Professor | Ligang Wu | Asia Growth Partners

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Name	Ligang Wu
Contact Information	lgwu@sibcb.ac.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Ligang Wu

Contact Information

lgwu@sibcb.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1996-09 to 2001-06 PhD: Shanghai Institute of Plant Physiology, Chinese Academy of Sciences 1992-09 to 1996-06 Bachelor's: Shanghai Jiao Tong University
Work Experience	2020-05 to Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Researcher 2008-06 to 2020-04 - Chinese Academy of Sciences, Shanghai Institute of Biochemistry and Cell Biology - Researcher 2001-12 to 2008-06 - New York University - Postdoctoral Researcher
Awards	New RNAi precursor and its preparation and application (2017): Patent No. 201310068534.3

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1996-09 to 2001-06 PhD: Shanghai Institute of Plant Physiology, Chinese Academy of Sciences
1992-09 to 1996-06 Bachelor's: Shanghai Jiao Tong University

Work Experience

2020-05 to Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Researcher
2008-06 to 2020-04 - Chinese Academy of Sciences, Shanghai Institute of Biochemistry and Cell Biology - Researcher
2001-12 to 2008-06 - New York University - Postdoctoral Researcher

Awards

New RNAi precursor and its preparation and application (2017): Patent No. 201310068534.3

Areas of Focus	Molecular mechanisms of mRNA and small RNA regulation Design and development of RNA drugs Development of new high-throughput sequencing methods and their application in disease diagnosis and treatment
Publications	Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes, Ligang Wu, 2024 Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease, Ligang Wu, 2024 Extracellular vesicle long RNA markers of early-stage lung adenocarcinoma, Ligang Wu, 2023 The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters, Ligang Wu, 2023 Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index, Ligang Wu, 2022 Exosome Mediated Cytosolic Cisplatin Delivery Through Clathrin-Independent Endocytosis and Enhanced Anti-cancer Effect via Avoiding Endosome Trapping in Cisplatin-Resistant Ovarian Cancer, Ligang Wu, 2022 Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans, Ligang Wu, 2022 The piRNA pathway is essential for generating functional oocytes in golden hamsters, Ligang Wu, 2021 Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP, Ligang Wu, 2020 Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles, Ligang Wu, 2020 SpyCLIP: an easy-to-use and high-throughput compatible CLIP platform for the characterization of protein–RNA interactions with high accuracy, Ligang Wu, 2019 An Improved NaIO4 Oxidation and Deep-Sequencing Method for Detecting 3′Terminal Methylation of Small RNAs in Low-Input RNA Samples, Ligang Wu, 2019 Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization, Ligang Wu, 2019 Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes, Ligang Wu, 2019 Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells, Ligang Wu, 2019 Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain, Ligang Wu, 2018 Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi, Ligang Wu, 2018 Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals, Ligang Wu, 2017 Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients, Ligang Wu, 2017 Profiling of miRNAs in porcine germ cells during spermatogenesis, Ligang Wu, 2017 Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, Ligang Wu, 2017 Telomeric TERB1-TRF1 interaction is crucial for male meiosis, Ligang Wu, 2017 Highly sensitive sequencing reveals dynamic modifications and activities of small RNAs in mouse oocytes and early embryos, Ligang Wu, 2016 YTHDF2 destabilizes m 6 A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex, Ligang Wu, 2016 Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells, Ligang Wu, 2015 Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects, Ligang Wu, 2015 MicroRNA-mediated repression of nonsense mRNAs, Ligang Wu, 2014 CCR4-NOT deadenylates RISC-associated mRNA in human cells., Ligang Wu, 2010 Examining the influence of microRNA on translation and mRNA decay., Ligang Wu, 2008 Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs, Ligang Wu, 2008 MicroRNAs direct rapid deadenylation of mRNA, Ligang Wu, 2006 Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells, Ligang Wu, 2005 Importance of translation and non-nucleolytic Ago proteins for on-target RNA interference, Ligang Wu, 2005

Areas of Focus

Molecular mechanisms of mRNA and small RNA regulation
Design and development of RNA drugs
Development of new high-throughput sequencing methods and their application in disease diagnosis and treatment

Publications

Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes, Ligang Wu, 2024
Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease, Ligang Wu, 2024
Extracellular vesicle long RNA markers of early-stage lung adenocarcinoma, Ligang Wu, 2023
The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters, Ligang Wu, 2023
Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index, Ligang Wu, 2022
Exosome Mediated Cytosolic Cisplatin Delivery Through Clathrin-Independent Endocytosis and Enhanced Anti-cancer Effect via Avoiding Endosome Trapping in Cisplatin-Resistant Ovarian Cancer, Ligang Wu, 2022
Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans, Ligang Wu, 2022
The piRNA pathway is essential for generating functional oocytes in golden hamsters, Ligang Wu, 2021
Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP, Ligang Wu, 2020
Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles, Ligang Wu, 2020
SpyCLIP: an easy-to-use and high-throughput compatible CLIP platform for the characterization of protein–RNA interactions with high accuracy, Ligang Wu, 2019
An Improved NaIO4 Oxidation and Deep-Sequencing Method for Detecting 3′Terminal Methylation of Small RNAs in Low-Input RNA Samples, Ligang Wu, 2019
Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization, Ligang Wu, 2019
Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes, Ligang Wu, 2019
Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells, Ligang Wu, 2019
Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain, Ligang Wu, 2018
Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi, Ligang Wu, 2018
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals, Ligang Wu, 2017
Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients, Ligang Wu, 2017
Profiling of miRNAs in porcine germ cells during spermatogenesis, Ligang Wu, 2017
Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, Ligang Wu, 2017
Telomeric TERB1-TRF1 interaction is crucial for male meiosis, Ligang Wu, 2017
Highly sensitive sequencing reveals dynamic modifications and activities of small RNAs in mouse oocytes and early embryos, Ligang Wu, 2016
YTHDF2 destabilizes m 6 A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex, Ligang Wu, 2016
Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells, Ligang Wu, 2015
Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects, Ligang Wu, 2015
MicroRNA-mediated repression of nonsense mRNAs, Ligang Wu, 2014
CCR4-NOT deadenylates RISC-associated mRNA in human cells., Ligang Wu, 2010
Examining the influence of microRNA on translation and mRNA decay., Ligang Wu, 2008
Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs, Ligang Wu, 2008
MicroRNAs direct rapid deadenylation of mRNA, Ligang Wu, 2006
Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells, Ligang Wu, 2005
Importance of translation and non-nucleolytic Ago proteins for on-target RNA interference, Ligang Wu, 2005

Mrna Small Rna Regulation Rna Drugs High-Throughput Sequencing Disease Diagnosis Treatment Molecular Mechanisms Development Application

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