Professor | Si Wu | Asia Growth Partners

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Name	Si Wu
Contact Information	wusi@moon.ibp.ac.cn
Language ability	Chinese, English
Province	Beijing

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Name

Si Wu

Contact Information

wusi@moon.ibp.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2005-09--2011-01 PhD: Peking University 2001-09--2005-07 Bachelor: Nankai University
Work Experience	2023-01~Present - Chinese Academy of Sciences, Institute of Biophysics - Researcher 2014-01~2022-12 - Chinese Academy of Sciences, Institute of Biophysics - Associate Researcher 2011-03~2013-12 - Chinese Academy of Sciences, Institute of Biophysics - Assistant Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2005-09--2011-01 PhD: Peking University
2001-09--2005-07 Bachelor: Nankai University

Work Experience

2023-01~Present - Chinese Academy of Sciences, Institute of Biophysics - Researcher
2014-01~2022-12 - Chinese Academy of Sciences, Institute of Biophysics - Associate Researcher
2011-03~2013-12 - Chinese Academy of Sciences, Institute of Biophysics - Assistant Researcher

Areas of Focus	Single-Molecule Biophysics
Publications	Reversible Redox-Dependent Conformational Switch of the C-Terminal alpha-Helical Lid of Human Hsp70 Observed by In-Cell NMR, 4th Author, 2023 Effect of evolution of the C-terminal region on chaperone activity of Hsp70, 3rd Author, 2023 Methylene blue accelerates liquid-to-gel transition of Tau condensates: impacts on functional and pathological roles of Tau, 16th Author, 2023 Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, 3rd Author, 2023 蛋白质错误折叠相关疾病的多肽药物研究进展, 11th Author, 2022 Peptide-based Strategies for Treatment of Protein Misfolding Diseases, 11th Author, 2022 Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation, 11th Author, 2022 Hsp70 in Redox Homeostasis, 3rd Author, 2022 Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis, 11th Author, 2022 Single Molecule Characterization of Amyloid Oligomers, 11th Author, 2021 PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, 3rd Author, 2021 Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation, 11th Author, 2021 Studying protein folding in health and disease using biophysical approaches, Not mentioned, 2021 S -Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, 9th Author, 2020 Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis, 11th Author, 2020 Kinetic diversity of amyloid oligomers, 5th Author, 2020 Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, 1st Author, 2020 Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils, 11th Author, 2020 Protein Microgels from Amyloid Fibril Networks, 3rd Author, 2019 Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2, 11th Author, 2018 The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast, 5th Author, 2018 Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling, 7th Author, 2018 A co-expression strategy to achieve labeling of individual subunits within a dimeric protein for single molecule analysis, 11th Author, 2017 Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response, 3rd Author, 2016 Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry, 4th Author, 2015 Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2, 2nd Author, 2013

Areas of Focus

Single-Molecule Biophysics

Publications

Reversible Redox-Dependent Conformational Switch of the C-Terminal alpha-Helical Lid of Human Hsp70 Observed by In-Cell NMR, 4th Author, 2023
Effect of evolution of the C-terminal region on chaperone activity of Hsp70, 3rd Author, 2023
Methylene blue accelerates liquid-to-gel transition of Tau condensates: impacts on functional and pathological roles of Tau, 16th Author, 2023
Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, 3rd Author, 2023
蛋白质错误折叠相关疾病的多肽药物研究进展, 11th Author, 2022
Peptide-based Strategies for Treatment of Protein Misfolding Diseases, 11th Author, 2022
Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation, 11th Author, 2022
Hsp70 in Redox Homeostasis, 3rd Author, 2022
Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis, 11th Author, 2022
Single Molecule Characterization of Amyloid Oligomers, 11th Author, 2021
PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, 3rd Author, 2021
Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation, 11th Author, 2021
Studying protein folding in health and disease using biophysical approaches, Not mentioned, 2021
S -Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, 9th Author, 2020
Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis, 11th Author, 2020
Kinetic diversity of amyloid oligomers, 5th Author, 2020
Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, 1st Author, 2020
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils, 11th Author, 2020
Protein Microgels from Amyloid Fibril Networks, 3rd Author, 2019
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2, 11th Author, 2018
The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast, 5th Author, 2018
Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling, 7th Author, 2018
A co-expression strategy to achieve labeling of individual subunits within a dimeric protein for single molecule analysis, 11th Author, 2017
Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response, 3rd Author, 2016
Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry, 4th Author, 2015
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2, 2nd Author, 2013

Single-Molecule Biophysics Hsp70 Protein Misfolding Amyloid Tau Nmr Chaperone Protein Folding Redox Homeostasis

Shen Wang - Huazhong University of Science and Technology

Sarah Perrett - University of Chinese Academy of Sciences

Liangyu Huang - University of Chinese Academy of Sciences

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