Professor | Dimitri Lavillette | 数字化转型顾问

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Name	Dimitri Lavillette
Contact Information	dlaville@ips.ac.cn
Language ability	英语, 法语, 中文
Province	上海

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Name

Dimitri Lavillette

Contact Information

dlaville@ips.ac.cn

Language ability

英语, 法语, 中文

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	2009-02 到 2009-12 研究指导资格 (HDR): 里昂高等师范学院 1997-10 到 2000-11 博士: 法国国家医学与健康科学研究院, 里昂高等师范学院 1994-09 到 1997-10 硕士: 里昂大学 1991-09 到 1994-09 学士: 第戎大学
Work Experience	2014-11 至今 - 中科院上海巴斯德研究所 - 研究员 2012-11 到 2014-11 - 法国国家科学研究院 - 副教授 2011-01 到 2011-12 - 牛津大学Glycobiology研究所 - 访问学者 2003-05 到 2012-11 - 法国国家医学与健康研究院, 里昂高等师范学院 - 副教授 2001-02 到 2003-05 - 美国俄勒冈卫生科学大学 - 博士后 2000-11 到 2001-02 - 美国Mayo医学中心 - 项目访问学者
Awards	上海“**”引进人才, 一等奖, 省级, 2015 中国科学院2015年度第二批“**”A类, 院级, 2015

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

2009-02 到 2009-12 研究指导资格 (HDR): 里昂高等师范学院
1997-10 到 2000-11 博士: 法国国家医学与健康科学研究院, 里昂高等师范学院
1994-09 到 1997-10 硕士: 里昂大学
1991-09 到 1994-09 学士: 第戎大学

Work Experience

2014-11 至今 - 中科院上海巴斯德研究所 - 研究员
2012-11 到 2014-11 - 法国国家科学研究院 - 副教授
2011-01 到 2011-12 - 牛津大学Glycobiology研究所 - 访问学者
2003-05 到 2012-11 - 法国国家医学与健康研究院, 里昂高等师范学院 - 副教授
2001-02 到 2003-05 - 美国俄勒冈卫生科学大学 - 博士后
2000-11 到 2001-02 - 美国Mayo医学中心 - 项目访问学者

Awards

上海“****”引进人才, 一等奖, 省级, 2015
中国科学院2015年度第二批“****”A类, 院级, 2015

Areas of Focus	登革热、基孔肯雅病毒和寨卡病毒致病的细胞机理登革热、基孔肯雅病毒和寨卡病毒疫苗和特效药的开发其他新发病毒Co-infection和virus-virus interaction相关研究
Publications	A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism., Dimitri Lavillette, 2018 Chronic infection of mosquito by Chikungunya virus increases its susceptibility to Zika, Dengue and Yellow fever viruses during coinfection., Dimitri Lavillette, 2017 Specialization of hepatitis C virus envelope glycoproteins for B-lymphocytes in chronically infected patients., Dimitri Lavillette, 2016 New insights into the understanding of hepatitis C virus entry and cell-to-cell transmission by using the ionophore Monensin A, Dimitri Lavillette, 2015 The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions., Dimitri Lavillette, 2015 Low cross-neutralization of hepatitis C correlates with liver disease in immunocompromized patients, Dimitri Lavillette, 2015 The mechanism of HCV entry into host cells., Dimitri Lavillette, 2015 A Critical Interaction Between E1 and E2 Glycoproteins Determines Binding and Fusion Properties of Hepatitis C Virus During Cell Entry, Dimitri Lavillette, 2014 Baboon envelope pseudotyped lentiviral vectors outperform VSV-G pseudotyped lentiviral vectors for gene transfer into cytokine-stimulated and resting hematopoietic stem cells, Dimitri Lavillette, 2014 The Expression of the Hepatocyte SLAMF3 (CD229) Receptor Enhances the Hepatitis C Virus Infection, Dimitri Lavillette, 2014 Up-Regulation of the ATP-Binding Cassette Transporter A1 Inhibits Hepatitis C Virus Infection., Dimitri Lavillette, 2014 Virus-like particle vaccine induces cross-protection against human metapneumovirus infections in mice., Dimitri Lavillette, 2013 The antimalarial ferroquine is an inhibitor of hepatitis C virus, Dimitri Lavillette, 2013 Characterization of hepatitis C virus particle sub-populations reveals multiple usage of the scavenger receptor BI for entry steps, Dimitri Lavillette, 2012 Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle., Dimitri Lavillette, 2012 Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2., Dimitri Lavillette, 2012 A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques., Dimitri Lavillette, 2011 EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy., Dimitri Lavillette, 0201

Areas of Focus

登革热、基孔肯雅病毒和寨卡病毒致病的细胞机理
登革热、基孔肯雅病毒和寨卡病毒疫苗和特效药的开发
其他新发病毒Co-infection和virus-virus interaction相关研究

Publications

A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism., Dimitri Lavillette, 2018
Chronic infection of mosquito by Chikungunya virus increases its susceptibility to Zika, Dengue and Yellow fever viruses during coinfection., Dimitri Lavillette, 2017
Specialization of hepatitis C virus envelope glycoproteins for B-lymphocytes in chronically infected patients., Dimitri Lavillette, 2016
New insights into the understanding of hepatitis C virus entry and cell-to-cell transmission by using the ionophore Monensin A, Dimitri Lavillette, 2015
The sheep tetherin paralog oBST2B blocks envelope glycoprotein incorporation into nascent retroviral virions., Dimitri Lavillette, 2015
Low cross-neutralization of hepatitis C correlates with liver disease in immunocompromized patients, Dimitri Lavillette, 2015
The mechanism of HCV entry into host cells., Dimitri Lavillette, 2015
A Critical Interaction Between E1 and E2 Glycoproteins Determines Binding and Fusion Properties of Hepatitis C Virus During Cell Entry, Dimitri Lavillette, 2014
Baboon envelope pseudotyped lentiviral vectors outperform VSV-G pseudotyped lentiviral vectors for gene transfer into cytokine-stimulated and resting hematopoietic stem cells, Dimitri Lavillette, 2014
The Expression of the Hepatocyte SLAMF3 (CD229) Receptor Enhances the Hepatitis C Virus Infection, Dimitri Lavillette, 2014
Up-Regulation of the ATP-Binding Cassette Transporter A1 Inhibits Hepatitis C Virus Infection., Dimitri Lavillette, 2014
Virus-like particle vaccine induces cross-protection against human metapneumovirus infections in mice., Dimitri Lavillette, 2013
The antimalarial ferroquine is an inhibitor of hepatitis C virus, Dimitri Lavillette, 2013
Characterization of hepatitis C virus particle sub-populations reveals multiple usage of the scavenger receptor BI for entry steps, Dimitri Lavillette, 2012
Matrigel-embedded 3D culture of Huh-7 cells as a hepatocyte-like polarized system to study hepatitis C virus cycle., Dimitri Lavillette, 2012
Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2., Dimitri Lavillette, 2012
A Prime-Boost Strategy Using Virus-Like Particles Pseudotyped for HCV Proteins Triggers Broadly Neutralizing Antibodies in Macaques., Dimitri Lavillette, 2011
EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy., Dimitri Lavillette, 0201

登革热基孔肯雅寨卡致病机理细胞机制疫苗特效药共感染病毒-病毒相互作用新发病毒

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