian, T.; Rao, Z.; Wang, H.; Zhou, Z.; Mi, T.; Chen, D.; Xu, Y.; Wu, Y.; Che, J.; Zhou, Y.; Li, J.; Dong, X., 2022
- Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor, Niu, T.; Li, K.; Jiang, L.; Zhou, Z.; Hong, J.; Chen, X.; Dong, X.; He, Q.; Cao, J.; Yang, B.; Zhu, C.-L., 2022
- Long-Chain Fatty Acyl Coenzyme A inhibits NME1/2 and regulates cancer metastasis, Zhang, S.; Nelson, O. D.; Price, I. R.; Zhu, C.-L.; Fernandez, I. R.; Lu, X.; Weiss, R. S.; Lin, H., 2022
- Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy, Li, K.; You, J.; Wu, Q.; Meng, W.; He, Q.; Yang, B.; Zhu, C.-L.; Cao, J., 2021
- High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases, Hong, J. Y.; Malgapo, M. I. P; Liu, Y.; Yang, M.; Zhu, C.-L.; Zhang, X.; Tolbert, P.; Linder, M. E.; Lin, H., 2021
- NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle, Kosciuk, T.; Price, I.R.; Zhang, X.; Zhu, C.-L.; Johnson, K.N.; Zhang, S.; Halaby, S.L.; Komaniecki, G.P.; Yang, M.; DeHart, C. J.; Thomas, P. M.; Kelleher, N.L.; Fromme, J.C.; Lin, H., 2020
- Activity-Guided Design of HDAC11-Specific Inhibitors, Son S.I.; Cao J.; Zhu, C.-L.; Miller S.P.; Lin H., 2019
- Direct Intermolecular Anti-Markovnikov Hydroazidation of Unactivated Olefins, Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H., 2019
- Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-Catalyzed Stereoselective Olefin Diazidation, Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H., 2018
- Iron(II)-Catalyzed Azidotrifluoromethylation of Olefins and N–Heterocycles for Expedient Vicinal Trifluoromethyl Amine Synthesis, Zhu, C.-L.; Wang. C.; Qin, Q.-X.; Yruegas, S.; Martin, C. D.; Xu, H., 2018
- Iron-Catalyzed Direct Olefin Diazidation via Peroxyester Activation Promoted by Nitrogen-Based Ligands, Shen, S.-J.; Zhu, C.-L.; Lu. D.-F.; Xu, H., 2018
- Iron(II) Bis(trifluoromethanesulfonyl)-imide, Zhu, C.-L.; Lu, D.-F.; Xu, H., 2017
- Iron(II)–Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion, Lu, D.-F.; Zhu, C.-L.; Sears, J. D.; Xu, H., 2016
- Practical Synthetic Procedures of the Iron–Catalyzed Intermolecular Olefin Aminohydroxylation Using Functionalized Hydroxylamines, Zhu, C.-L.; Lu, D.-F.; Sears, J. D.; Jia, Z.-X.; Xu, H., 2016
- Iron(II)–Catalyzed Asymmetric Intramolecular Olefin Aminochlorination with Chloride Ion, Zhu, C.-L.; Tian, J.-S.; Gu, Z.-Y.; Xing, G.-W.; Xu, H., 2015
- Iron–Catalyzed Diastereoselective Olefin Aminobromination with Bromide Ion, Tian, J.-S.; Zhu, C.-L.; Chen, Y.-R.; Xu, H., 2015
- Copper–Catalyzed Aerobic C-H Trifluoromethylation of Phenanthrolines, Zhu, C.-L.; Zhang, Y. Q.; Yuan, Y. A.; Xu, H., 2015
- Iron(II)–Catalyzed Intermolecular Amino-Oxygenation of Olefins through the N-O Bond Cleavage of Functionalized Hydroxylamines, Lu, D. F.; Zhu, C. -L.; Jia, Z. X.; Xu, H., 2014
- Iron (II)–Catalyzed Intramolecular Olefin Aminofluorination, Lu, D. F.; Liu, G. S.; Zhu, C. -L.; Yuan, B.; Xu, H., 2014
- Copper(I)–Catalyzed Diastereoselective Hydroxytrifluoromethylation of Dienes Accelerated by Phosphine Ligands, Lu, D. F.; Zhu, C. -L.; Xu, H., 2013
Awards
- Zhejiang Pharmaceutical Association Science and Technology Award First Prize (Fourth Contributor, 2023)
- Doctoral Gold Award in Chemistry (Georgia State University, USA, 2017)
- The Chair’s Award (Georgia State University, USA, 2016)
- The Alfred R. Bader Award for Student Innovation (The Sigma-Aldrich Corporation, USA, 2015)
- The Chair’s Award (Chemistry Department, Georgia State University, 2014)
