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Ligang Wu
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Mrna
Small Rna
Regulation
Rna Drugs
High-Throughput Sequencing
Disease Diagnosis
Treatment
Molecular Mechanisms
Development
Application
Areas of Focus
- Molecular mechanisms of mRNA and small RNA regulation
- Design and development of RNA drugs
- Development of new high-throughput sequencing methods and their application in disease diagnosis and treatment
Work Experience
- 2020-05 to Present - Chinese Academy of Sciences, Center for Excellence in Molecular Cell Science - Researcher
- 2008-06 to 2020-04 - Chinese Academy of Sciences, Shanghai Institute of Biochemistry and Cell Biology - Researcher
- 2001-12 to 2008-06 - New York University - Postdoctoral Researcher
Academic Background & Achievements
- 1996-09 to 2001-06 PhD: Shanghai Institute of Plant Physiology, Chinese Academy of Sciences
- 1992-09 to 1996-06 Bachelor's: Shanghai Jiao Tong University
Publications
- Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes, Ligang Wu, 2024
- Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease, Ligang Wu, 2024
- Extracellular vesicle long RNA markers of early-stage lung adenocarcinoma, Ligang Wu, 2023
- The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters, Ligang Wu, 2023
- Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index, Ligang Wu, 2022
- Exosome Mediated Cytosolic Cisplatin Delivery Through Clathrin-Independent Endocytosis and Enhanced Anti-cancer Effect via Avoiding Endosome Trapping in Cisplatin-Resistant Ovarian Cancer, Ligang Wu, 2022
- Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans, Ligang Wu, 2022
- The piRNA pathway is essential for generating functional oocytes in golden hamsters, Ligang Wu, 2021
- Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP, Ligang Wu, 2020
- Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles, Ligang Wu, 2020
- SpyCLIP: an easy-to-use and high-throughput compatible CLIP platform for the characterization of protein–RNA interactions with high accuracy, Ligang Wu, 2019
- An Improved NaIO4 Oxidation and Deep-Sequencing Method for Detecting 3′Terminal Methylation of Small RNAs in Low-Input RNA Samples, Ligang Wu, 2019
- Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization, Ligang Wu, 2019
- Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes, Ligang Wu, 2019
- Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells, Ligang Wu, 2019
- Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain, Ligang Wu, 2018
- Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi, Ligang Wu, 2018
- Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals, Ligang Wu, 2017
- Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients, Ligang Wu, 2017
- Profiling of miRNAs in porcine germ cells during spermatogenesis, Ligang Wu, 2017
- Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, Ligang Wu, 2017
- Telomeric TERB1-TRF1 interaction is crucial for male meiosis, Ligang Wu, 2017
- Highly sensitive sequencing reveals dynamic modifications and activities of small RNAs in mouse oocytes and early embryos, Ligang Wu, 2016
- YTHDF2 destabilizes m 6 A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex, Ligang Wu, 2016
- Correction of a genetic disease by CRISPR-Cas9-mediated gene editing in mouse spermatogonial stem cells, Ligang Wu, 2015
- Ribozyme-enhanced single-stranded Ago2-processed interfering RNA triggers efficient gene silencing with fewer off-target effects, Ligang Wu, 2015
- MicroRNA-mediated repression of nonsense mRNAs, Ligang Wu, 2014
- CCR4-NOT deadenylates RISC-associated mRNA in human cells., Ligang Wu, 2010
- Examining the influence of microRNA on translation and mRNA decay., Ligang Wu, 2008
- Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs, Ligang Wu, 2008
- MicroRNAs direct rapid deadenylation of mRNA, Ligang Wu, 2006
- Micro-RNA Regulation of the Mammalian lin-28 Gene during Neuronal Differentiation of Embryonal Carcinoma Cells, Ligang Wu, 2005
- Importance of translation and non-nucleolytic Ago proteins for on-target RNA interference, Ligang Wu, 2005
Awards
- New RNAi precursor and its preparation and application (2017): Patent No. 201310068534.3
