Areas of Focus
- Epigenetics and Precision Medicine in Cancer
- Molecular Mechanisms of Cancer Transcription Abnormalities and Innovative Drug Discovery
- Target Validation and Innovative Drug Discovery Based on New Mechanisms of Epigenetic Regulation
Work Experience
- 2020-08 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
- 2015-02 to 2020-07 - Johns Hopkins University - Postdoctoral Researcher
Academic Background & Achievements
- 2009-09 to 2014-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2005-09 to 2009-07 Bachelor's Degree: Shandong University, School of Pharmacy
Publications
- Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties, Corresponding Author, 2022
- A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones, 10th Author, 2021
- Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, 16th Author, 2021
- Epigenetic Therapy Inhibits Metastases by Disrupting Premetastatic Niches, 9th Author, 2021
- High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation, 4th Author, 2020
- Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, 1st Author, 2019
- Aging-like Spontaneous Epigenetic Silencing Facilitates WntActivation, Stemness, and Braf V600E -InducedTumorigenesis, 7th Author, 2019
- Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, 2nd Author, 2018
- DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk, 7th Author, 2018
- developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors, 7th Author, 2018
- Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells, 5th Author, 2017
- Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition, 1st Author, 2015
- An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kruppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, 3rd Author, 2014
- Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction, 3rd Author, 2014
- K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5, 10th Author, 2014
- Flumatinib, a selective inhibitor of BCR-ABL/PDGFR/KIT, effectively overcomes drug resistance of certain KIT mutants, 4th Author, 2014
- Astemizole arrests the proliferation of cancer cells by disrupting the EZH2-EED interaction of polycomb repressive complex 2., 1st Author, 2014
- Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin–mixed lineage leukaemia interface, 8th Author, 2014
- c-MET kinase inhibitors: a patent review (2011-2013), 2nd Author, 2014
- dna和组蛋白表观遗传修饰与糖尿病和肥胖的关系以及小分子抑制剂的研究进展, 4th Author, 2013
- Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, 4th Author, 2013
- Targeting Epigenetics in Nervous System Disease, 3rd Author, 2013
- Salvianolic Acid A, a Novel Matrix Metalloproteinase-9 Inhibitor, Prevents Cardiac Remodeling in Spontaneously Hypertensive Rats, 7th Author, 2013
- Application of epigenome-modifying small molecules in induced pluripotent stem cells., 2nd Author, 2013
- Structure-based computational study of the hydrolysis of New Delhi metallo-beta-lactmase-1, 5th Author, 2013
- Theoretical Insights into Catalytic Mechanism of Protein Arginine Methyltransferase 1, 6th Author, 2013
- A quantum mechanics/molecular mechanics study on the hydrolysis mechanism of New Delhi metallo-beta-lactamase-1, 4th Author, 2013
- Helix Unfolding/Refolding Characterizes the Functional Dynamics of Staphylococcus aureus Clp Protease, 6th Author, 2013
- 组蛋白乙酰转移酶hMOF小分子抑制剂的发现及应用研究, 1st Author, 2013
- Computational drug discovery, 3rd Author, 2012
- Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA, 3rd Author, 2012
- Development of a novel class of B-Raf V600E -selective inhibitors through virtual screening and hierarchical hit optimization, 1st Author, 2012
- Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay, 4th Author, 2012
- Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli, 2nd Author, 2011
- Catalytic Mechanism Investigation of Lysine-Specific Demethylase 1 (LSD1): A Computational Study, Corresponding Author, 2011
- Molecular Basis of NDM-1, a New Antibiotic Resistance Determinant, 5th Author, 2011
- Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase, 6th Author, 2011
- 鞘氨醇磷酸酯调控机制的研究进展, 2nd Author, 2010
Awards
- AACR-Get Your Rear in Gear Philadelphia Scholar in Training Award (2019): First Prize
