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Rui Bi
Life Science
University of Chinese Academy of Sciences
Yunnan
Language: Chinese, English
Alzheimer'S Disease
Neuropsychiatric Disorders
Genetic Basis
Pathogenesis
Transgenic Models
Tree Shrew
Mitochondria
Neurodegenerative Diseases
Genetic Susceptibility
Disease Mechanisms
Areas of Focus
- Genetic basis and pathogenesis of neuropsychiatric disorders such as Alzheimer's disease
- Establishment of transgenic tree shrew disease models
- Mitochondria and neurodegenerative diseases
Work Experience
- 2018-01~Present - Kunming Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
- 2015-01~2017-12 - Kunming Institute of Zoology, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2009-09--2014-12 Ph.D.: University of Chinese Academy of Sciences
- 2005-09--2009-06 Bachelor's: Yunnan University
- 2014: Ph.D. in Science from University of Chinese Academy of Sciences
Publications
- Functional genomics identify causal variant underlying the protective CTSH locus for Alzheimer's disease., Li, Yu, Xu, Min, Xiang, BoLin, Li, Xiao, Zhang, DengFeng, Zhao, Hui, Bi, Rui, Yao, YongGang., 2023
- Convergent transcriptomic and genomic evidence supporting a dysregulation of CXCL16 and CCL5 in Alzheimer’s disease., Xiao Li, Deng-Feng Zhang, Rui Bi, Li-Wen Tan, Xiaogang Chen, Min Xu, Yong-Gang Yao., 2023
- Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing., Rui Bi, Yu Li, Min Xu, Quanzhen Zheng, DengFeng Zhang, Xiao Li, Guolan Ma, Bolin Xiang, Xiaojia Zhu, Hui Zhao, Xingxu Huang, Ping Zheng, YongGang Yao., 2022
- Exploring the Genetic Association of the ABAT Gene with Alzheimer's Disease., Zheng, Quanzhen, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, LiWen, Lu, YaPing, Yao, YongGang., 2021
- Tupaia OASL1 Promotes Cellular Antiviral Immune Responses by Recruiting MDA5 to MAVS., Yao, YuLin, Yu, Dandan, Xu, Ling, Gu, Tianle, Li, Yu, Zheng, Xiao, Bi, Rui, Yao, YongGang., 2020
- Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci., Wu, Yong, Bi, Rui, Zeng, Chunhua, Ma, Changguo, Sun, Chunli, Li, Jingzheng, Xiao, Xiao, Li, Ming, Zhang, DengFeng, Zheng, Ping, Sheng, Nengyin, Luo, XiongJian, Yao, YongGang., 2019
- Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease., Wang, Guihong, Zhang, DengFeng, Jiang, HongYan, Fan, Yu, Ma, Lingyan, Shen, Zonglin, Bi, Rui, Xu, Min, Tan, Liwen, Shan, Baoci, Yao, YongGang, Feng, Tao., 2019
- Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese., Zhang, DengFeng, Fan, Yu, Xu, Min, Wang, Guihong, Wang, Dong, Li, Jin, Kong, LiLi, Zhou, Hejiang, Luo, Rongcan, Bi, Rui, Wu, Yong, Li, GuoDong, Li, Ming, Luo, XiongJian, Jiang, HongYan, Tan, Liwen, Zhong, Chunjiu, Fang, Yiru, Zhang, Chen, Sheng, Nengyin, Jiang, Tianzi, Yao, YongGang., 2019
- Genetic Analyses of Alzheimer's Disease in China: Achievements and Perspectives., Zhang, DengFeng, Xu, Min, Bi, Rui, Yao, YongGang., 2019
- A systematic integrated analysis of brain expression profiles reveals YAP1 and other prioritized hub genes as important upstream regulators in Alzheimer's disease., Xu, Min, Zhang, DengFeng, Luo, Rongcan, Wu, Yong, Zhou, Hejiang, Kong, LiLi, Bi, Rui, Yao, YongGang., 2018
- Genetic association of the cytochrome c oxidase-related genes with Alzheimer's disease in Han Chinese., Bi, Rui, Zhang, Wen, Zhang, DengFeng, Xu, Min, Fan, Yu, Hu, QiuXiang, Jiang, HongYan, Tan, Liwen, Li, Tao, Fang, Yiru, Zhang, Chen, Yao, YongGang., 2018
- Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese., DengFeng Zhang, Dong Wang, YongGang Yao, Mahadev Malhi, Rui Bi, Yong Wu, Min Xu, XiuFeng Yu, Heng Long, YuYe Li., 2018
- Does the Genetic Feature of the Chinese Tree Shrew (Tupaia belangeri chinensis) Support Its Potential as a Viable Model for Alzheimer’s Disease Research?., Yu Fan, Rongcan Luo, LingYan Su, Qun Xiang, Dandan Yu, Ling Xu, JiaQi Chen, Rui Bi, DongDong Wu, Ping Zheng, YongGang Yao., 2018
- A pleiotropic effect of the APOE gene: association of APOE polymorphisms with multibacillary leprosy in Han Chinese from Southwest China., Wang, D, Zhang, D F, Li, G D, Bi, R, Fan, Y, Wu, Y, Yu, X F, Long, H, Li, Y Y, Yao, Y G., 2018
- The Arc Gene Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese., Bi, Rui, Kong, LiLi, Xu, Min, Li, GuoDong, Zhang, DengFeng, Li, Tao, Fang, Yiru, Zhang, Chen, Zhang, Buchang, Yao, YongGang., 2018
- Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese., Wang, Dong, Fan, Yu, Malhi, Mahadev, Bi, Rui, Wu, Yong, Xu, Min, Yu, XiuFeng, Long, Heng, Li, YuYe, Zhang, DengFeng, Yao, YongGang., 2018
- mtDNA sequence diversity of Hazara ethnic group from Pakistan., Rakha, Allah, Fatima, Peng, MinSheng, Adan, Atif, Bi, Rui, Yasmin, Memona, Yao, YongGang., 2017
- Leber Hereditary Optic Neuropathy: A Mitochondrial Disease Unique in Many Ways., Bi R, Logan I, Yao YG., 2017
- The OPA1 Gene Mutations Are Frequent in Han Chinese Patients with Suspected Optic Neuropathy., Zhang, AMei, Bi, Rui, Hu, QiuXiang, Fan, Yu, Zhang, Qingjiong, Yao, YongGang., 2017
- Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer’s Disease in Han Chinese., Xiang Qun, Bi Rui, Xu Min, Zhang DengFeng, Tan Liwen, Zhang Chen, Fang Yiru, Yao YongGang., 2017
- Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring., Li, ChaoHui, Yan, LanZhen, Ban, WenZan, Tu, Qiu, Wu, Yong, Wang, Lin, Bi, Rui, Ji, Shuang, Ma, YuHua, Nie, WenHui, Lv, LongBao, Yao, YongGang, Zhao, XuDong, Zheng, Ping., 2017
- Female-specific effect of the BDNF gene on Alzheimer's disease., Li, GuoDong, Bi, Rui, Zhang, DengFeng, Xu, Min, Luo, Rongcan, Wang, Dong, Fang, Yiru, Li, Tao, Zhang, Chen, Yao, YongGang., 2017
- Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer's Disease in Han Chinese., Xiang, Qun, Bi, Rui, Xu, Min, Zhang, DengFeng, Tan, Liwen, Zhang, Chen, Fang, Yiru, Yao, YongGang., 2017
- The mtDNA replication-related genes TFAM and POLG are associated with leprosy in Han Chinese from Southwest China., Wang Dong, Li GuoDong, Fan Yu, Zhang DengFeng, Bi Rui, Yu XiuFeng, Long Heng, Li YuYe, Yao YongGang., 2017
- mtDNA Heteroplasmy in Monozygotic Twins Discordant for Schizophrenia., Li, Hong, Bi, Rui, Fan, Yu, Wu, Yong, Tang, Yanqing, Li, Zongchang, He, Ying, Zhou, Jun, Tang, Jinsong, Chen, Xiaogang, Yao, YongGang., 2017
- Validating GWAS-Identified Risk L
Awards
- 2015: Yunnan Provincial Science and Technology Award, Second Prize (Natural Science Award); Project: Genetic Susceptibility Analysis of Leber Hereditary Optic Neuropathy; Awardees: Yonggang Yao, Amei Zhang, Dandan Yu, Rui Bi.
- 2015: Kunming Science and Technology Progress Award, Second Prize; Project: Clinical Application of Mitochondrial DNA Mutations on Maternal Inherited Hypertension; Awardees: Hao Guo, Dandan Yu, Yong Yuan, Li Guo, Rui Bi, Qing Tian, Wei Wang, Yuemei Feng, Guochang Xiong.
- 2013: Model Student
- 2012: National Scholarship, University of Chinese Academy of Sciences
- 2012: Zhu Li Yuehua Excellent Doctoral Student Award
- 2011: President's Award, Chinese Academy of Sciences, Excellence Award
- 2010: Di'ao Scholarship, Chinese Academy of Sciences, Second Prize
