Upload Avatar (500 x 500)
吴立刚
Life Science
中国科学院大学
上海
Language: 中文, 英语
Mrna
小Rna
调控
Rna药物
高通量测序
疾病诊断
治疗
分子机制
开发
应用
Areas of Focus
- mRNA和小RNA调控的分子机制
- RNA药物的设计与开发
- 新的高通量测序方法开发及其在疾病诊疗中的应用
Work Experience
- 2020-05 至今 - 中国科学院分子细胞卓越创新中心 - 研究员
- 2008-06 至 2020-04 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 研究员
- 2001-12 至 2008-06 - 纽约大学 - 博士后
Academic Background & Achievements
- 1996-09 至 2001-06 博士: 中国科学院上海植物生理研究所
- 1992-09 至 1996-06 本科: 上海交通大学
Publications
- Divergent composition and transposon-silencing activity of small RNAs in mammalian oocytes, 吴立刚, 2024
- Candidate biomarkers of EV-microRNA in detecting REM sleep behavior disorder and Parkinson’s disease, 吴立刚, 2024
- Extracellular vesicle long RNA markers of early-stage lung adenocarcinoma, 吴立刚, 2023
- The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters, 吴立刚, 2023
- Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index, 吴立刚, 2022
- Exosome Mediated Cytosolic Cisplatin Delivery Through Clathrin-Independent Endocytosis and Enhanced Anti-cancer Effect via Avoiding Endosome Trapping in Cisplatin-Resistant Ovarian Cancer, 吴立刚, 2022
- Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans, 吴立刚, 2022
- The piRNA pathway is essential for generating functional oocytes in golden hamsters, 吴立刚, 2021
- Identifying Cleaved and Noncleaved Targets of Small Interfering RNAs and MicroRNAs in Mammalian Cells by SpyCLIP, 吴立刚, 2020
- Regeneration-Related Functional Cargoes in Mesenchymal Stem Cell-Derived Small Extracellular Vesicles, 吴立刚, 2020
- SpyCLIP: an easy-to-use and high-throughput compatible CLIP platform for the characterization of protein–RNA interactions with high accuracy, 吴立刚, 2019
- An Improved NaIO4 Oxidation and Deep-Sequencing Method for Detecting 3′Terminal Methylation of Small RNAs in Low-Input RNA Samples, 吴立刚, 2019
- Identification of small non-coding RNAs as sperm quality biomarkers for in vitro fertilization, 吴立刚, 2019
- Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes, 吴立刚, 2019
- Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells, 吴立刚, 2019
- Identification of substrates of the small RNA methyltransferase Hen1 in mouse spermatogonial stem cells and analysis of its methyl-transfer domain, 吴立刚, 2018
- Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi, 吴立刚, 2018
- Human Virus-Derived Small RNAs Can Confer Antiviral Immunity in Mammals, 吴立刚, 2017
- Distinct Expression Profiles and Novel Targets of MicroRNAs in Human Spermatogonia, Pachytene Spermatocytes, and Round Spermatids between OA Patients and NOA Patients, 吴立刚, 2017
- Profiling of miRNAs in porcine germ cells during spermatogenesis, 吴立刚, 2017
- Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, 吴立刚, 2017
- Telomeric TERB1-TRF1 interaction is crucial for
Awards
- 新型RNAi前体及其制备和应用 (2017): 专利号: 201310068534.3
