Professor | Faxing Yu | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Faxing Yu
Contact Information	fxyu@fudan.edu.cn
Language ability	English, Chinese
Province	Shanghai

Upload Avatar (500 x 500)

Name

Faxing Yu

Contact Information

fxyu@fudan.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	2010 - PhD: National University of Singapore, Department of Biochemistry 2004 - Bachelor's: National University of Singapore, Department of Biochemistry 2016 - Excellent Youth Fund, National Natural Science Foundation of China 2014 - Distinguished Professor, Shanghai Municipal Education Commission
Work Experience	2014.9 - Present - Fudan University, Institute of Biomedical Sciences - Researcher 2010.7 - 2014.9 - University of California, San Diego, Moores Cancer Center and Department of Pharmacology - Postdoctoral Fellow 2004.8 - 2010.2 - Institute of Molecular and Cell Biology, Singapore - Research Assistant
Awards	2016 - Excellent Youth Fund, National Natural Science Foundation of China 2014 - Distinguished Professor, Shanghai Municipal Education Commission

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

2010 - PhD: National University of Singapore, Department of Biochemistry
2004 - Bachelor's: National University of Singapore, Department of Biochemistry
2016 - Excellent Youth Fund, National Natural Science Foundation of China
2014 - Distinguished Professor, Shanghai Municipal Education Commission

Work Experience

2014.9 - Present - Fudan University, Institute of Biomedical Sciences - Researcher
2010.7 - 2014.9 - University of California, San Diego, Moores Cancer Center and Department of Pharmacology - Postdoctoral Fellow
2004.8 - 2010.2 - Institute of Molecular and Cell Biology, Singapore - Research Assistant

Awards

2016 - Excellent Youth Fund, National Natural Science Foundation of China
2014 - Distinguished Professor, Shanghai Municipal Education Commission

Areas of Focus	Hippo signaling pathway regulation Organ size regulation Mouse genetic models for cancer and therapy Cell population migration and tumor infiltration
Publications	The Hippo signaling pathway in development and regeneration, Zhong Z, Jiao Z, Yu FX, 2024 Angiomotin family proteins in the Hippo signaling pathway, Wang Y, Yu FX, 2024 Proteolytic activation of angiomotin by DDI2 promotes angiogenesis, Wang Y, Zhu Y, Wang Y, Chang Y, Geng F, Ma M, Gu Y, Yu A, Zhu R, Yu P, Sha Z, Qi S, Li J, Zhao W, Pan W, Zhang R, Yu FX, 2023 Two Hippo signaling modules orchestrate liver size and tumorigenesis, Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim DS, Mao J, Zhang L, Yu FX, 2023 TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis, Yu P, Qu N, Zhu R, Hu J, Han P, Wu J, Tan L, Gan H, He C, Fang C, Lei Y, Li J, He C, Lan F, Shi X, Wei W, Wang Y, Ji Q, Yu FX, Wang YL, 2023 Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development, Yu A, Yu P, Zhu Y, Zhu R, Sun R, Ye D, Yu FX, 2023 Reconstructing the Hippo signaling network, Zhong Z, Meng Z, Yu FX, 2023 Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis, Ma M, Zhong Z, Zhu Y, Gu Y, Jin R, Meng Z, Wang Y, Yu FX, 2023 Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers, Gu Y, Wang Y, Sha Z, He C, Zhu Y, Li J, Yu A, Zhong Z, Wang X, Sun Y, Lan F, Yu FX, 2022 WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy, Qi S, Zhu Y, Liu X, Li P, Wang Y, Zeng Y, Yu A, Wang Y, Sha Z, Zhong Z, Zhu R, Yuan H, Ye D, Huang S, Ling C, Xu Y, Zhou D, Zhang L, Yu, FX, 2022 Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis, Wang, Y., Zhu, Y., Gu, Y., Ma, M., Wang, Y., Qi, S., Zeng, Y., Zhu, R., Wang, X., Yu, P., Xu, J., Shu, Y., and Yu, FX, 2021 Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma, Li Y, Li J, Wang R, Zhang L, Fu G, Wang X, Wang Y, Fang C, Zhang D, Du D, Ma X, Pan M, Guo Q, Xu X, Hu X, Zhou Y, Mo S, Wang H, Gao J, Huang S, Liu Y, Cai S, Hua G, Peng J, Yu FX, 2020 USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer, Pan, B., Yang, Y., Li, J., Wang, Y., Fang, C., Yu, FX., & Xu, Y., 2020 An alternatively transcribed TAZ variant negatively regulates JAK-STAT signaling, Fang C, Li J, Qi S, Lei Y, Zeng Y, Yu P, Hu Z, Zhou Y, Wang Y, Dai R, Li J, Huang S, Xu P, Chen K, Ding C, Yu FX, 2019 Opposing roles of conventional and novel PKC in the Hippo-YAP pathway regulation, Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX,Xu Y, Guan KL, 2015 Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer, Yu FX, Zhao B, Guan KL*, 2015 Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP, Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL, 2014 Protein Kinase A activates the Hippo pathway to modulate cell proliferation and differentiation, Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL, 2013 Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling, Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mill GB, Guan KL, 2012

Areas of Focus

Hippo signaling pathway regulation
Organ size regulation
Mouse genetic models for cancer and therapy
Cell population migration and tumor infiltration

Publications

The Hippo signaling pathway in development and regeneration, Zhong Z, Jiao Z, Yu FX*, 2024
Angiomotin family proteins in the Hippo signaling pathway, Wang Y, Yu FX*, 2024
Proteolytic activation of angiomotin by DDI2 promotes angiogenesis, Wang Y, Zhu Y, Wang Y, Chang Y, Geng F, Ma M, Gu Y, Yu A, Zhu R, Yu P, Sha Z, Qi S, Li J, Zhao W, Pan W, Zhang R*, Yu FX*, 2023
Two Hippo signaling modules orchestrate liver size and tumorigenesis, Qi S, Zhong Z, Zhu Y, Wang Y, Ma M, Wang Y, Liu X, Jin R, Jiao Z, Zhu R, Sha Z, Dang K, Liu Y, Lim DS, Mao J, Zhang L, Yu FX*, 2023
TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis, Yu P, Qu N, Zhu R, Hu J, Han P, Wu J, Tan L, Gan H, He C, Fang C, Lei Y, Li J, He C, Lan F, Shi X, Wei W, Wang Y, Ji Q, Yu FX*, Wang YL*, 2023
Glucose-induced and ChREBP: MLX-mediated lipogenic program promotes hepatocellular carcinoma development, Yu A, Yu P, Zhu Y, Zhu R, Sun R, Ye D, Yu FX*, 2023
Reconstructing the Hippo signaling network, Zhong Z, Meng Z, Yu FX*, 2023
Phosphorylation of NF2 at Serine-13 by MAP4K family kinases mediates pathological angiogenesis, Ma M, Zhong Z, Zhu Y, Gu Y, Jin R, Meng Z, Wang Y*, Yu FX*, 2023
Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers, Gu Y, Wang Y, Sha Z, He C, Zhu Y, Li J, Yu A, Zhong Z, Wang X, Sun Y, Lan F, Yu FX*, 2022
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy, Qi S, Zhu Y, Liu X, Li P, Wang Y, Zeng Y, Yu A, Wang Y, Sha Z, Zhong Z, Zhu R, Yuan H, Ye D, Huang S, Ling C, Xu Y, Zhou D, Zhang L, Yu, FX*, 2022
Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis, Wang, Y., Zhu, Y., Gu, Y., Ma, M., Wang, Y., Qi, S., Zeng, Y., Zhu, R., Wang, X., Yu, P., Xu, J., Shu, Y., and Yu, FX*, 2021
Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma, Li Y, Li J, Wang R, Zhang L, Fu G, Wang X, Wang Y, Fang C, Zhang D, Du D, Ma X, Pan M, Guo Q, Xu X, Hu X, Zhou Y, Mo S, Wang H, Gao J, Huang S, Liu Y, Cai S, Hua G*, Peng J*, Yu FX*, 2020
USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer, Pan, B., Yang, Y., Li, J., Wang, Y., Fang, C., Yu, FX.*, & Xu, Y.*, 2020
An alternatively transcribed TAZ variant negatively regulates JAK-STAT signaling, Fang C, Li J, Qi S, Lei Y, Zeng Y, Yu P, Hu Z, Zhou Y, Wang Y, Dai R, Li J, Huang S, Xu P, Chen K, Ding C, Yu FX*, 2019
Opposing roles of conventional and novel PKC in the Hippo-YAP pathway regulation, Gong R, Hong AW, Plouffe SW, Zhao B, Liu G, Yu FX*,Xu Y*, Guan KL*, 2015
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer, Yu FX*, Zhao B, Guan KL*, 2015
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP, Yu FX, Luo J, Mo JS, Liu G, Kim YC, Meng Z, Zhao L, Peyman G, Ouyang H, Jiang W, Zhao J, Chen X, Zhang L, Wang CY, Bastian BC, Zhang K, Guan KL, 2014
Protein Kinase A activates the Hippo pathway to modulate cell proliferation and differentiation, Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL, 2013
Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling, Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mill GB, Guan KL, 2012

Hippo Signaling Organ Size Cancer Mouse Models Therapy Cell Migration Tumor Infiltration Biochemistry Cell Biology Genetics

Alastair Murchie - Fudan University

Fei Chen - Fudan University

Wenqiang Yu - Fudan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us