Professor | Yi Li | Asia Growth Partners

Name	Yi Li
Contact Information	liyi@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Yi Li

Contact Information

liyi@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2009-09--2014-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 2005-09--2009-07 Bachelor's: Wuhan University
Work Experience	2022-06~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher 2018-12~2022-04 - University of Texas, USA - Postdoctoral Researcher 2016-08~2018-11 - WuXi AppTec, Shanghai - Project Manager 2014-07~2016-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher 2009-09~2014-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD 2005-09~2009-07 - Wuhan University - Bachelor's

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2009-09--2014-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2005-09--2009-07 Bachelor's: Wuhan University

Work Experience

2022-06~Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Researcher
2018-12~2022-04 - University of Texas, USA - Postdoctoral Researcher
2016-08~2018-11 - WuXi AppTec, Shanghai - Project Manager
2014-07~2016-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Postdoctoral Researcher
2009-09~2014-07 - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - PhD
2005-09~2009-07 - Wuhan University - Bachelor's

Areas of Focus	Innovative drug development for anti-tumor and metabolic diseases
Publications	Discovery, X-ray Crystallography, and Anti-Inflammatory Activity of Bromodomain-Containing Protein 4 (BRD4) Inhibitors Targeting a Distinct New Binding Site, Yi Li, 2022 Target-Based Small Molecule Drug Discovery towards Novel Therapeutics for Inflammatory Bowel Diseases, Yi Li, 2021 Applications of Asymmetric Petasis Reaction in the Synthesis of Chiral Amines, Yi Li, 2021 Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives, Yi Li, 2021 Discovery of Phenanthridine Analogues as Novel Chemical Probes Disrupting the Binding of DNA to ΔFosB Homodimers and ΔFosB/JunD Heterodimers, Yi Li, 2020 Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Synthesis of Multifunctional Chiral alpha,alpha-Disubstituted Allylic Amine Derivatives, Yi Li, 2018 Simple Open-Chain Phosphite-Olefin as Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl alpha-Amino Acid Derivatives, Yi Li, 2016 Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol, Yi Li, 2015 A highly diastereoselective Friedel-Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles, Yi Li, 2015 Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin, Yi Li, 2014 Simple sulfur-olefins as new promising chiral ligands for asymmetric catalysis, Yi Li, 2014 Rhodium-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline 1,1-Dioxides, Yi Li, 2014 Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, Yi Li, 2013 A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation-cyclization sequence, Yi Li, 2013 Lewis-Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9-Aminofluorene Derivatives, Yi Li, 2013 Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids, Yi Li, 2012 Highly diastereoselective Friedel-Crafts reaction of arenes with N-tert-butanesulfinylimino ester towards the efficient synthesis of alpha-arylglycines, Yi Li, 2011 One-pot synthesis of furocoumarins via sequential Pd/Cu-catalyzed alkynylation and intramolecular hydroalkoxylation, Yi Li, 2010

Areas of Focus

Innovative drug development for anti-tumor and metabolic diseases

Publications

Discovery, X-ray Crystallography, and Anti-Inflammatory Activity of Bromodomain-Containing Protein 4 (BRD4) Inhibitors Targeting a Distinct New Binding Site, Yi Li, 2022
Target-Based Small Molecule Drug Discovery towards Novel Therapeutics for Inflammatory Bowel Diseases, Yi Li, 2021
Applications of Asymmetric Petasis Reaction in the Synthesis of Chiral Amines, Yi Li, 2021
Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic beta(2)/gamma(2)/delta(2)-Amino Acid Derivatives, Yi Li, 2021
Discovery of Phenanthridine Analogues as Novel Chemical Probes Disrupting the Binding of DNA to ΔFosB Homodimers and ΔFosB/JunD Heterodimers, Yi Li, 2020
Rhodium-Catalyzed Enantioselective Alkenylation of Cyclic Ketimines: Synthesis of Multifunctional Chiral alpha,alpha-Disubstituted Allylic Amine Derivatives, Yi Li, 2018
Simple Open-Chain Phosphite-Olefin as Ligand for Rh-Catalyzed Asymmetric Arylation of Cyclic Ketimines: Enantioselective Access to gem-Diaryl alpha-Amino Acid Derivatives, Yi Li, 2016
Facile synthesis of acridines via Pd(0)-diphosphine complex-catalyzed tandem coupling/cyclization protocol, Yi Li, 2015
A highly diastereoselective Friedel-Crafts reaction of indoles with isatin-derived N-sulfinyl ketimines towards the efficient synthesis of chiral tetrasubstituted 3-indolyl-3-aminooxindoles, Yi Li, 2015
Rhodium-Catalyzed Asymmetric Tandem Cyclization for Efficient and Rapid Access to Underexplored Heterocyclic Tertiary Allylic Alcohols Containing a Tetrasubstituted Olefin, Yi Li, 2014
Simple sulfur-olefins as new promising chiral ligands for asymmetric catalysis, Yi Li, 2014
Rhodium-Catalyzed Highly Enantioselective Arylation of Cyclic Diketimines: Efficient Synthesis of Chiral Tetrasubstituted 1,2,5-Thiadiazoline 1,1-Dioxides, Yi Li, 2014
Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action, Yi Li, 2013
A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation-cyclization sequence, Yi Li, 2013
Lewis-Acid-Catalyzed Intramolecular Aza-Friedel-Crafts Reaction of N-tert-Butanesulfinyl Imines: Efficient Synthesis of Optically Active 9-Aminofluorene Derivatives, Yi Li, 2013
Lewis Acid Promoted Highly Diastereoselective Petasis Borono-Mannich Reaction: Efficient Synthesis of Optically Active beta,gamma-Unsaturated alpha-Amino Acids, Yi Li, 2012
Highly diastereoselective Friedel-Crafts reaction of arenes with N-tert-butanesulfinylimino ester towards the efficient synthesis of alpha-arylglycines, Yi Li, 2011
One-pot synthesis of furocoumarins via sequential Pd/Cu-catalyzed alkynylation and intramolecular hydroalkoxylation, Yi Li, 2010

Anti-Tumor Metabolic Diseases Drug Development Innovation Research Pharmaceuticals Oncology Metabolism Therapeutics Biochemistry

Wanqiu Li - Southern University of Science and Technology

Bao Liang Song - Wuhan University

Han Han - Wuhan University

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