Professor | Chengliang Zhu | Asia Growth Partners

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Name	Chengliang Zhu
Contact Information	chengliangzhu@zju.edu.cn
Language ability	English, Chinese
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Chengliang Zhu

Contact Information

chengliangzhu@zju.edu.cn

Language ability

English, Chinese

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2012-2017 Ph.D.: Georgia State University 2018-2019 Postdoctoral: Cornell University 2009-2012 Master's: University of Nevada, Reno 2004-2008 Bachelor's: Hunan University Doctoral Gold Award in Chemistry (Georgia State University, USA, 2017) The Chair’s Award (Georgia State University, USA, 2016) The Alfred R. Bader Award for Student Innovation (The Sigma-Aldrich Corporation, USA, 2015) The Chair’s Award (Chemistry Department, Georgia State University, 2014)
Work Experience	2019.10-present - Zhejiang University - Distinguished Researcher 2018-2019 - Cornell University - Postdoctoral Researcher in Chemical Biology 2012-2017 - Georgia State University - Ph.D. in Organic Chemistry 2009-2012 - University of Nevada, Reno - Master's in Physical Organic Chemistry 2004-2008 - Hunan University - Bachelor's in Applied Chemistry
Awards	Zhejiang Pharmaceutical Association Science and Technology Award First Prize (Fourth Contributor, 2023) Doctoral Gold Award in Chemistry (Georgia State University, USA, 2017) The Chair’s Award (Georgia State University, USA, 2016) The Alfred R. Bader Award for Student Innovation (The Sigma-Aldrich Corporation, USA, 2015) The Chair’s Award (Chemistry Department, Georgia State University, 2014)

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2012-2017 Ph.D.: Georgia State University
2018-2019 Postdoctoral: Cornell University
2009-2012 Master's: University of Nevada, Reno
2004-2008 Bachelor's: Hunan University
Doctoral Gold Award in Chemistry (Georgia State University, USA, 2017)
The Chair’s Award (Georgia State University, USA, 2016)
The Alfred R. Bader Award for Student Innovation (The Sigma-Aldrich Corporation, USA, 2015)
The Chair’s Award (Chemistry Department, Georgia State University, 2014)

Work Experience

2019.10-present - Zhejiang University - Distinguished Researcher
2018-2019 - Cornell University - Postdoctoral Researcher in Chemical Biology
2012-2017 - Georgia State University - Ph.D. in Organic Chemistry
2009-2012 - University of Nevada, Reno - Master's in Physical Organic Chemistry
2004-2008 - Hunan University - Bachelor's in Applied Chemistry

Awards

Zhejiang Pharmaceutical Association Science and Technology Award First Prize (Fourth Contributor, 2023)
Doctoral Gold Award in Chemistry (Georgia State University, USA, 2017)
The Chair’s Award (Georgia State University, USA, 2016)
The Alfred R. Bader Award for Student Innovation (The Sigma-Aldrich Corporation, USA, 2015)
The Chair’s Award (Chemistry Department, Georgia State University, 2014)

Areas of Focus	Drug Chemistry and Chemical Biology of Protein-Specific Degradation
Publications	PROTAC-mediated HDAC7 Protein Degradation Unveils Its Deacetylase-independent Proinflammatory Function in Macrophages, Kadier, K.; Niu, T.; Ding, B.; Chen, B.; Qi. X.; Chen, D.; Cheng, X.; Fang, Y.; Zhou, J.; Zhao, W.; Liu, Z.; Yuan, Y.; Zhou, Z.; Dong, X.; Yang, B.; He, Q.; Cao, J.; Jiang, L.; Zhu, C.-L., 2024 Design, synthesis, and antitumor activity evaluation of potent fourth-generation EGFR inhibitors for treatment of Osimertinib resistant non-small cell lung cancer (NSCLC), Zhang, Y.; Tong, L.; Yan, F.; Huang, P.; Zhu, C.-L.; Pan, C., 2024 STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice, Jiang, Y.; Xu Y.; Zhu, C.-L.; Xu, G.; Xu L.; Rao, Z.; Zhou, L.; Jiang, P.; Malik, S.; Fang, J.; Lin, H.; Zhang, M., 2023 A practical preTACs-cytoblot platform accelerates the streamlined development of PROTAC-based protein degraders, Rao, Z.; Li K.; Hong, J.; Chen, D.; Ding, B.; Jiang, L.; Qi, X.; Hu, J.; Yang, B.; He, Q.; Dong, X.; Cao, J.; Zhu, C.-L., 2023 The Role of Membrane-Associated E3 Ubiquitin Ligases in Cancer, Chen, X.; Jiang, L.; Zhou, Z.; Yang, B.; He, Q.; Zhu, C.-L.; Cao, J., 2022 Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader, Zhu, C.-L.; Luo, X.; Tian, T.; Rao, Z.; Wang, H.; Zhou, Z.; Mi, T.; Chen, D.; Xu, Y.; Wu, Y.; Che, J.; Zhou, Y.; Li, J.; Dong, X., 2022 Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor, Niu, T.; Li, K.; Jiang, L.; Zhou, Z.; Hong, J.; Chen, X.; Dong, X.; He, Q.; Cao, J.; Yang, B.; Zhu, C.-L., 2022 Long-Chain Fatty Acyl Coenzyme A inhibits NME1/2 and regulates cancer metastasis, Zhang, S.; Nelson, O. D.; Price, I. R.; Zhu, C.-L.; Fernandez, I. R.; Lu, X.; Weiss, R. S.; Lin, H., 2022 Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy, Li, K.; You, J.; Wu, Q.; Meng, W.; He, Q.; Yang, B.; Zhu, C.-L.; Cao, J., 2021 High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases, Hong, J. Y.; Malgapo, M. I. P; Liu, Y.; Yang, M.; Zhu, C.-L.; Zhang, X.; Tolbert, P.; Linder, M. E.; Lin, H., 2021 NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle, Kosciuk, T.; Price, I.R.; Zhang, X.; Zhu, C.-L.; Johnson, K.N.; Zhang, S.; Halaby, S.L.; Komaniecki, G.P.; Yang, M.; DeHart, C. J.; Thomas, P. M.; Kelleher, N.L.; Fromme, J.C.; Lin, H., 2020 Activity-Guided Design of HDAC11-Specific Inhibitors, Son S.I.; Cao J.; Zhu, C.-L.; Miller S.P.; Lin H., 2019 Direct Intermolecular Anti-Markovnikov Hydroazidation of Unactivated Olefins, Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H., 2019 Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-Catalyzed Stereoselective Olefin Diazidation, Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H., 2018 Iron(II)-Catalyzed Azidotrifluoromethylation of Olefins and N–Heterocycles for Expedient Vicinal Trifluoromethyl Amine Synthesis, Zhu, C.-L.; Wang. C.; Qin, Q.-X.; Yruegas, S.; Martin, C. D.; Xu, H., 2018 Iron-Catalyzed Direct Olefin Diazidation via Peroxyester Activation Promoted by Nitrogen-Based Ligands, Shen, S.-J.; Zhu, C.-L.; Lu. D.-F.; Xu, H., 2018 Iron(II) Bis(trifluoromethanesulfonyl)-imide, Zhu, C.-L.; Lu, D.-F.; Xu, H., 2017 Iron(II)–Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion, Lu, D.-F.; Zhu, C.-L.; Sears, J. D.; Xu, H., 2016 Practical Synthetic Procedures of the Iron–Catalyzed Intermolecular Olefin Aminohydroxylation Using Functionalized Hydroxylamines, Zhu, C.-L.; Lu, D.-F.; Sears, J. D.; Jia, Z.-X.; Xu, H., 2016 Iron(II)–Catalyzed Asymmetric Intramolecular Olefin Aminochlorination with Chloride Ion, Zhu, C.-L.; Tian, J.-S.; Gu, Z.-Y.; Xing, G.-W.; Xu, H., 2015 Iron–Catalyzed Diastereoselective Olefin Aminobromination with Bromide Ion, Tian, J.-S.; Zhu, C.-L.; Chen, Y.-R.; Xu, H., 2015 Copper–Catalyzed Aerobic C-H Trifluoromethylation of Phenanthrolines, Zhu, C.-L.; Zhang, Y. Q.; Yuan, Y. A.; Xu, H., 2015 Iron(II)–Catalyzed Intermolecular Amino-Oxygenation of Olefins through the N-O Bond Cleavage of Functionalized Hydroxylamines, Lu, D. F.; Zhu, C. -L.; Jia, Z. X.; Xu, H., 2014 Iron (II)–Catalyzed Intramolecular Olefin Aminofluorination, Lu, D. F.; Liu, G. S.; Zhu, C. -L.; Yuan, B.; Xu, H., 2014 Copper(I)–Catalyzed Diastereoselective Hydroxytrifluoromethylation of Dienes Accelerated by Phosphine Ligands, Lu, D. F.; Zhu, C. -L.; Xu, H., 2013

Areas of Focus

Drug Chemistry and Chemical Biology of Protein-Specific Degradation

Publications

PROTAC-mediated HDAC7 Protein Degradation Unveils Its Deacetylase-independent Proinflammatory Function in Macrophages, Kadier, K.; Niu, T.; Ding, B.; Chen, B.; Qi. X.; Chen, D.; Cheng, X.; Fang, Y.; Zhou, J.; Zhao, W.; Liu, Z.; Yuan, Y.; Zhou, Z.; Dong, X.; Yang, B.; He, Q.; Cao, J.; Jiang, L.; Zhu, C.-L., 2024
Design, synthesis, and antitumor activity evaluation of potent fourth-generation EGFR inhibitors for treatment of Osimertinib resistant non-small cell lung cancer (NSCLC), Zhang, Y.; Tong, L.; Yan, F.; Huang, P.; Zhu, C.-L.; Pan, C., 2024
STAT3 palmitoylation initiates a positive feedback loop that promotes the malignancy of hepatocellular carcinoma cells in mice, Jiang, Y.; Xu Y.; Zhu, C.-L.; Xu, G.; Xu L.; Rao, Z.; Zhou, L.; Jiang, P.; Malik, S.; Fang, J.; Lin, H.; Zhang, M., 2023
A practical preTACs-cytoblot platform accelerates the streamlined development of PROTAC-based protein degraders, Rao, Z.; Li K.; Hong, J.; Chen, D.; Ding, B.; Jiang, L.; Qi, X.; Hu, J.; Yang, B.; He, Q.; Dong, X.; Cao, J.; Zhu, C.-L., 2023
The Role of Membrane-Associated E3 Ubiquitin Ligases in Cancer, Chen, X.; Jiang, L.; Zhou, Z.; Yang, B.; He, Q.; Zhu, C.-L.; Cao, J., 2022
Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader, Zhu, C.-L.; Luo, X.; Tian, T.; Rao, Z.; Wang, H.; Zhou, Z.; Mi, T.; Chen, D.; Xu, Y.; Wu, Y.; Che, J.; Zhou, Y.; Li, J.; Dong, X., 2022
Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor, Niu, T.; Li, K.; Jiang, L.; Zhou, Z.; Hong, J.; Chen, X.; Dong, X.; He, Q.; Cao, J.; Yang, B.; Zhu, C.-L., 2022
Long-Chain Fatty Acyl Coenzyme A inhibits NME1/2 and regulates cancer metastasis, Zhang, S.; Nelson, O. D.; Price, I. R.; Zhu, C.-L.; Fernandez, I. R.; Lu, X.; Weiss, R. S.; Lin, H., 2022
Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy, Li, K.; You, J.; Wu, Q.; Meng, W.; He, Q.; Yang, B.; Zhu, C.-L.; Cao, J., 2021
High-Throughput Enzyme Assay for Screening Inhibitors of the ZDHHC3/7/20 Acyltransferases, Hong, J. Y.; Malgapo, M. I. P; Liu, Y.; Yang, M.; Zhu, C.-L.; Zhang, X.; Tolbert, P.; Linder, M. E.; Lin, H., 2021
NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle, Kosciuk, T.; Price, I.R.; Zhang, X.; Zhu, C.-L.; Johnson, K.N.; Zhang, S.; Halaby, S.L.; Komaniecki, G.P.; Yang, M.; DeHart, C. J.; Thomas, P. M.; Kelleher, N.L.; Fromme, J.C.; Lin, H., 2020
Activity-Guided Design of HDAC11-Specific Inhibitors, Son S.I.; Cao J.; Zhu, C.-L.; Miller S.P.; Lin H., 2019
Direct Intermolecular Anti-Markovnikov Hydroazidation of Unactivated Olefins, Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H., 2019
Enantioselective Synthesis of Oseltamivir Phosphate (Tamiflu) via the Iron-Catalyzed Stereoselective Olefin Diazidation, Li, H.; Shen, S.-J.; Zhu, C.-L.; Xu, H., 2018
Iron(II)-Catalyzed Azidotrifluoromethylation of Olefins and N–Heterocycles for Expedient Vicinal Trifluoromethyl Amine Synthesis, Zhu, C.-L.; Wang. C.; Qin, Q.-X.; Yruegas, S.; Martin, C. D.; Xu, H., 2018
Iron-Catalyzed Direct Olefin Diazidation via Peroxyester Activation Promoted by Nitrogen-Based Ligands, Shen, S.-J.; Zhu, C.-L.; Lu. D.-F.; Xu, H., 2018
Iron(II) Bis(trifluoromethanesulfonyl)-imide, Zhu, C.-L.; Lu, D.-F.; Xu, H., 2017
Iron(II)–Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion, Lu, D.-F.; Zhu, C.-L.; Sears, J. D.; Xu, H., 2016
Practical Synthetic Procedures of the Iron–Catalyzed Intermolecular Olefin Aminohydroxylation Using Functionalized Hydroxylamines, Zhu, C.-L.; Lu, D.-F.; Sears, J. D.; Jia, Z.-X.; Xu, H., 2016
Iron(II)–Catalyzed Asymmetric Intramolecular Olefin Aminochlorination with Chloride Ion, Zhu, C.-L.; Tian, J.-S.; Gu, Z.-Y.; Xing, G.-W.; Xu, H., 2015
Iron–Catalyzed Diastereoselective Olefin Aminobromination with Bromide Ion, Tian, J.-S.; Zhu, C.-L.; Chen, Y.-R.; Xu, H., 2015
Copper–Catalyzed Aerobic C-H Trifluoromethylation of Phenanthrolines, Zhu, C.-L.; Zhang, Y. Q.; Yuan, Y. A.; Xu, H., 2015
Iron(II)–Catalyzed Intermolecular Amino-Oxygenation of Olefins through the N-O Bond Cleavage of Functionalized Hydroxylamines, Lu, D. F.; Zhu, C. -L.; Jia, Z. X.; Xu, H., 2014
Iron (II)–Catalyzed Intramolecular Olefin Aminofluorination, Lu, D. F.; Liu, G. S.; Zhu, C. -L.; Yuan, B.; Xu, H., 2014
Copper(I)–Catalyzed Diastereoselective Hydroxytrifluoromethylation of Dienes Accelerated by Phosphine Ligands, Lu, D. F.; Zhu, C. -L.; Xu, H., 2013

Protein Degradation Drug Discovery Chemical Biology Synthetic Lethality E3 Ubiquitin Ligase Cancer Research Small Molecule Ligands Computational Modeling Organic Synthesis Biological Pathways

Lu Zhou - Fudan University

Ke-Wu Zeng - Peking University

Zhengren Xu - Peking University

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