Professor | 吴立刚 | 数字化转型顾问

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Name	吴立刚
Contact Information	lgwu@sibcb.ac.cn
Language ability	中文, 英语
Province	上海

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Name

吴立刚

Contact Information

lgwu@sibcb.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Life Sciences
Academic Background & Achievements	1996-09 至 2001-06 博士: 中国科学院上海植物生理研究所 1992-09 至 1996-06 本科: 上海交通大学
Work Experience	2020-05 至今 - 中国科学院分子细胞卓越创新中心 - 研究员 2008-06 至 2020-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 研究员 2001-12 至 2008-06 - 纽约大学 - 博士后
Awards	新型RNAi前体及其制备和应用 (2017): 专利号: 201310068534.3

University/Lab Affiliation and Title

中国科学院大学

Faculty

Life Sciences

Academic Background & Achievements

1996-09 至 2001-06 博士: 中国科学院上海植物生理研究所
1992-09 至 1996-06 本科: 上海交通大学

Work Experience

2020-05 至今 - 中国科学院分子细胞卓越创新中心 - 研究员
2008-06 至 2020-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 研究员
2001-12 至 2008-06 - 纽约大学 - 博士后

Awards

新型RNAi前体及其制备和应用 (2017): 专利号: 201310068534.3

Areas of Focus	mRNA和小RNA调控的分子机制 RNA药物的设计与开发新的高通量测序方法开发及其在疾病诊疗中的应用
Publications	Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes, 吴立刚, 2024 Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease, 吴立刚, 2024 Extracellular vesicle long RNA markers of early-stage lung adenocarcinoma, 吴立刚, 2023 The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters, 吴立刚, 2023 Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index, 吴立刚, 2022 Exosome Mediated Cytosolic Cisplatin Delivery Through Clathrin-Independent Endocytosis and Enhanced Anti-cancer Effect via Avoiding Endosome Trapping in Cisplatin-Resistant Ovarian Cancer, 吴立刚, 2022 Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans, 吴立刚, 2022 The piRNA pathway is essential for generating functional oocytes in golden hamsters, 吴立刚, 2021 Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP, 吴立刚, 2020 Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles, 吴立刚, 2020 SpyCLIP: an easy-to-use and high-throughput compatible CLIP platform for the characterization of protein–RNA interactions with high accuracy, 吴立刚, 2019 An Improved NaIO4 Oxidation and Deep-Sequencing Method for Detecting 3′Terminal Methylation of Small RNAs in Low-Input RNA Samples, 吴立刚, 2019 Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization, 吴立刚, 2019 Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes, 吴立刚, 2019 Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells, 吴立刚, 2019 Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain, 吴立刚, 2018 Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi, 吴立刚, 2018 Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals, 吴立刚, 2017 Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients, 吴立刚, 2017 Profiling of miRNAs in porcine germ cells during spermatogenesis, 吴立刚, 2017 Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, 吴立刚, 2017 Telomeric TERB1-TRF1 interaction is crucial for

Areas of Focus

mRNA和小RNA调控的分子机制
RNA药物的设计与开发
新的高通量测序方法开发及其在疾病诊疗中的应用

Publications

Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes, 吴立刚, 2024
Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease, 吴立刚, 2024
Extracellular vesicle long RNA markers of early-stage lung adenocarcinoma, 吴立刚, 2023
The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters, 吴立刚, 2023
Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index, 吴立刚, 2022
Exosome Mediated Cytosolic Cisplatin Delivery Through Clathrin-Independent Endocytosis and Enhanced Anti-cancer Effect via Avoiding Endosome Trapping in Cisplatin-Resistant Ovarian Cancer, 吴立刚, 2022
Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans, 吴立刚, 2022
The piRNA pathway is essential for generating functional oocytes in golden hamsters, 吴立刚, 2021
Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP, 吴立刚, 2020
Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles, 吴立刚, 2020
SpyCLIP: an easy-to-use and high-throughput compatible CLIP platform for the characterization of protein–RNA interactions with high accuracy, 吴立刚, 2019
An Improved NaIO4 Oxidation and Deep-Sequencing Method for Detecting 3′Terminal Methylation of Small RNAs in Low-Input RNA Samples, 吴立刚, 2019
Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization, 吴立刚, 2019
Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes, 吴立刚, 2019
Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells, 吴立刚, 2019
Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain, 吴立刚, 2018
Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi, 吴立刚, 2018
Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals, 吴立刚, 2017
Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients, 吴立刚, 2017
Profiling of miRNAs in porcine germ cells during spermatogenesis, 吴立刚, 2017
Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, 吴立刚, 2017
Telomeric TERB1-TRF1 interaction is crucial for

Mrna 小Rna 调控 Rna药物高通量测序疾病诊断治疗分子机制开发应用

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