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Chang Hong
Life Science
University of Chinese Academy of Sciences
Yunnan
Language: Chinese, English
Genomics
Psychiatric Disorders
Depression
Schizophrenia
Bipolar Disorder
Gene Expression
Neurodevelopment
Risk Variants
Molecular Mechanisms
Functional Analysis
Areas of Focus
- Functional Genomics of Psychiatric Disorders
Work Experience
- 2022-01~2022-06 - Kunming Institute of Zoology - Researcher
- 2017-01~2021-12 - Kunming Institute of Zoology - Associate Researcher
- 2016-07~2017-01 - Kunming Institute of Zoology - Assistant Researcher
- 2014-01~2016-06 - Mitchell Cancer Institute, University of South Alabama - Postdoctoral Researcher
- 2012-07~2013-09 - Kunming Institute of Zoology - Assistant Researcher
- 2011-07~2012-06 - Kunming Institute of Zoology - Research Intern
Academic Background & Achievements
- 2008-09--2011-06 PhD in Science: University of Chinese Academy of Sciences
- 2005-09--2008-06 MSc in Science: Yunnan University
- 2001-09--2005-06 BSc in Science: Yunnan University
Publications
- Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice, Chang Hong, 2023
- Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function, Chang Hong, 2023
- Functional genomic analysis delineates regulatory mechanisms of GWAS-identified bipolar disorder risk variants, Chang Hong, 2022
- A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MT(d2d3) and Mushroom Dendritic Spine Density, Chang Hong, 2021
- Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder, Chang Hong, 2021
- Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus, Chang Hong, 2021
- Regulation of TRANK1 by GSK-3 in the brain: unexpected interactions, Chang Hong, 2021
- Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder, Chang Hong, 2019
- Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder, Chang Hong, 2019
- The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders, Chang Hong, 2018
- Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population, Chang Hong, 2018
- Rare and common variants at 16p11.2 are associated with schizophrenia, Chang Hong, 2017
- The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions, Chang Hong, 2017
- Evaluation of European Schizophrenia GWAS Loci in Asian Populations via Comprehensive Meta-Analyses, Chang Hong, 2017
- Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1, Chang Hong, 2017
- Replication analyses of four chromosomal deletions with schizophrenia via independent large-scale meta-analyses, Chang Hong, 2016
- CRISPR/cas9, a novel genomic tool to knock down microRNA in vitro and in vivo, Chang Hong, 2016
- Expression and distribution of symplekin regulates the assembly and function of the epithelial tight junction, Chang Hong, 2012
- Methylation of tumor associated genes in tissue and plasma samples from liver disease patients, Chang Hong, 2008
