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吴思
Life Science
中国科学院大学
北京
Language: 中文, 英语
单分子
生物物理学
Hsp70
蛋白质错误折叠
淀粉样蛋白
Tau
核磁共振
伴侣蛋白
蛋白质折叠
氧化还原稳态
Areas of Focus
- 单分子生物物理学
Work Experience
- 2023-01~现在 - 中国科学院生物物理研究所 - 研究员
- 2014-01~2022-12 - 中国科学院生物物理研究所 - 副研究员
- 2011-03~2013-12 - 中国科学院生物物理研究所 - 助理研究员
Academic Background & Achievements
- 2005-09--2011-01 博士: 北京大学
- 2001-09--2005-07 学士: 南开大学
Publications
- Reversible Redox-Dependent Conformational Switch of the C-Terminal alpha-Helical Lid of Human Hsp70 Observed by In-Cell NMR, 第4作者, 2023
- Effect of evolution of the C-terminal region on chaperone activity of Hsp70, 第3作者, 2023
- Methylene blue accelerates liquid-to-gel transition of Tau condensates: impacts on functional and pathological roles of Tau, 第16作者, 2023
- Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, 第3作者, 2023
- 蛋白质错误折叠相关疾病的多肽药物研究进展, 第11作者, 2022
- Peptide-based Strategies for Treatment of Protein Misfolding Diseases, 第11作者, 2022
- Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation, 第11作者, 2022
- Hsp70 in Redox Homeostasis, 第3作者, 2022
- Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis, 第11作者, 2022
- Single Molecule Characterization of Amyloid Oligomers, 第11作者, 2021
- PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, 第3作者, 2021
- Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation, 第11作者, 2021
- Studying protein folding in health and disease using biophysical approaches, 未提及, 2021
- S -Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, 第9作者, 2020
- Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis, 第11作者, 2020
- Kinetic diversity of amyloid oligomers, 第5作者, 2020
- Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, 第1作者, 2020
- Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils, 第11作者, 2020
- Protein Microgels from Amyloid Fibril Networks, 第3作者, 2019
- Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2, 第11作者, 2018
- The C-terminal GGAP motif of Hsp70 mediates substrate recognition and stress response in yeast, 第5作者, 2018
- Revealing the Mechanism of Amyloid Fibril Formation by Combined Single Molecule FRET and Kinetic Modeling, 第7作者, 2018
- A co-expression strategy to achieve labeling of individual subunits within a dimeric protein for single molecule analysis, 第11作者, 2017
- Glutathionylation of the Bacterial Hsp70 Chaperone DnaK Provides a Link between Oxidative Stress and the Heat Shock Response, 第3作者, 2016
- Enzymatically Active Microgels from Self-Assembling Protein Nanofibrils for Microflow Chemistry, 第4作者, 2015
- Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2, 第2作者, 2013
