Professor | Lei Sun | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Lei Sun
Contact Information	llsun@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Lei Sun

Contact Information

llsun@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	2001-2006 PhD: Institute of Biophysics, Chinese Academy of Sciences 1997-2001 Bachelor: Department of Biological Sciences and Technology, Tsinghua University
Work Experience	2024-present - Fudan University, Institute of Biomedical Sciences/Shanghai Fifth People's Hospital - Researcher 2017-2023 - Fudan University, Institute of Biomedical Sciences/Shanghai Fifth People's Hospital - Young Researcher 2016-2017 - University of Texas Southwestern Medical Center - Research Assistant Professor 2010-2016 - Purdue University - Assistant Researcher 2006-2008 - Wageningen University - Postdoctoral Researcher

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

2001-2006 PhD: Institute of Biophysics, Chinese Academy of Sciences
1997-2001 Bachelor: Department of Biological Sciences and Technology, Tsinghua University

Work Experience

2024-present - Fudan University, Institute of Biomedical Sciences/Shanghai Fifth People's Hospital - Researcher
2017-2023 - Fudan University, Institute of Biomedical Sciences/Shanghai Fifth People's Hospital - Young Researcher
2016-2017 - University of Texas Southwestern Medical Center - Research Assistant Professor
2010-2016 - Purdue University - Assistant Researcher
2006-2008 - Wageningen University - Postdoctoral Researcher

Areas of Focus	Virus Structural Biology and Translational Medicine
Publications	TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry, Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L; Rao Z; Yang H, 2024 A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and Sarbecoviruses, Wang Y, Hao A, Ji P, Ma Y, Zhang Z, Chen J, Mao Q, Xiong X, Rehati P, Wang Y, Wang Y, Wen Y, Lu L, Chen Z, Zhao J; Wu F,; Huang J,; Sun L, 2024 Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3(KBTBD2), Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z, Beutler B, Sun L, 2024 Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination, Zhao X, Qiu T, Huang X, Mao Q, Wang Y, Qiao R, Li J, Mao T, Wang Y, Cun Y, Wang C, Luo C, Yoon C, Wang X, Li C, Cui Y, Zhao C, Li M, Chen Y, Cai G, Geng W, Hu Z, Cao J, Zhang W, Cao Z, Chu H, Sun L, Wang P, 2024 Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants, Hao A, Song W, Li C, Zhang X, Tu C, Wang X, Wang P, Wu Y, Ying T, Sun L, 2023 Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants, Wu J, Chen Z, Gao Y, Wang Z, Wang J, Chiang BY, Zhou Y, Han Y, Zhan W, Xie M, Jiang W, Zhang X, Hao A, Xia A, He J, Xue S, Mayer CT, Wu F, Wang B, Zhang L, Sun L, Wang Q, 2023 Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry, Wang H, Yang Q, Liu X, Xu Z, Shao M, Li D, Duan Y, Tang J, Yu X, Zhang Y, Hao A, Wang Y, Chen J, Zhu C, Guddat L, Chen H, Zhang L, Chen X, Jiang B, Sun L, Rao Z, Yang H, 2023 A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity, Ma Y, Mao Q, Wang Y, Zhang Z, Chen J, Hao A, Rehati P, Wang Y, Wen Y, Lu L, Chen Z, Zhao J, Wu F, Sun L, Huang J, 2023 Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger, Liu Q, Zhang X, Huang H, Chen Y, Wang F, Hao A, Zhan W, Mao Q, Hu Y, Han L, Sun Y, Zhang M, Liu Z, Li GL, Zhang W, Shu Y, Sun L, Chen Z, 2023 Characterization of cross-reactive monoclonal antibodies against SARS-CoV-1 and SARS-CoV-2: Implication for rational design and development of pan-sarbecovirus vaccines and neutralizing antibodies, Li S, Wu J, Jiang W, He H, Zhou Y, Wu W, Gao Y, Xie M, Xia A, He J, Zhang Q, Han Y, Wang N, Zhu G, Wang Q, Zhang Z, Mayer CT, Wang K, Wang X, Wang J, Chen Z, Jiang S, Sun L, Xia R, Wang Q, 2023 Expression, purification, and microscopic characterization of the tumor suppressor KLHL6, Han L, Chen Z, Sun L, 2023 Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer, Zhan W, Tian X, Zhang X, Xing S, Song W, Liu Q, Hao A, Hu Y, Zhang M, Ying T, Chen Z, Lan F, Sun L, 2022 Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody, Li C, Zhan W, Yang Z, Tu C, Hu G, Zhang X, Song W, Du S, Zhu Y, Huang K, Kong Y, Zhang M, Mao Q, Gu X, Zhang Y, Xie Y, Deng Q, Song Y, Chen Z, Lu L, Jiang S, Wu Y, Sun L, Ying T, 2022 Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies, Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L, Zhao J, Wu F, Chen Z, Huang J, 2022 A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding, Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J, Wu F, Sun L, Huang J, 2022 An ultrapotent pan-beta-coronavirus lineage B (beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope, Liu Z, Xu W, Chen Z, Fu W, Zhan W, Gao Y, Zhou J, Zhou Y, Wu J, Wang Q, Zhang X, Hao A, Wu W, Zhang Q, Li Y, Fan K, Chen R, Jiang Q, Mayer CT, Schoofs T, Xie Y, Jiang S, Wen Y, Yuan Z, Wang K, Lu L, Sun L, Wang Q, 2022 High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors, Zhao Y, Du X, Duan Y, Pan X, Sun Y, You T, Han L, Jin Z, Shang W, Yu J, Guo H, Liu Q, Wu Y, Peng C, Wang J, Zhu C, Yang X, Yang K, Lei Y, Guddat LW, Xu W, Xiao G, Sun L, Zhang L, Rao Z, Yang H, 2021 SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity, Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B, 2021 Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses, Hu Y, Sun L, 2019 Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-A resolution and its relevance to the assembly of icosahedral viruses, Chen Z, Sun L#, Zhang Z, Fokine A, Padilla-Sanchez V, Hanein D, Jiang W, Rossmann MG, Rao VB, 2017 The 3.8 A resolution cryo-EM structure of Zika virus, Sirohi D, Chen Z, Sun L#, Klose T, Pierson TC, Rossmann MG, Kuhn RJ, 2016 Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution, Sun L#, Zhang X, Gao S, Rao PA, Padilla-Sanchez V, Chen Z, Sun S, Xiang Y, Subramaniam S, Rao VB, Rossmann MG, 2015 Icosahedral bacteriophage PhiX174 forms a tail for DNA transport during infection, Sun L#, Young LN, Zhang X, Boudko SP, Fokine A, Zbornik E, Roznowski AP, Molineux IJ, Rossmann MG, Fane BA, 2014 High-resolution structure of a virally encoded DNA-translocating conduit and the mechanism of DNA penetration, Sun L#, Rossmann MG, Fane BA*, 2014

Areas of Focus

Virus Structural Biology and Translational Medicine

Publications

TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry, Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L*; Rao Z*; Yang H*, 2024
A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and Sarbecoviruses, Wang Y, Hao A, Ji P, Ma Y, Zhang Z, Chen J, Mao Q, Xiong X, Rehati P, Wang Y, Wang Y, Wen Y, Lu L, Chen Z, Zhao J*; Wu F,*; Huang J,*; Sun L*, 2024
Dynamic molecular architecture and substrate recruitment of cullin3-RING E3 ligase CRL3(KBTBD2), Hu Y, Zhang Z, Mao Q, Zhang X, Hao A, Xun Y, Wang Y, Han L, Zhan W, Liu Q, Yin Y, Peng C, Moresco EMY, Chen Z*, Beutler B*, Sun L*, 2024
Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination, Zhao X, Qiu T, Huang X, Mao Q, Wang Y, Qiao R, Li J, Mao T, Wang Y, Cun Y, Wang C, Luo C, Yoon C, Wang X, Li C, Cui Y, Zhao C, Li M, Chen Y, Cai G, Geng W, Hu Z, Cao J, Zhang W, Cao Z*, Chu H*, Sun L*, Wang P*, 2024
Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants, Hao A, Song W, Li C, Zhang X, Tu C, Wang X, Wang P, Wu Y*, Ying T*, Sun L*, 2023
Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants, Wu J, Chen Z, Gao Y, Wang Z, Wang J, Chiang BY, Zhou Y, Han Y, Zhan W, Xie M, Jiang W, Zhang X, Hao A, Xia A, He J, Xue S, Mayer CT, Wu F, Wang B, Zhang L*, Sun L*, Wang Q*, 2023
Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry, Wang H, Yang Q, Liu X, Xu Z, Shao M, Li D, Duan Y, Tang J, Yu X, Zhang Y, Hao A, Wang Y, Chen J, Zhu C, Guddat L, Chen H, Zhang L*, Chen X*, Jiang B*, Sun L*, Rao Z, Yang H*, 2023
A broadly neutralizing antibody inhibits SARS-CoV-2 variants through a novel mechanism of disrupting spike trimer integrity, Ma Y, Mao Q, Wang Y, Zhang Z, Chen J, Hao A, Rehati P, Wang Y, Wen Y, Lu L, Chen Z, Zhao J*, Wu F*, Sun L*, Huang J*, 2023
Asymmetric pendrin homodimer reveals its molecular mechanism as anion exchanger, Liu Q, Zhang X, Huang H, Chen Y, Wang F, Hao A, Zhan W, Mao Q, Hu Y, Han L, Sun Y, Zhang M, Liu Z, Li GL, Zhang W, Shu Y*, Sun L*, Chen Z*, 2023
Characterization of cross-reactive monoclonal antibodies against SARS-CoV-1 and SARS-CoV-2: Implication for rational design and development of pan-sarbecovirus vaccines and neutralizing antibodies, Li S, Wu J, Jiang W, He H, Zhou Y, Wu W, Gao Y, Xie M, Xia A, He J, Zhang Q, Han Y, Wang N, Zhu G, Wang Q, Zhang Z, Mayer CT, Wang K, Wang X, Wang J, Chen Z*, Jiang S*, Sun L*, Xia R*, Wang Q*, 2023
Expression, purification, and microscopic characterization of the tumor suppressor KLHL6, Han L, Chen Z, Sun L*, 2023
Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer, Zhan W, Tian X, Zhang X, Xing S, Song W, Liu Q, Hao A, Hu Y, Zhang M, Ying T*, Chen Z*, Lan F*, Sun L*, 2022
Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody, Li C, Zhan W, Yang Z, Tu C, Hu G, Zhang X, Song W, Du S, Zhu Y, Huang K, Kong Y, Zhang M, Mao Q, Gu X, Zhang Y, Xie Y, Deng Q, Song Y, Chen Z, Lu L, Jiang S, Wu Y*, Sun L*, Ying T*, 2022
Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies, Wang Y, Zhang X, Ma Y, Wang Y, Zhan W, Zheng Q, Zhang M, Ji P, Liu M, Liu Q, Sun T, Zhu T, Wen Y, Sun L*, Zhao J*, Wu F*, Chen Z*, Huang J*, 2022
A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding, Wang Y, Zhan W, Liu J, Wang Y, Zhang X, Zhang M, Han L, Ma Y, Lu L, Wen Y, Chen Z, Zhao J*, Wu F*, Sun L*, Huang J*, 2022
An ultrapotent pan-beta-coronavirus lineage B (beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope, Liu Z, Xu W, Chen Z, Fu W, Zhan W, Gao Y, Zhou J, Zhou Y, Wu J, Wang Q, Zhang X, Hao A, Wu W, Zhang Q, Li Y, Fan K, Chen R, Jiang Q, Mayer CT, Schoofs T, Xie Y, Jiang S, Wen Y, Yuan Z*, Wang K*, Lu L*, Sun L*, Wang Q*, 2022
High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors, Zhao Y, Du X, Duan Y, Pan X, Sun Y, You T, Han L, Jin Z, Shang W, Yu J, Guo H, Liu Q, Wu Y, Peng C, Wang J, Zhu C, Yang X, Yang K, Lei Y, Guddat LW, Xu W, Xiao G, Sun L*, Zhang L*, Rao Z*, Yang H*, 2021
SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity, Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B*, 2021
Systematic Analysis of Structure Similarity between Zika Virus and Other Flaviviruses, Hu Y, Sun L*, 2019
Cryo-EM structure of the bacteriophage T4 isometric head at 3.3-A resolution and its relevance to the assembly of icosahedral viruses, Chen Z, Sun L#, Zhang Z, Fokine A, Padilla-Sanchez V, Hanein D, Jiang W, Rossmann MG*, Rao VB*, 2017
The 3.8 A resolution cryo-EM structure of Zika virus, Sirohi D, Chen Z, Sun L#, Klose T, Pierson TC, Rossmann MG*, Kuhn RJ*, 2016
Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution, Sun L#, Zhang X, Gao S, Rao PA, Padilla-Sanchez V, Chen Z, Sun S, Xiang Y, Subramaniam S, Rao VB*, Rossmann MG*, 2015
Icosahedral bacteriophage PhiX174 forms a tail for DNA transport during infection, Sun L#, Young LN, Zhang X, Boudko SP, Fokine A, Zbornik E, Roznowski AP, Molineux IJ, Rossmann MG*, Fane BA*, 2014
High-resolution structure of a virally encoded DNA-translocating conduit and the mechanism of DNA penetration, Sun L#, Rossmann MG*, Fane BA*, 2014

Virus Structural Biology Translational Medicine Cryo-Em Molecular Biology Biochemistry Antiviral Strategies Pathogenic Viruses Antibody Design Vaccine Design

Alastair Murchie - Fudan University

Fei Chen - Fudan University

Qianhui Qu - Fudan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us