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Dimitri Lavillette
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: English, French, Chinese
Dengue
Chikungunya
Zika
Pathogenesis
Cellular Mechanisms
Vaccines
Specific Drugs
Co-Infection
Virus-Virus Interaction
Emerging Viruses
Areas of Focus
- Cellular mechanisms of Dengue, Chikungunya, and Zika virus pathogenesis
- Development of vaccines and specific drugs for Dengue, Chikungunya, and Zika viruses
- Research on co-infection and virus-virus interaction of emerging viruses
Work Experience
- 2014-11 to Present - Institut Pasteur of Shanghai, CAS - Principal Investigator
- 2012-11 to 2014-11 - CNRS, France - Tenure Staff Scientist Position (CNRS CR1)
- 2011-01 to 2011-12 - Glycobiology Institute, Oxford University - Visiting Scientist
- 2003-05 to 2012-11 - INSERM U758, ENS de Lyon, France - Tenure Staff Scientist Position (CNRS CR1)
- 2001-02 to 2003-05 - OHSU, Portland, USA - Post Doc
- 2000-11 to 2001-02 - Mayo Clinic, Minnesota, USA - Visiting Scientist
Academic Background & Achievements
- 2009-02 to 2009-12 Habilitation to Direct Research (HDR): ENS de Lyon
- 1997-10 to 2000-11 PhD: INSERM, ENS de Lyon
- 1994-09 to 1997-10 Master: Lyon University
- 1991-09 to 1994-09 Bachelor: Dijon University
Publications
- A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism., Dimitri Lavillette, 2018
- Chronic infection of mosquito by Chikungunya virus increases its susceptibility to Zika, Dengue and Yellow fever viruses during coinfection., Dimitri Lavillette, 2017
- Specialization of hepatitis C virus envelope glycoproteins for B-lymphocytes in chronically infected patients., Dimitri Lavillette, 2016
- New insights into the understanding of hepatitis C virus entry and cell-to-cell transmission by using the ionophore Monensin A, Dimitri Lavillette, 2015
- The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions., Dimitri Lavillette, 2015
- Low cross-neutralization of hepatitis C correlates with liver disease in immunocompromized patients, Dimitri Lavillette, 2015
- The mechanism of HCV entry into host cells., Dimitri Lavillette, 2015
- A Critical Interaction Between E1 and E2 Glycoproteins Determines Binding and Fusion Properties of Hepatitis C Virus During Cell Entry, Dimitri Lavillette, 2014
- Baboon envelope pseudotyped lentiviral vectors outperform VSV-G pseudotyped lentiviral vectors for gene transfer into cytokine-stimulated and resting hematopoietic stem cells, Dimitri Lavillette, 2014
- The Expression of the Hepatocyte SLAMF3 (CD229) Receptor Enhances the Hepatitis C Virus Infection, Dimitri Lavillette, 2014
- Up-Regulation of the ATP-Binding Cassette Transporter A1 Inhibits Hepatitis C Virus Infection., Dimitri Lavillette, 2014
- Virus-like particle vaccine induces cross-protection against human metapneumovirus infections in mice., Dimitri Lavillette, 2013
- The antimalarial ferroquine is an inhibitor of hepatitis C virus, Dimitri Lavillette, 2013
- Characterization of hepatitis C virus particle sub-populations reveals multiple usage of the scavenger receptor BI for entry steps, Dimitri Lavillette, 2012
- Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle., Dimitri Lavillette, 2012
- Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2., Dimitri Lavillette, 2012
- A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques., Dimitri Lavillette, 2011
- EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy., Dimitri Lavillette, 2011
- Mechanism of Inhibition of Enveloped Virus Membrane Fusion by the Antiviral Drug Arbidol., Dimitri Lavillette, 2011
- Cell Entry of Enveloped Viruses, Dimitri Lavillette, 2011
- Kinases required in hepatitis C virus entry and replication highlighted by small interference RNA screening, Dimitri Lavillette, 2009
- Characterization of fusion determinants points to the involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus, Dimitri Lavillette, 2007
- Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection, Dimitri Lavillette, 2005
- Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus, Dimitri Lavillette, 2005
Awards
- Shanghai '****' Talent Introduction Program, First Prize, Provincial Level, 2015
- Chinese Academy of Sciences 2015 Second Batch '****' A Category, Institute Level, 2015
