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Zhi Ke
Life Science
University of Chinese Academy of Sciences
Guangdong
Language: Chinese, German, English
Systems Biology: Computational Biology
Modeling
Simulation
Network Analysis
Pathway Analysis
Dynamic Systems
Biological Systems
Quantitative Biology
Systems Theory
Integrative Biology
Bioinformatics: Data Analysis
Genomics
Proteomics
Sequence Alignment
Machine Learning
Computational Tools
Biological Databases
Algorithm Development
Transcriptomics
Structural Biology
Areas of Focus
- Systems Biology
- Bioinformatics
Work Experience
- 2022-07~Present - Chinese Academy of Sciences Shenzhen Institute of Advanced Technology - Researcher
- 2019-01~2022-06 - German Federal Institute for Risk Assessment - Tenured Scientist
- 2014-05~2018-12 - Max Planck Institute for Molecular Genetics - Researcher, Group Leader (PI)
- 2009-11~2014-04 - University of Freiburg - Project Leader
- 2009-01~2009-10 - Humboldt University - Postdoctoral Researcher
Academic Background & Achievements
- 2005-08--2008-10 PhD: Humboldt University
- 2002-09--2005-07 Master's: Tsinghua University
- 1998-09--2002-06 Bachelor's: South-Central University for Nationalities
Publications
- Liebig’s law of the minimum in the TGF-β/SMAD pathway, Corresponding Author, 2024
- Machine learning unveils RNA polymerase II binding as a predictor for SMAD2‐dependent transcription dynamics in response to Actvin signalling, Corresponding Author, 2024
- PhyloVelo enhances transcriptomic velocity field mapping using monotonically expressed genes, 6th Author, 2023
- Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications, 3rd Author, 2020
- Cell-type-specific role of CHK2 in mediating DNA damage-induced G2 cell cycle arrest, Corresponding Author, 2020
- Molecular Engineering of the TGF-β Signaling Pathway, Corresponding Author, 2019
- eDetect: A Fast Error Detection and Correction Tool for Live Cell Imaging Data Analysis, Corresponding Author, 2019
- Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21, Corresponding Author, 2019
- Spatiotemporal Control of TGF- β Signaling with Light, Corresponding Author, 2018
- Quantitative analysis of transient and sustained transforming growth factor‐β signaling dynamics, Corresponding Author, 2011
- SBML-PET-MPI: a parallel parameter estimation tool for Systems Biology Markup Language based models, Corresponding Author, 2011
- Time-Dependent Quantitative Multicomponent Control of the G(1)-S Network by the Stress-Activated Protein Kinase Hog1 upon Osmostress, 2nd Author, 2011
