Professor | Duan Ma | Asia Growth Partners

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Name	Duan Ma
Contact Information	duanma@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Duan Ma

Contact Information

duanma@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	1995-1998 PhD: Shanghai Medical University, Molecular Genetics (Biochemistry and Molecular Biology) 1985-1988 Master's: Shandong Medical University, Internal Medicine Hematology 1979-1982 Bachelor's: Wuhan University of Science and Technology, Medical Department 2013 Shanghai Leading Talent 2012 Shanghai Outstanding Academic Leader 2002 Shanghai Dawn Scholar
Work Experience	2008-present - Fudan University Birth Defect Research Center - Deputy Director 2002.3-present - Fudan University Key Laboratory of Molecular Medicine - Professor/Deputy Director 2000-2002 - University of New Mexico School of Medicine - Postdoctoral Fellow 1998-2000 - Chinese Academy of Medical Sciences/Peking Union Medical College Hospital - Postdoctoral Fellow 1989-2000 - Shandong Thrombosis Research Center - Director/Deputy Director 1983-1985 - Anyang Iron and Steel Company Lizhen Iron Mine Staff Hospital - Resident Physician
Awards	2015 China Maternal and Child Health Science and Technology Award First Prize 2014 East China Science and Technology Press Excellent Science and Technology Book First Prize, Clinical Genetics 2014 Shanghai Book Award First Prize, Clinical Genetics 2008 Shanghai Excellent Book First Prize, Application of Frontier Technology in Biology to Medical Research 2006 Shanghai Fourth Xu Guangqi Science and Technology Silver Award 2004 Shanghai Bioengineering Society Honorary Award 2003 Shanghai Science and Technology Progress Third Prize 2002 Shanghai Excellent Invention Selection Competition First Prize

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

1995-1998 PhD: Shanghai Medical University, Molecular Genetics (Biochemistry and Molecular Biology)
1985-1988 Master's: Shandong Medical University, Internal Medicine Hematology
1979-1982 Bachelor's: Wuhan University of Science and Technology, Medical Department
2013 Shanghai Leading Talent
2012 Shanghai Outstanding Academic Leader
2002 Shanghai Dawn Scholar

Work Experience

2008-present - Fudan University Birth Defect Research Center - Deputy Director
2002.3-present - Fudan University Key Laboratory of Molecular Medicine - Professor/Deputy Director
2000-2002 - University of New Mexico School of Medicine - Postdoctoral Fellow
1998-2000 - Chinese Academy of Medical Sciences/Peking Union Medical College Hospital - Postdoctoral Fellow
1989-2000 - Shandong Thrombosis Research Center - Director/Deputy Director
1983-1985 - Anyang Iron and Steel Company Lizhen Iron Mine Staff Hospital - Resident Physician

Awards

2015 China Maternal and Child Health Science and Technology Award First Prize
2014 East China Science and Technology Press Excellent Science and Technology Book First Prize, Clinical Genetics
2014 Shanghai Book Award First Prize, Clinical Genetics
2008 Shanghai Excellent Book First Prize, Application of Frontier Technology in Biology to Medical Research
2006 Shanghai Fourth Xu Guangqi Science and Technology Silver Award
2004 Shanghai Bioengineering Society Honorary Award
2003 Shanghai Science and Technology Progress Third Prize
2002 Shanghai Excellent Invention Selection Competition First Prize

Areas of Focus	Etiology, pathogenesis, early prevention and clinical translation of birth defects and genetic-related diseases
Publications	Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study, Yang F, Chen C, Zhou Q, Gong Y, Li R, Li C, Klämpfl F, Freund S, Wu X, Sun Y, Li X, Schmidt M, Ma D, Yu Y, 2017 A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer, Ma J, Yang J, Jian W, Wang X, Xiao D, Xia W, Xiong L, Ma D, 2017 Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway, Xiao JJ, Jin KY, Wang JP, Ma J, Zhang J, Jiang N, Wang HJ, Luo XP, Fei J, Wang ZG, Yang X, Ma D, 2017 SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss, Ma Z, Xia W, Liu F, Ma J, Sun S, Zhang J, Jiang N, Wang X, Hu J, Ma D, 2016 Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice, Wang J, Xiao J, Wen D, Wu X, Mao Z, Zhang J, Ma D, 2016 Chronic exposure to ethanol in male mice may be associated with hearing loss in offspring, Liang F, Diao L, Jiang N, Zhang J, Wang HJ, Zhou WH, Huang GY, Ma D, 2015 Grhl1 deficiency affects inner ear development in zebrafish, Liu F, Yang F, Wen D, Xia W, Hao L, Hu J, Zong J, Shen X, Ma J, Jiang N, Sun S, Zhang J, Wang H, Wang X, Ma Z, Ma D, 2015 Comparison of the performance of Ion Torrent chips in noninvasive prenatal trisomy detection, Wang Y, Wen Z, Shen J, Cheng W, Li J, Qin X, Ma D, Shi Y, 2014 Paternal ethanol exposure and behavioral abnormities in offspring: Associated alterations in imprinted gene methylation, Liang F, Diao L, Liu J, Jiang N, Zhang J, Wang H, Zhou W, Huang G, Ma D, 2014 Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/β-catenin signalling pathway by directly binding casein kinase 1ε, Xu F, Wang YL, Chang JJ, Du SC, Diao L, Jiang N, Wang H, Ma D, Zhang J, 2014 MicroRNA deregulation in right ventricular outflow tract myocardium in nonsyndromic tetralogy of fallot, Zhang J, Luo X, Ma XJ, Wu Y, Li WC, Wang HJ, Huang GY, Ma D, 2013 Tissue factor pathway inhibitor-2: A novel gene involved in zebrafish central nervous system development, Zhang YL, Wang LN, Zhou WH, Zhang J, Wang HJ, Jiang Q, Deng SS, Li WH, Wang L, Li HW, Mao ZH, Ma D, 2013 Roles of miR-1-1 and miR-181c in ventricular septal defects, Li J, Cao Y, Ma XJ, Wang HJ, Zhang J, Luo X, Chen W, Wu Y, Meng Y, Zhang J, Yuan Y, Ma D, Huang GY, 2013 LINE-1Methylation Status and Its Association with Tetralogy of Fallot in Chinese Infants, Sheng W, Wang HJ, Zhang P, Qian YY, Wu Y, Ma XJ, Zheng FY, Chen L, Huang GY, Ma D, 2012 miRNA-135a promotes migration and invasion of breast cancer by targeting HOXA10, Chen YT, Zhang J, Wang HJ, Xu C, Du YY, Luo X, Zheng FY, Zhao JY, Zhang HW, Ma D, 2012 The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells, Xu C, Deng F, Mao Z, Zhang J, Wang H, Wang J, Mu J, Deng S, Ma D, 2012 The cell growth suppressor, mir-126, targets IRS-1, Zhang J, Du YY, Lin YF, Chen YT, Yang L, Wang HJ, Ma D, 2008 Tissue factor pathway inhibitor-2 could be repressed by CpG hypermethylation through inhibition of KLF6 binding in high metastatic breast cancer cell MDA-MB-435, Guo HS, Kong DS, Lin YF, Zhang HW, Liu J, Zhang N, Song HY, Tang QQ, Ma D, 2007 Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway, Lin YF, Zhang N, Guo HS, Kong DS, Jiang T, Liang W, Zhao ZH, Liu J, Tang QQ, Ma D, 2007 Molecular Design and Characterization of Recombinant Long Half-life Human Tissue Factor Pathway Inhibitor Mutants, Bai H, Ma D, Zhang YG, Zhang N, Kong DS, Guo HS, Mo W, Tang QQ, Song HY, 2005 New role of LRP5, associated with non-syndromic autosomal recessive hereditary hearing loss, Xia W, Hu J, Liu F, Ma J, Sun S, Zhang J, Jin K, Huang J, Jiang N, Wang X, Li W, Ma Z, Ma D, 2017 Hypomethylation and decreased expression of BRG1 in the myocardium of patients with congenital heart disease, Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H, 2017 MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239, Shi Q, Xiong B, Zhong J, Wang H, Ma D, Miao C, 2017 Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis, Yang J, Jin K, Xiao J, Ma J, Ma D, 2017 Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways, Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, Weng M, Shi Q, Ma D, Miao C, 2017 Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation, Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H, 2017 Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and

Areas of Focus

Etiology, pathogenesis, early prevention and clinical translation of birth defects and genetic-related diseases

Publications

Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and photoelastic study, Yang F, Chen C, Zhou Q, Gong Y, Li R, Li C, Klämpfl F, Freund S, Wu X, Sun Y, Li X, Schmidt M, Ma D, Yu Y, 2017
A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer, Ma J, Yang J, Jian W, Wang X, Xiao D, Xia W, Xiong L, Ma D, 2017
Conditional knockout of TFPI-1 in VSMCs of mice accelerates atherosclerosis by enhancing AMOT/YAP pathway, Xiao JJ, Jin KY, Wang JP, Ma J, Zhang J, Jiang N, Wang HJ, Luo XP, Fei J, Wang ZG, Yang X, Ma D, 2017
SLC44A4 mutation causes autosomal dominant hereditary postlingual non-syndromic mid-frequency hearing loss, Ma Z, Xia W, Liu F, Ma J, Sun S, Zhang J, Jiang N, Wang X, Hu J, Ma D, 2016
Endothelial cell-anchored tissue factor pathway inhibitor regulates tumor metastasis to the lung in mice, Wang J, Xiao J, Wen D, Wu X, Mao Z, Zhang J, Ma D, 2016
Chronic exposure to ethanol in male mice may be associated with hearing loss in offspring, Liang F, Diao L, Jiang N, Zhang J, Wang HJ, Zhou WH, Huang GY, Ma D, 2015
Grhl1 deficiency affects inner ear development in zebrafish, Liu F, Yang F, Wen D, Xia W, Hao L, Hu J, Zong J, Shen X, Ma J, Jiang N, Sun S, Zhang J, Wang H, Wang X, Ma Z, Ma D, 2015
Comparison of the performance of Ion Torrent chips in noninvasive prenatal trisomy detection, Wang Y, Wen Z, Shen J, Cheng W, Li J, Qin X, Ma D, Shi Y, 2014
Paternal ethanol exposure and behavioral abnormities in offspring: Associated alterations in imprinted gene methylation, Liang F, Diao L, Liu J, Jiang N, Zhang J, Wang H, Zhou W, Huang G, Ma D, 2014
Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/β-catenin signalling pathway by directly binding casein kinase 1ε, Xu F, Wang YL, Chang JJ, Du SC, Diao L, Jiang N, Wang H, Ma D, Zhang J, 2014
MicroRNA deregulation in right ventricular outflow tract myocardium in nonsyndromic tetralogy of fallot, Zhang J, Luo X, Ma XJ, Wu Y, Li WC, Wang HJ, Huang GY, Ma D, 2013
Tissue factor pathway inhibitor-2: A novel gene involved in zebrafish central nervous system development, Zhang YL, Wang LN, Zhou WH, Zhang J, Wang HJ, Jiang Q, Deng SS, Li WH, Wang L, Li HW, Mao ZH, Ma D, 2013
Roles of miR-1-1 and miR-181c in ventricular septal defects, Li J, Cao Y, Ma XJ, Wang HJ, Zhang J, Luo X, Chen W, Wu Y, Meng Y, Zhang J, Yuan Y, Ma D, Huang GY, 2013
LINE-1Methylation Status and Its Association with Tetralogy of Fallot in Chinese Infants, Sheng W, Wang HJ, Zhang P, Qian YY, Wu Y, Ma XJ, Zheng FY, Chen L, Huang GY, Ma D, 2012
miRNA-135a promotes migration and invasion of breast cancer by targeting HOXA10, Chen YT, Zhang J, Wang HJ, Xu C, Du YY, Luo X, Zheng FY, Zhao JY, Zhang HW, Ma D, 2012
The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells, Xu C, Deng F, Mao Z, Zhang J, Wang H, Wang J, Mu J, Deng S, Ma D, 2012
The cell growth suppressor, mir-126, targets IRS-1, Zhang J, Du YY, Lin YF, Chen YT, Yang L, Wang HJ, Ma D, 2008
Tissue factor pathway inhibitor-2 could be repressed by CpG hypermethylation through inhibition of KLF6 binding in high metastatic breast cancer cell MDA-MB-435, Guo HS, Kong DS, Lin YF, Zhang HW, Liu J, Zhang N, Song HY, Tang QQ, Ma D, 2007
Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway, Lin YF, Zhang N, Guo HS, Kong DS, Jiang T, Liang W, Zhao ZH, Liu J, Tang QQ, Ma D, 2007
Molecular Design and Characterization of Recombinant Long Half-life Human Tissue Factor Pathway Inhibitor Mutants, Bai H, Ma D, Zhang YG, Zhang N, Kong DS, Guo HS, Mo W, Tang QQ, Song HY, 2005
New role of LRP5, associated with non-syndromic autosomal recessive hereditary hearing loss, Xia W, Hu J, Liu F, Ma J, Sun S, Zhang J, Jin K, Huang J, Jiang N, Wang X, Li W, Ma Z, Ma D, 2017
Hypomethylation and decreased expression of BRG1 in the myocardium of patients with congenital heart disease, Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H, 2017
MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239, Shi Q, Xiong B, Zhong J, Wang H, Ma D, Miao C, 2017
Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis, Yang J, Jin K, Xiao J, Ma J, Ma D, 2017
Ubiquitylation of MFHAS1 by the ubiquitin ligase praja2 promotes M1 macrophage polarization by activating JNK and p38 pathways, Zhong J, Wang H, Chen W, Sun Z, Chen J, Xu Y, Weng M, Shi Q, Ma D, Miao C, 2017
Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation, Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, Huang G, Ma D, Wang H, 2017
Laser beam melting 3D printing of Ti6Al4V based porous structured dental implants: fabrication, biocompatibility analysis and

Birth Defects Genetic Diseases Etiology Pathogenesis Early Prevention Clinical Translation Genetics Molecular Biology Biochemistry Medical Research

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