Professor | Xiangqian Kong | Asia Growth Partners

Name	Xiangqian Kong
Contact Information	kong_xiangqian@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Xiangqian Kong

Contact Information

kong_xiangqian@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2009-09 to 2014-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 2005-09 to 2009-07 Bachelor's Degree: Shandong University, School of Pharmacy
Work Experience	2020-08 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2015-02 to 2020-07 - Johns Hopkins University - Postdoctoral Researcher
Awards	AACR-Get Your Rear in Gear Philadelphia Scholar in Training Award (2019): First Prize

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2009-09 to 2014-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2005-09 to 2009-07 Bachelor's Degree: Shandong University, School of Pharmacy

Work Experience

2020-08 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2015-02 to 2020-07 - Johns Hopkins University - Postdoctoral Researcher

Awards

AACR-Get Your Rear in Gear Philadelphia Scholar in Training Award (2019): First Prize

Areas of Focus	Epigenetics and Precision Medicine in Cancer Molecular Mechanisms of Cancer Transcription Abnormalities and Innovative Drug Discovery Target Validation and Innovative Drug Discovery Based on New Mechanisms of Epigenetic Regulation
Publications	Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties, Corresponding Author, 2022 A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones, 10th Author, 2021 Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, 16th Author, 2021 Epigenetic Therapy Inhibits Metastases by Disrupting Premetastatic Niches, 9th Author, 2021 High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation, 4th Author, 2020 Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, 1st Author, 2019 Aging-like Spontaneous Epigenetic Silencing Facilitates WntActivation, Stemness, and Braf V600E -InducedTumorigenesis, 7th Author, 2019 Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, 2nd Author, 2018 DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk, 7th Author, 2018 developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors, 7th Author, 2018 Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells, 5th Author, 2017 Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition, 1st Author, 2015 An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kruppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, 3rd Author, 2014 Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction, 3rd Author, 2014 K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5, 10th Author, 2014 Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants, 4th Author, 2014 Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2., 1st Author, 2014 Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin–mixed lineage leukaemia interface, 8th Author, 2014 c-MET kinase inhibitors: a patent review (2011-2013), 2nd Author, 2014 dna和组蛋白表观遗传修饰与糖尿病和肥胖的关系以及小分子抑制剂的研究进展, 4th Author, 2013 Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, 4th Author, 2013 Targeting Epigenetics in Nervous System Disease, 3rd Author, 2013 Salvianolic Acid A, a Novel Matrix Metalloproteinase-9 Inhibitor, Prevents Cardiac Remodeling in Spontaneously Hypertensive Rats, 7th Author, 2013 Application of epigenome-modifying small molecules in induced pluripotent stem cells., 2nd Author, 2013 Structure-based computational study of the hydrolysis of New Delhi metallo-beta-lactmase-1, 5th Author, 2013 Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1, 6th Author, 2013 A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-beta-lactamase-1, 4th Author, 2013 Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease, 6th Author, 2013 组蛋白乙酰转移酶hMOF小分子抑制剂的发现及应用研究, 1st Author, 2013 Computational drug discovery, 3rd Author, 2012 Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA, 3rd Author, 2012 Development of a novel class of B-Raf V600E -selective inhibitors through virtual screening and hierarchical hit optimization, 1st Author, 2012 Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay, 4th Author, 2012 Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli, 2nd Author, 2011 Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study, Corresponding Author, 2011 Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant, 5th Author, 2011 Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase, 6th Author, 2011 鞘氨醇磷酸酯调控机制的研究进展, 2nd Author, 2010

Areas of Focus

Epigenetics and Precision Medicine in Cancer
Molecular Mechanisms of Cancer Transcription Abnormalities and Innovative Drug Discovery
Target Validation and Innovative Drug Discovery Based on New Mechanisms of Epigenetic Regulation

Publications

Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties, Corresponding Author, 2022
A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones, 10th Author, 2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, 16th Author, 2021
Epigenetic Therapy Inhibits Metastases by Disrupting Premetastatic Niches, 9th Author, 2021
High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation, 4th Author, 2020
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, 1st Author, 2019
Aging-like Spontaneous Epigenetic Silencing Facilitates WntActivation, Stemness, and Braf V600E -InducedTumorigenesis, 7th Author, 2019
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, 2nd Author, 2018
DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk, 7th Author, 2018
developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors, 7th Author, 2018
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells, 5th Author, 2017
Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition, 1st Author, 2015
An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kruppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, 3rd Author, 2014
Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction, 3rd Author, 2014
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5, 10th Author, 2014
Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants, 4th Author, 2014
Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2., 1st Author, 2014
Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin–mixed lineage leukaemia interface, 8th Author, 2014
c-MET kinase inhibitors: a patent review (2011-2013), 2nd Author, 2014
dna和组蛋白表观遗传修饰与糖尿病和肥胖的关系以及小分子抑制剂的研究进展, 4th Author, 2013
Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, 4th Author, 2013
Targeting Epigenetics in Nervous System Disease, 3rd Author, 2013
Salvianolic Acid A, a Novel Matrix Metalloproteinase-9 Inhibitor, Prevents Cardiac Remodeling in Spontaneously Hypertensive Rats, 7th Author, 2013
Application of epigenome-modifying small molecules in induced pluripotent stem cells., 2nd Author, 2013
Structure-based computational study of the hydrolysis of New Delhi metallo-beta-lactmase-1, 5th Author, 2013
Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1, 6th Author, 2013
A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-beta-lactamase-1, 4th Author, 2013
Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease, 6th Author, 2013
组蛋白乙酰转移酶hMOF小分子抑制剂的发现及应用研究, 1st Author, 2013
Computational drug discovery, 3rd Author, 2012
Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA, 3rd Author, 2012
Development of a novel class of B-Raf V600E -selective inhibitors through virtual screening and hierarchical hit optimization, 1st Author, 2012
Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay, 4th Author, 2012
Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli, 2nd Author, 2011
Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study, Corresponding Author, 2011
Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant, 5th Author, 2011
Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase, 6th Author, 2011
鞘氨醇磷酸酯调控机制的研究进展, 2nd Author, 2010

Epigenetics Precision Medicine Cancer Transcription Molecular Mechanisms Drug Discovery Target Validation Regulation Innovative Therapeutics

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Jun Che - Southern University of Science and Technology

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