Professor | 吴思 | 数字化转型顾问

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Name	吴思
Contact Information	wusi@moon.ibp.ac.cn
Language ability	中文, 英语
Province	北京

Upload Avatar (500 x 500)

Name

吴思

Contact Information

wusi@moon.ibp.ac.cn

Language ability

中文, 英语

Province

北京

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2005-09--2011-01 博士: 北京大学 2001-09--2005-07 学士: 南开大学
Work Experience	2023-01~现在 - 中国科学院生物物理研究所 - 研究员 2014-01~2022-12 - 中国科学院生物物理研究所 - 副研究员 2011-03~2013-12 - 中国科学院生物物理研究所 - 助理研究员

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2005-09--2011-01 博士: 北京大学
2001-09--2005-07 学士: 南开大学

Work Experience

2023-01~现在 - 中国科学院生物物理研究所 - 研究员
2014-01~2022-12 - 中国科学院生物物理研究所 - 副研究员
2011-03~2013-12 - 中国科学院生物物理研究所 - 助理研究员

Areas of Focus	单分子生物物理学
Publications	Reversible Redox-Dependent Conformational Switch of the C-Terminal alpha-Helical Lid of Human Hsp70 Observed by In-Cell NMR, 第4作者, 2023 Effect of evolution of the C-terminal region on chaperone activity of Hsp70, 第3作者, 2023 Methylene blue accelerates liquid-to-gel transition of Tau condensates: impacts on functional and pathological roles of Tau, 第16作者, 2023 Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, 第3作者, 2023 蛋白质错误折叠相关疾病的多肽药物研究进展, 第11作者, 2022 Peptide-based Strategies for Treatment of Protein Misfolding Diseases, 第11作者, 2022 Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation, 第11作者, 2022 Hsp70 in Redox Homeostasis, 第3作者, 2022 Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis, 第11作者, 2022 Single Molecule Characterization of Amyloid Oligomers, 第11作者, 2021 PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, 第3作者, 2021 Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation, 第11作者, 2021 Studying protein folding in health and disease using biophysical approaches, 未提及, 2021 S -Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, 第9作者, 2020 Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis, 第11作者, 2020 Kinetic diversity of amyloid oligomers, 第5作者, 2020 Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, 第1作者, 2020 Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils, 第11作者, 2020 Protein Microgels from Amyloid Fibril Networks, 第3作者, 2019 Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2, 第11作者, 2018 The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast, 第5作者, 2018 Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling, 第7作者, 2018 A co-expression strategy to achieve labeling of individual subunits within a dimeric protein for single molecule analysis, 第11作者, 2017 Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response, 第3作者, 2016 Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry, 第4作者, 2015 Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2, 第2作者, 2013

Areas of Focus

单分子生物物理学

Publications

Reversible Redox-Dependent Conformational Switch of the C-Terminal alpha-Helical Lid of Human Hsp70 Observed by In-Cell NMR, 第4作者, 2023
Effect of evolution of the C-terminal region on chaperone activity of Hsp70, 第3作者, 2023
Methylene blue accelerates liquid-to-gel transition of Tau condensates: impacts on functional and pathological roles of Tau, 第16作者, 2023
Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, 第3作者, 2023
蛋白质错误折叠相关疾病的多肽药物研究进展, 第11作者, 2022
Peptide-based Strategies for Treatment of Protein Misfolding Diseases, 第11作者, 2022
Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation, 第11作者, 2022
Hsp70 in Redox Homeostasis, 第3作者, 2022
Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis, 第11作者, 2022
Single Molecule Characterization of Amyloid Oligomers, 第11作者, 2021
PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, 第3作者, 2021
Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation, 第11作者, 2021
Studying protein folding in health and disease using biophysical approaches, 未提及, 2021
S -Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, 第9作者, 2020
Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis, 第11作者, 2020
Kinetic diversity of amyloid oligomers, 第5作者, 2020
Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, 第1作者, 2020
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils, 第11作者, 2020
Protein Microgels from Amyloid Fibril Networks, 第3作者, 2019
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2, 第11作者, 2018
The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast, 第5作者, 2018
Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling, 第7作者, 2018
A co-expression strategy to achieve labeling of individual subunits within a dimeric protein for single molecule analysis, 第11作者, 2017
Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response, 第3作者, 2016
Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry, 第4作者, 2015
Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2, 第2作者, 2013

单分子生物物理学 Hsp70 蛋白质错误折叠淀粉样蛋白 Tau 核磁共振伴侣蛋白蛋白质折叠氧化还原稳态

黄成栋 - 中国科学技术大学

Area of Focus
核磁共振 | 生物分子 | 结构 | 功能 | 机理 | 生物物理 | 蛋白质 | 复合物 | 伴侣蛋白 | 囊泡生成

王申 - 华中科技大学

娄继忠 - 中国科学院大学

Area of Focus
肿瘤 | 免疫 | 调控 | T细胞 | 力免疫学 | 信号传导 | 单分子 | 生物物理学 | 分子动力学 | 模拟

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