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Yihua Huang
Life Science
University of Chinese Academy of Sciences
Beijing
Language: English, Chinese
Membrane
Protein
Structure
Biology
X-Ray
Crystallography
Biogenesis
Mechanism
Function
Transport
Areas of Focus
- Membrane Protein Structural Biology
Work Experience
- 2010.9-Present - Institute of Biophysics, Chinese Academy of Sciences - Research Group Leader
- 2004.3-2010.8 - UT Southwestern Medical Center at Dallas/HHMI - Postdoctoral Fellow/Assistant Researcher/Lecturer
Academic Background & Achievements
- 1998-07--2004-02 Ph.D.: Cornell University
- 1995-09--1998-07 Master's Degree: Peking University
- 1990-09--1995-07 Bachelor's Degree: Peking University
Publications
- Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins, Han L, Zheng J, Wang Y, Yang X, Liu Y, Sun C, Cao B, Zhou H, Ni D, Lou J, Zhao Y, Huang Y, 2016
- The Expression, Purification, and Structure Determination of BamA from E. coli, Ni D, Huang Y, 2015
- Structure of the nonameric bacterial amyloid secretion channel, Cao B, Zhao Y, Kou Y, Ni D, Zhang XC, Huang Y, 2014
- Structural basis for lipopolysaccharide insertion in the bacterial outer membrane, Qiao S, Luo Q, Zhao Y, Zhang XC, Huang Y, 2014
- Refolding, crystallization and preliminary X-ray crystallographic studies of the β-barrel domain of BamA, a membrane protein essential for outer membrane protein biogenesis, Ni D, Yang K, Huang Y, 2014
- Structural and functional analysis of the β-barrel domain of BamA from Escherichia coli, Ni D, Wang Y, Yang X, Zhou H, Hou X, Cao B, Lu Z, Zhao X, Yang K, Huang Y, 2014
- Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC, Huang Y, Smith B, Chen L, Baxter R, Deisenhofer J, 2009
- Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implication for photolyase activity, Huang Y, Baxter R, Smith BS, Partch CL, Colbert CL, Deisenhofer J, 2006
- Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain, Huang Y, Park YC, Rich RL, Segal D, Myszka DG, Wu H, 2001
- Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac, Huang Y, Rich R, Myszkat D, Wu H, 2003
- Antagonizing XIAP-mediated caspase-3 inhibition: Achilles' heel of cancers?, Huang Y, Lu M, Wu H, 2004
- Covalent inhibition revealed by the crystal structure of the p35/caspase-8 complex, Xu G, Cirilli M, Huang Y, Rich RL, Myszka DG, Wu H, 2001
- Crystal structure of the BIR1 domain of XIAP In two crystal forms, Lin SC, Huang Y, Lo YC, Lu M, Wu H, 2007
- XIAP induces NF-κB activation via the BIR1/TAB1 interaction and BIR1 dimerization, Lu M, Lin S, Huang Y, Kang YJ, Rich R, Lo YC, Myszka D, Han J, Wu H, 2007
- Mutational analysis of the p35-caspase interaction: A bowstring kinetic model of caspase inhibition by p35, Xu G, Rich RL, Steegborn C, Min T, Huang Y, Myszka DG, Wu H, 2003
- Calcium dependence of myocardial hypothermial tolerance on sources of activator, Wang S, Huang Y, Zhou Z, 1997
