Professor | 孔祥谦 | 数字化转型顾问

Name	孔祥谦
Contact Information	kong_xiangqian@gibh.ac.cn
Language ability	中文, 英语
Province	广东

Name

孔祥谦

Contact Information

kong_xiangqian@gibh.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2009-09 至 2014-07 博士学位: 中国科学院上海药物研究所 2005-09 至 2009-07 学士学位: 山东大学药学院
Work Experience	2020-08 至今 - 中国科学院广州生物医药与健康研究院 - 研究员 2015-02 至 2020-07 - 约翰霍普金斯大学 - 博士后
Awards	AACR-Get Your Rear in Gear Philadelphia Scholar in Training Award (2019): 一等奖

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2009-09 至 2014-07 博士学位: 中国科学院上海药物研究所
2005-09 至 2009-07 学士学位: 山东大学药学院

Work Experience

2020-08 至今 - 中国科学院广州生物医药与健康研究院 - 研究员
2015-02 至 2020-07 - 约翰霍普金斯大学 - 博士后

Awards

AACR-Get Your Rear in Gear Philadelphia Scholar in Training Award (2019): 一等奖

Areas of Focus	肿瘤表观遗传学和药物精准应用肿瘤转录异常的分子机制和创新药物发现基于表观遗传调控新机制的靶标确证和创新药物发现
Publications	Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties, 通讯作者, 2022 A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones, 第10作者, 2021 Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, 第16作者, 2021 Epigenetic Therapy Inhibits Metastases by Disrupting Premetastatic Niches, 第9作者, 2021 High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation, 第4作者, 2020 Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, 第1作者, 2019 Aging-like Spontaneous Epigenetic Silencing Facilitates WntActivation, Stemness, and Braf V600E -InducedTumorigenesis, 第7作者, 2019 Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, 第2作者, 2018 DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk, 第7作者, 2018 developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors, 第7作者, 2018 Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells, 第5作者, 2017 Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition, 第1作者, 2015 An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kruppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, 第3作者, 2014 Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction, 第3作者, 2014 K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5, 第10作者

Areas of Focus

肿瘤表观遗传学和药物精准应用
肿瘤转录异常的分子机制和创新药物发现
基于表观遗传调控新机制的靶标确证和创新药物发现

Publications

Design, synthesis, and biological evaluation of novel carbazole derivatives as potent DNMT1 inhibitors with reasonable PK properties, 通讯作者, 2022
A Cost-Effective and Non-Invasive pfeRNA-Based Test Differentiates Benign and Suspicious Pulmonary Nodules from Malignant Ones, 第10作者, 2021
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction, 第16作者, 2021
Epigenetic Therapy Inhibits Metastases by Disrupting Premetastatic Niches, 第9作者, 2021
High-resolution Epigenome Mapping Reveals Distinct and Divergent Roles for UHRF1 in the Maintenance of DNA Methylation, 第4作者, 2020
Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties, 第1作者, 2019
Aging-like Spontaneous Epigenetic Silencing Facilitates WntActivation, Stemness, and Braf V600E -InducedTumorigenesis, 第7作者, 2019
Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1, 第2作者, 2018
DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk, 第7作者, 2018
developmentofahighthroughputfluorescencepolarizationassayforthediscoveryofezh2eedinteractioninhibitors, 第7作者, 2018
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells, 第5作者, 2017
Functional interplay between the RK motif and linker segment dictates Oct4–DNA recognition, 第1作者, 2015
An Arginine-rich Motif of Ring Finger Protein 4 (RNF4) Oversees the Recruitment and Degradation of the Phosphorylated and SUMOylated Kruppel-associated Box Domain-associated Protein 1 (KAP1)/TRIM28 Protein during Genotoxic Stress, 第3作者, 2014
Catalytic Mechanism of Histone Acetyltransferase p300: From the Proton Transfer to Acetylation Reaction, 第3作者, 2014
K63-linked polyubiquitination of transcription factor IRF1 is essential for IL-1-induced production of chemokines CXCL10 and CCL5, 第10作者

表观遗传学精准医学癌症转录分子机制药物发现靶标验证调控创新治疗

肖荣权 - 南方科技大学

平洁 - 武汉大学

王瑾 - 武汉大学

Area of Focus
肿瘤 | 免疫学 | 癌症 | 细胞反应 | 免疫系统 | 肿瘤学 | 研究 | 治疗 | 分子机制 | 临床应用

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