Professor | Yu Chen | Asia Growth Partners

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Name	Yu Chen
Contact Information	y.chen3@siat.ac.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Yu Chen

Contact Information

y.chen3@siat.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2012-09 to 2018-06 PhD: East China University of Science and Technology 2008-09 to 2012-06 Bachelor's Degree: Huazhong Agricultural University
Work Experience	2024-01 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher 2023-02 to 2024-01 - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Associate Researcher 2018-02 to 2022-12 - Chalmers University of Technology - Postdoctoral Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2012-09 to 2018-06 PhD: East China University of Science and Technology
2008-09 to 2012-06 Bachelor's Degree: Huazhong Agricultural University

Work Experience

2024-01 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher
2023-02 to 2024-01 - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Associate Researcher
2018-02 to 2022-12 - Chalmers University of Technology - Postdoctoral Researcher

Areas of Focus	Synthetic Biology Systems Biology Metabolic Engineering
Publications	Single-cell omics analysis with genome-scale metabolic modeling, Yu Chen, 2024 Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast, Yu Chen, 2023 Engineering yeast mitochondrial metabolism for 3-hydroxypropionate production, Yu Chen, 2023 Engineering yeast for high-level production of diterpenoid sclareol, Yu Chen, 2023 Deep learning-based k(cat) prediction enables improved enzyme-constrained model reconstruction, Yu Chen, 2022 Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast (vol 18, pg 520, 2022), Yu Chen, 2022 Yeast has evolved to minimize protein resource cost for synthesizing amino acids, Yu Chen, 2022 Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints, Yu Chen, 2022 Genome-scale modeling of yeast metabolism: retrospectives and perspectives, Yu Chen, 2022 GotEnzymes: an extensive database of enzyme parameter predictions, Yu Chen, 2022 Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation, Yu Chen, 2022 Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments, Yu Chen, 2021 Mathematical modelling of proteome constraints within metabolism, Yu Chen, 2021 Yeast optimizes metal utilization based on metabolic network and enzyme kinetics, Yu Chen, 2021 Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection, Yu Chen, 2021 Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues, Yu Chen, 2021 In vitro turnover numbers do not reflect in vivo activities of yeast enzymes, Yu Chen, 2021 Genome-scale modeling for Bacillus coagulans to understand the metabolic characteristics, Yu Chen, 2020 Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism, Yu Chen, 2020 Rewiring carbon metabolism in yeast for high level production of aromatic chemicals, Yu Chen, 2019 Energy metabolism controls phenotypes by protein efficiency and allocation, Yu Chen, 2019 Systematic inference of functional phosphorylation events in yeast metabolism, Yu Chen, 2017 Flux control through protein phosphorylation in yeast, Yu Chen, 2016 Effect of pH, glucoamylase, pullulanase and invertase addition on the degradation of residual sugar in L-lactic acid fermentation by Bacillus coagulans HL-5 with corn flour hydrolysate, Yu Chen, 2016 Systematic development and optimization of chemically defined medium supporting high cell density growth of Bacillus coagulans, Yu Chen, 2016

Areas of Focus

Synthetic Biology
Systems Biology
Metabolic Engineering

Publications

Single-cell omics analysis with genome-scale metabolic modeling, Yu Chen, 2024
Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast, Yu Chen, 2023
Engineering yeast mitochondrial metabolism for 3-hydroxypropionate production, Yu Chen, 2023
Engineering yeast for high-level production of diterpenoid sclareol, Yu Chen, 2023
Deep learning-based k(cat) prediction enables improved enzyme-constrained model reconstruction, Yu Chen, 2022
Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast (vol 18, pg 520, 2022), Yu Chen, 2022
Yeast has evolved to minimize protein resource cost for synthesizing amino acids, Yu Chen, 2022
Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints, Yu Chen, 2022
Genome-scale modeling of yeast metabolism: retrospectives and perspectives, Yu Chen, 2022
GotEnzymes: an extensive database of enzyme parameter predictions, Yu Chen, 2022
Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation, Yu Chen, 2022
Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments, Yu Chen, 2021
Mathematical modelling of proteome constraints within metabolism, Yu Chen, 2021
Yeast optimizes metal utilization based on metabolic network and enzyme kinetics, Yu Chen, 2021
Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection, Yu Chen, 2021
Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues, Yu Chen, 2021
In vitro turnover numbers do not reflect in vivo activities of yeast enzymes, Yu Chen, 2021
Genome-scale modeling for Bacillus coagulans to understand the metabolic characteristics, Yu Chen, 2020
Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism, Yu Chen, 2020
Rewiring carbon metabolism in yeast for high level production of aromatic chemicals, Yu Chen, 2019
Energy metabolism controls phenotypes by protein efficiency and allocation, Yu Chen, 2019
Systematic inference of functional phosphorylation events in yeast metabolism, Yu Chen, 2017
Flux control through protein phosphorylation in yeast, Yu Chen, 2016
Effect of pH, glucoamylase, pullulanase and invertase addition on the degradation of residual sugar in L-lactic acid fermentation by Bacillus coagulans HL-5 with corn flour hydrolysate, Yu Chen, 2016
Systematic development and optimization of chemically defined medium supporting high cell density growth of Bacillus coagulans, Yu Chen, 2016

Synthetic Biology: Genetic Circuits Metabolic Pathways Bioengineering Gene Synthesis Protein Design Cellular Systems Metabolic Networks Biosensors Biomanufacturing Genome Editing Systems Biology: Computational Modeling Biological Networks Data Integration Omics Technologies Dynamic Systems Regulatory Networks Pathway Analysis Cellular Behavior System Dynamics Bioinformatics Metabolic Engineering: Metabolic Pathways Enzyme Engineering Flux Analysis Bioproduction Metabolic Flux Pathway Optimization Synthetic Pathways Metabolic Control Biocatalysis

Ming Jiang - Shanghai Jiao Tong University

Ming Jiang - Shanghai Jiao Tong University

Guangyu Yang - Shanghai Jiao Tong University

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