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Yu Chen
Life Science
University of Chinese Academy of Sciences
Guangdong
Language: Chinese, English
Synthetic Biology: Genetic Circuits
Metabolic Pathways
Bioengineering
Gene Synthesis
Protein Design
Cellular Systems
Metabolic Networks
Biosensors
Biomanufacturing
Genome Editing
Systems Biology: Computational Modeling
Biological Networks
Data Integration
Omics Technologies
Dynamic Systems
Regulatory Networks
Pathway Analysis
Cellular Behavior
System Dynamics
Bioinformatics
Metabolic Engineering: Metabolic Pathways
Enzyme Engineering
Flux Analysis
Bioproduction
Metabolic Flux
Pathway Optimization
Synthetic Pathways
Metabolic Control
Biocatalysis
Areas of Focus
- Synthetic Biology
- Systems Biology
- Metabolic Engineering
Work Experience
- 2024-01 to Present - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Researcher
- 2023-02 to 2024-01 - Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences - Associate Researcher
- 2018-02 to 2022-12 - Chalmers University of Technology - Postdoctoral Researcher
Academic Background & Achievements
- 2012-09 to 2018-06 PhD: East China University of Science and Technology
- 2008-09 to 2012-06 Bachelor's Degree: Huazhong Agricultural University
Publications
- Single-cell omics analysis with genome-scale metabolic modeling, Yu Chen, 2024
- Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast, Yu Chen, 2023
- Engineering yeast mitochondrial metabolism for 3-hydroxypropionate production, Yu Chen, 2023
- Engineering yeast for high-level production of diterpenoid sclareol, Yu Chen, 2023
- Deep learning-based k(cat) prediction enables improved enzyme-constrained model reconstruction, Yu Chen, 2022
- Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast (vol 18, pg 520, 2022), Yu Chen, 2022
- Yeast has evolved to minimize protein resource cost for synthesizing amino acids, Yu Chen, 2022
- Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints, Yu Chen, 2022
- Genome-scale modeling of yeast metabolism: retrospectives and perspectives, Yu Chen, 2022
- GotEnzymes: an extensive database of enzyme parameter predictions, Yu Chen, 2022
- Proteome allocations change linearly with the specific growth rate of Saccharomyces cerevisiae under glucose limitation, Yu Chen, 2022
- Proteome constraints reveal targets for improving microbial fitness in nutrient-rich environments, Yu Chen, 2021
- Mathematical modelling of proteome constraints within metabolism, Yu Chen, 2021
- Yeast optimizes metal utilization based on metabolic network and enzyme kinetics, Yu Chen, 2021
- Yeast metabolic innovations emerged via expanded metabolic network and gene positive selection, Yu Chen, 2021
- Engineering yeast metabolism for the discovery and production of polyamines and polyamine analogues, Yu Chen, 2021
- In vitro turnover numbers do not reflect in vivo activities of yeast enzymes, Yu Chen, 2021
- Genome-scale modeling for Bacillus coagulans to understand the metabolic characteristics, Yu Chen, 2020
- Combining mechanistic and machine learning models for predictive engineering and optimization of tryptophan metabolism, Yu Chen, 2020
- Rewiring carbon metabolism in yeast for high level production of aromatic chemicals, Yu Chen, 2019
- Energy metabolism controls phenotypes by protein efficiency and allocation, Yu Chen, 2019
- Systematic inference of functional phosphorylation events in yeast metabolism, Yu Chen, 2017
- Flux control through protein phosphorylation in yeast, Yu Chen, 2016
- Effect of pH, glucoamylase, pullulanase and invertase addition on the degradation of residual sugar in L-lactic acid fermentation by Bacillus coagulans HL-5 with corn flour hydrolysate, Yu Chen, 2016
- Systematic development and optimization of chemically defined medium supporting high cell density growth of Bacillus coagulans, Yu Chen, 2016
