Professor | Yunwu Zhang | Asia Growth Partners

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Name	Yunwu Zhang
Contact Information	yunzhang@xmu.edu.cn
Language ability	Chinese, English
Province	Fujian

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Name

Yunwu Zhang

Contact Information

yunzhang@xmu.edu.cn

Language ability

Chinese, English

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1992-09 to 1996-06 - Bachelor's in Biochemistry: Beijing Normal University 1996-09 to 2001-04 - PhD in Zoology: Kunming Institute of Zoology, Chinese Academy of Sciences Published over 70 research papers in international journals Received multiple awards including the Ministry of Education's New Century Excellent Talents
Work Experience	1998-08 to 2003-01 - Visiting Scholar: Center for Reproduction of Endangered Species, Zoological Society of San Diego, USA 2003-02 to 2003-11 - Postdoctoral Researcher: City of Hope National Medical Center/Beckman Research Center, USA 2003-11 to 2007-04 - Postdoctoral Researcher: Sanford-Burnham Medical Research Institute, USA 2007-05 to Present - Professor/Doctoral Supervisor: Xiamen University
Awards	Ministry of Education's New Century Excellent Talents

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1992-09 to 1996-06 - Bachelor's in Biochemistry: Beijing Normal University
1996-09 to 2001-04 - PhD in Zoology: Kunming Institute of Zoology, Chinese Academy of Sciences
Published over 70 research papers in international journals
Received multiple awards including the Ministry of Education's New Century Excellent Talents

Work Experience

1998-08 to 2003-01 - Visiting Scholar: Center for Reproduction of Endangered Species, Zoological Society of San Diego, USA
2003-02 to 2003-11 - Postdoctoral Researcher: City of Hope National Medical Center/Beckman Research Center, USA
2003-11 to 2007-04 - Postdoctoral Researcher: Sanford-Burnham Medical Research Institute, USA
2007-05 to Present - Professor/Doctoral Supervisor: Xiamen University

Awards

Ministry of Education's New Century Excellent Talents

Areas of Focus	Cellular and molecular pathogenesis of neurodegenerative diseases, especially Alzheimer's disease
Publications	The neuron-specific protein TMEM59L mediates oxidative stress-induced cell death., Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, Liu Y, Gao Y, Niu M, Meng J, Zhang M, Bu G, Xu H, Zhang YW, 2016 Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology., Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW, 2016 SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation., Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW, 2015 RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits., Yan L, Chen Y, Li W, Huang X, Badie H, Jian F, Huang T, Zhao Y, Cohen SN, Li L, Zhang YW, Luo H, Tu S, Xu H, 2016 Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway., Hu J, Lin T, Xu J, Ding R, Wang G, Shen R, Zhang YW, Chen H, 2016 miR-219 protects against seizure in the kainic acid model of epilepsy., Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Bu G, Xu H, Xing H, Zhang YW, Zheng W, 2016 The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation., Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang YW, 2015 The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation., Hu J, Lin T, Gao Y, Xu J, Jiang C, Wang G, Bu G, Xu H, Chen H, Zhang YW, 2015 Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells., Zheng KM, Zhang J, Zhang CL, Zhang YW, Chen XC, 2015 The γ-secretase complex: from structure to function., Zhang X, Li Y, Xu H, Zhang YW, 2014 Trafficking regulation of proteins in Alzheimer’s disease., Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW, 2014 M1 muscarinic acetylcholine receptor in Alzheimer’s disease., Jiang S, Li Y, Zhang C, Zhao Y, Bu G, Xu H, Zhang YW, 2014 APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival., Zhang YW, Chen Y, Liu Y, Zhao Y, Liao FF, Xu H, 2013 Ferritin light chain interacts with PEN-2 and affects γ-secretase activity., Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW, 2013 Appoptosin is a novel proapoptotic protein and mediates cell death in neurodegeneration., Zhang H#, Zhang YW#, Chen Y#, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JDJ, Bu G, Reed JC, Liao FF, Chen YG, Xu H, 2012 Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing., Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang YW, 2012 CutA divalent cation tolerance homolog (E. Coli) (CUTA) regulates β-cleavage of β-amyloid precursor proteins (APP) through interacting with β-site APP cleaving protein 1 (BACE1)., Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW, 2012 The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer’s β-amyloid level and tau phosphorylation., Huang X, Chen Y, Li W-B, Cohen SN, Liao F-F, Li L, Xu H, Zhang YW, 2010 M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation., Jiang S, Wang Y, Ma Q, Zhou A, Zhang X, Zhang YW, 2012 Substrate check of γ-secretase., Zhang YW, Xu H, 2010 A functional mouse retroposed gene Rps23r1 reduces Alzheimer’s β-amyloid levels and tau phosphorylation., Zhang YW, Liu S, Zhang X, Li WB, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P, Liao FF, Li L, Xu H., 2009 Presenilin/γ-secretase-dependent processing of APP regulates EGFR expression., Zhang YW, Wang R, Liu Q, Zhang H, Liao FF, Xu H*, 2007

Areas of Focus

Cellular and molecular pathogenesis of neurodegenerative diseases, especially Alzheimer's disease

Publications

The neuron-specific protein TMEM59L mediates oxidative stress-induced cell death., Zheng Q, Zheng X, Zhang L, Luo H, Qian L, Fu X, Liu Y, Gao Y, Niu M, Meng J, Zhang M, Bu G, Xu H, Zhang YW*, 2016
Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology., Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, Bu G, Fraser PE, Xu H, Zhang YW*, 2016
SNX15 Regulates Cell Surface Recycling of APP and Aβ Generation., Feng T, Niu M, Ji C, Gao Y, Wen J, Bu G, Xu H, Zhang YW*, 2015
RPS23RG1 reduces Aβ oligomer-induced synaptic and cognitive deficits., Yan L, Chen Y, Li W, Huang X, Badie H, Jian F, Huang T, Zhao Y, Cohen SN, Li L, Zhang YW*, Luo H*, Tu S*, Xu H*, 2016
Polyphenols isolated from leaves of Vitis thunbergii var. taiwaniana regulate APP related pathway., Hu J, Lin T, Xu J, Ding R, Wang G, Shen R, Zhang YW*, Chen H*, 2016
miR-219 protects against seizure in the kainic acid model of epilepsy., Zheng H, Tang R, Yao Y, Ji Z, Cao Y, Liu Z, Peng F, Wang W, Can D, Bu G, Xu H, Xing H, Zhang YW*, Zheng W*, 2016
The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation., Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang YW*, 2015
The Resveratrol Trimer Miyabenol C Inhibits β-Secretase Activity and β-Amyloid Generation., Hu J, Lin T, Gao Y, Xu J, Jiang C, Wang G, Bu G, Xu H, Chen H, Zhang YW*, 2015
Curcumin inhibits appoptosin-induced apoptosis via upregulating heme oxygenase-1 expression in SH-SY5Y cells., Zheng KM, Zhang J, Zhang CL, Zhang YW*, Chen XC*, 2015
The γ-secretase complex: from structure to function., Zhang X, Li Y, Xu H, Zhang YW*, 2014
Trafficking regulation of proteins in Alzheimer’s disease., Jiang S, Li Y, Zhang X, Bu G, Xu H, Zhang YW*, 2014
M1 muscarinic acetylcholine receptor in Alzheimer’s disease., Jiang S, Li Y, Zhang C, Zhao Y, Bu G, Xu H, Zhang YW*, 2014
APP regulates NGF receptor trafficking and NGF-mediated neuronal differentiation and survival., Zhang YW*, Chen Y, Liu Y, Zhao Y, Liao FF, Xu H*, 2013
Ferritin light chain interacts with PEN-2 and affects γ-secretase activity., Li X, Liu Y, Zheng Q, Yao G, Cheng P, Bu G, Xu H, Zhang YW*, 2013
Appoptosin is a novel proapoptotic protein and mediates cell death in neurodegeneration., Zhang H#, Zhang YW#, Chen Y#, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JDJ, Bu G, Reed JC, Liao FF, Chen YG, Xu H, 2012
Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing., Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang YW*, 2012
CutA divalent cation tolerance homolog (E. Coli) (CUTA) regulates β-cleavage of β-amyloid precursor proteins (APP) through interacting with β-site APP cleaving protein 1 (BACE1)., Zhao Y, Wang Y, Hu J, Zhang X, Zhang YW*, 2012
The Rps23rg gene family originated through retroposition of the ribosomal protein s23 mRNA and encodes proteins that decrease Alzheimer’s β-amyloid level and tau phosphorylation., Huang X, Chen Y, Li W-B, Cohen SN, Liao F-F, Li L, Xu H, Zhang YW*, 2010
M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation., Jiang S, Wang Y, Ma Q, Zhou A, Zhang X, Zhang YW*, 2012
Substrate check of γ-secretase., Zhang YW, Xu H, 2010
A functional mouse retroposed gene Rps23r1 reduces Alzheimer’s β-amyloid levels and tau phosphorylation., Zhang YW, Liu S, Zhang X, Li WB, Chen Y, Huang X, Sun L, Luo W, Netzer WJ, Threadgill R, Wiegand G, Wang R, Cohen SN, Greengard P, Liao FF, Li L, Xu H., 2009
Presenilin/γ-secretase-dependent processing of APP regulates EGFR expression., Zhang YW*, Wang R, Liu Q, Zhang H, Liao FF, Xu H*, 2007

Neurodegenerative Diseases Alzheimer'S Disease Cellular Mechanisms Molecular Mechanisms Pathogenesis Neurobiology Protein Metabolism Synaptic Function Neuronal Death Genetic Identification

Yujun Hou - Tongji University

Gang Pei - Tongji University

Ru Zhang - Tongji University

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