Itaconate Inhibits TET DNA Dioxygenases to Dampen Inflammatory Responses, Lei-Lei Chen, Carmen Morcelle, Zhou-Li Cheng, Xiufei Chen, Yanping Xu, Yajing Gao, Junbin Song, Zhijun Li, Matthew D. Smith, Miao Shi, Yezhang Zhu, Neng Zhou, Meng Cheng, Chenxi He, Kwei-Yan Liu, Guoping Lu, Lei Zhang, Chen Zhang, Jingye Zhang, Yiping Sun, Tuan Qi, Yingying Lyu, Zhi-Zhong Ren, Xian-Ming Tan, Jiayong Yin, Fei Lan, Ying Liu, Hui Yang, Maoxiang Qian, Caiwen Duan, Xing Chang, Yufeng Zhou, Li Shen, Albert S. Baldwin, Kun-Liang Guan, Yue Xiong, Dan Ye, 2022
Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity, Xiufei Chen, Wenjie Zhou, Ren-Hua Song, Shuang Liu, Shu Wang, Yujia Chen, Chao Gao, Chenxi He, Jianxiong Xiao, Lei Zhang, Tianxiang Wang, Peng Liu, Kunlong Duan, Zhouli Cheng, Chen Zhang, Jinye Zhang, Yiping Sun, Felix Jackson, Fei Lan, Yun Liu, Yanhui Xu, Justin Jong-Leong Wong, Pu Wang, Hui Yang, Yue Xiong, Tong Chen, Yan Li, Dan Ye, 2022
The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming, Cheng ZL, Zhang ML, Lin HP, Gao C, Song JB, Zheng Z, Li L, Zhang Y, Shen X, Zhang H, Huang Z, Zhan W, Zhang C, Hu X, Sun YP, Jiang L, Sun L, Xu Y, Yang C, Ge Y, Zhao Y, Liu X, Yang H, Liu P, Guo X, Guan KL, Xiong Y, Zhang M, Ye D, 2020
SNIP1 recruits TET2 to regulate c-MYC target genes and cellular DNA damage response, Lei-Lei Chen, Huai-Peng Lin, Wen-Jie Zhou, Chen-Xi He, Zhi-Yong Zhang, Zhou-Li Cheng, Jun-Bin Song, Peng Liu, Xin-Yu Chen, Yu-Kun Xia, Xiu-Fei Chen, Ren-Qiang Sun, Jing-Ye Zhang, Yi-Ping Sun, Lei Song, Bing-Jie Liu, Rui-Kai Du, Chen Ding, Fei Lan, Sheng-Lin Huang, Feng-Zhou, Su-Ling Liu, Yue Xiong, Dan Ye, Kun-Liang Guan, 2018
Metabolism, Activity, and Targeting of D-and L-2-Hydroxyglutarates, D Ye, KL Guan, Y Xiong, 2018
Destabilization of fatty acid synthase by acetylation inhibits de novo lipogenesis and tumor cell growth, Huai-Peng Lin, Zhou-Li Cheng, Ruo-Yu He, Lei Song, Meng-Xin Tian, Lisha Zhou, Beezly S. Groh, Weiren Liu, Min-Biao Ji, Chen Ding, Ying-Hong Shi, Kun-Liang Guan, Dan Ye, and Yue Xiong, 2016
Cancer: Suffocation of gene expression, Ye D, Xiong Y, 2016
Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents, Wang P, Wu J, Ma S-H, Zhang L, Yao J, Hoadley KA, Wilkerson MD, Perou CM, Guan K-L, Ye D, Xiong Y, 2015
Insulin and mTOR Pathway Regulate HDAC3-Mediated Deacetylation and Activation of PGK1, Wang S-W, Jiang B-W, Zhang T-F, Liu L-X, Wang Y, Wang Y-P, Chen X-F, Lin H-P, Zhou L-S, Xia Y-K, Chen L-L, Yang C, Xiong Y, Ye D, Guan K-L, 2015
SIRT3-dependent GOT2 acetylation enhances the malate-aspartate NADH shuttle activity to promote pancreatic tumor growth, Hui Yang, Lisha Zhou, Qian Shi, Yuzheng Zhao, Huaipeng Lin, Mengli Zhang, Yi Yang, Zhi-Qiang Ling, Kun-Liang Guan, Yue Xiong, and Dan Ye, 2015
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation, Wang Y-P, Xiao M-T, Chen X-F, Chen L-L, Xu Y-P, Lv L, Wang P, Yang H, Ma S-H, Lin H-P, Jiao B, Ren R-B, Ye D, Guan, K-L, and Xiong Y, 2015
Regulation of G6PD acetylation by KAT9/SIRT2 modulates NADPH homeostasis and cell survival during oxidative stress, Wang YP, Zhou LS, Zhao YZ, Wang SW, Chen LL, Liu LX, Ling ZQ, Hu FJ, Sun YP, Zhang JY, Yang C, Yang Y, Xiong Y, Guan KL, Ye D, 2014
TET-catalyzed 5-methylcytosine hydroxylation is dynamically regulated by metabolites, Yang H, Lin H-P, Xu H-Y, Zhang L, Cheng L, Wen B, Shou J-Y, Guan K-L, Xiong Y, Ye D, 2014
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation, Yang H, Liu Y, Bai F, Zhang J-Y, Ma S-H, Liu J, Xu Z-D, Zhu H-G, Ling Z-Q, Ye D, Guan K-L, and Xiong Y, 2013
R-2-Hydroxyglutarate as the Key Effector of IDH Mutations Promoting Oncogenesis, Ye D, Ma S-H, XiongY, GuanK-L, 2013
The mechanisms of IDH mutations in tumorigenesis, Ye D, Guan K-L, and Xiong Y, 2012
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors, Xiao M, Yang H, Xu W, Ma S, Lin H, Zhu H, Liu L, Liu Y, Yang C, Xu Y, Zhao S, Ye D, Xiong Y, Guan KL, 2012
