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Si Wu
Life Science
University of Chinese Academy of Sciences
Beijing
Language: Chinese, English
Single-Molecule
Biophysics
Hsp70
Protein Misfolding
Amyloid
Tau
Nmr
Chaperone
Protein Folding
Redox Homeostasis
Areas of Focus
- Single-Molecule Biophysics
Work Experience
- 2023-01~Present - Chinese Academy of Sciences, Institute of Biophysics - Researcher
- 2014-01~2022-12 - Chinese Academy of Sciences, Institute of Biophysics - Associate Researcher
- 2011-03~2013-12 - Chinese Academy of Sciences, Institute of Biophysics - Assistant Researcher
Academic Background & Achievements
- 2005-09--2011-01 PhD: Peking University
- 2001-09--2005-07 Bachelor: Nankai University
Publications
- Reversible Redox-Dependent Conformational Switch of the C-Terminal alpha-Helical Lid of Human Hsp70 Observed by In-Cell NMR, 4th Author, 2023
- Effect of evolution of the C-terminal region on chaperone activity of Hsp70, 3rd Author, 2023
- Methylene blue accelerates liquid-to-gel transition of Tau condensates: impacts on functional and pathological roles of Tau, 16th Author, 2023
- Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, 3rd Author, 2023
- 蛋白质错误折叠相关疾病的多肽药物研究进展, 11th Author, 2022
- Peptide-based Strategies for Treatment of Protein Misfolding Diseases, 11th Author, 2022
- Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation, 11th Author, 2022
- Hsp70 in Redox Homeostasis, 3rd Author, 2022
- Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis, 11th Author, 2022
- Single Molecule Characterization of Amyloid Oligomers, 11th Author, 2021
- PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, 3rd Author, 2021
- Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation, 11th Author, 2021
- Studying protein folding in health and disease using biophysical approaches, Not mentioned, 2021
- S -Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, 9th Author, 2020
- Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis, 11th Author, 2020
- Kinetic diversity of amyloid oligomers, 5th Author, 2020
- Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, 1st Author, 2020
- Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils, 11th Author, 2020
- Protein Microgels from Amyloid Fibril Networks, 3rd Author, 2019
- Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2, 11th Author, 2018
- The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast, 5th Author, 2018
- Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling, 7th Author, 2018
- A co-expression strategy to achieve labeling of individual subunits within a dimeric protein for single molecule analysis, 11th Author, 2017
- Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response, 3rd Author, 2016
- Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry, 4th Author, 2015
- Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2, 2nd Author, 2013
