Professor | Xiaowei Wu | Asia Growth Partners

Name	Xiaowei Wu
Contact Information	wuxiaowei@simm.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Xiaowei Wu

Contact Information

wuxiaowei@simm.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2012-09--2017-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences 2008-09--2012-06 Bachelor's: Sichuan University
Work Experience	2018-06~2021-02 - Baylor College of Medicine - Postdoctoral Researcher 2017-08~2018-06 - H. Lee Moffitt Cancer Center and Research Institute - Postdoctoral Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2012-09--2017-07 PhD: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
2008-09--2012-06 Bachelor's: Sichuan University

Work Experience

2018-06~2021-02 - Baylor College of Medicine - Postdoctoral Researcher
2017-08~2018-06 - H. Lee Moffitt Cancer Center and Research Institute - Postdoctoral Researcher

Areas of Focus	Drug Chemistry Organic Synthesis
Publications	Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai, Mingyue Zheng, Hong Liu, 2021 Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-Pyrrolo1,2-aindol-3-ones via Rhodium Catalysis, Zhao, Fei, Gong, Xin, Lu, Yangbin, Qiao, Jin, Jia, Xiuwen, Ni, Hangcheng, Wu, Xiaowei, Zhang, Xiaoning, 2021 Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors, Wu Xiaowei, 2021 Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes, Wu, Xiaowei, Lu, Yangbin, Qiao, Jin, Dai, Wenhao, Jia, Xiuwen, Ni, Hangcheng, Zhang, Xiaoning, Liu, Hong, Zhao, Fei, 2020 Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution, Wu Xiaowei, Haitao Ji, 2020 Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates, Wu Xiaowei, 2020 Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design, Wang, Yulan, Dai, Yang, Wu, Xiaowei, Li, Fei, Liu, Bo, Li, Chunpu, Liu, Qiufeng, Zhou, Yuanyang, Wang, Bao, Zhu, Mingrui, Cui, Rongrong, Tan, Xiaoqin, Xiong, Zhaoping, Liu, Jia, Tan, Minjia, Xu, Yechun, Geng, Meiyu, Jiang, Hualiang, Liu, Hong, Ai, Jing, Zheng, Mingyue, 2019 The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design, Wu Xiaowei, 2019 Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes, Dai, Wenhao, Wu, Xiaowei, Li, Chunpu, Zhang, Rui, Wang, Jiang, Liu, Hong, 2018 Rhodium(III)-catalyzed C-H allylation of indoles with allyl alcohols via beta-hydroxide elimination, Wu, Xiaowei, Ji, Haitao, 2018 先导化合物结构优化策略（六）——改善化合物血浆稳定性, 吴小伟, 王江, 柳红, 2018 Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols, Wu, Xiaowei, Ji, Haitao, 2018 Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis, Wu Xiaowei, 2018 Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon, Wu Xiaowei, 2017 Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon, Wu, Xiaowei, Wang, Bao, Zhou, Yu, Liu, Hong, 2017 Ruthenium-Catalyzed Redox-Neutral 4+1 Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation, Wu, Xiaowei, Wang, Bao, Zhou, Shengbin, Zhou, Yu, Liu, Hong, 2017 Ruthenium(II)-Catalyzed Redox-Neutral 3+2 Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold, Xie, Yanan, Wu, Xiaowei, Li, Chunpu, Wang, Jiang, Li, Jian, Liu, Hong, 2017 Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides, Wu, Xiaowei, Zhang, Dengyou, Zhou, Shengbin, Gao, Feng, Liu, Hong, 2015 Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors, Yang, Wei, Li, Lixuan, Wang, Yulan, Wu, Xiaowei, Li, Tingting, Yang, Nan, Su, Mingbo, Sheng, Li, Zheng, Mingyue, Zang, Yi, Li, Jia, Liu, Hong, 2015 Design, synthesis and biological evaluation of 4-anilinothieno2,3-dpyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors, Yang, Wei, Li, Lixuan, Ji, Xun, Wu, Xiaowei, Su, Mingbo, Sheng, Li, Zang, Yi, Li, Jia, Liu, Hong, 2014

Areas of Focus

Drug Chemistry
Organic Synthesis

Publications

Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai, Mingyue Zheng, Hong Liu, 2021
Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-Pyrrolo1,2-aindol-3-ones via Rhodium Catalysis, Zhao, Fei, Gong, Xin, Lu, Yangbin, Qiao, Jin, Jia, Xiuwen, Ni, Hangcheng, Wu, Xiaowei, Zhang, Xiaoning, 2021
Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors, Wu Xiaowei, 2021
Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes, Wu, Xiaowei, Lu, Yangbin, Qiao, Jin, Dai, Wenhao, Jia, Xiuwen, Ni, Hangcheng, Zhang, Xiaoning, Liu, Hong, Zhao, Fei, 2020
Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution, Wu Xiaowei, Haitao Ji, 2020
Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates, Wu Xiaowei, 2020
Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design, Wang, Yulan, Dai, Yang, Wu, Xiaowei, Li, Fei, Liu, Bo, Li, Chunpu, Liu, Qiufeng, Zhou, Yuanyang, Wang, Bao, Zhu, Mingrui, Cui, Rongrong, Tan, Xiaoqin, Xiong, Zhaoping, Liu, Jia, Tan, Minjia, Xu, Yechun, Geng, Meiyu, Jiang, Hualiang, Liu, Hong, Ai, Jing, Zheng, Mingyue, 2019
The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design, Wu Xiaowei, 2019
Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes, Dai, Wenhao, Wu, Xiaowei, Li, Chunpu, Zhang, Rui, Wang, Jiang, Liu, Hong, 2018
Rhodium(III)-catalyzed C-H allylation of indoles with allyl alcohols via beta-hydroxide elimination, Wu, Xiaowei, Ji, Haitao, 2018
先导化合物结构优化策略（六）——改善化合物血浆稳定性, 吴小伟, 王江, 柳红, 2018
Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols, Wu, Xiaowei, Ji, Haitao, 2018
Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis, Wu Xiaowei, 2018
Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon, Wu Xiaowei, 2017
Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon, Wu, Xiaowei, Wang, Bao, Zhou, Yu, Liu, Hong, 2017
Ruthenium-Catalyzed Redox-Neutral 4+1 Annulation of Benzamides and Propargyl Alcohols via C-H Bond Activation, Wu, Xiaowei, Wang, Bao, Zhou, Shengbin, Zhou, Yu, Liu, Hong, 2017
Ruthenium(II)-Catalyzed Redox-Neutral 3+2 Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold, Xie, Yanan, Wu, Xiaowei, Li, Chunpu, Wang, Jiang, Li, Jian, Liu, Hong, 2017
Site-specific indolation of proline-based peptides via copper(II)-catalyzed oxidative coupling of tertiary amine N-oxides, Wu, Xiaowei, Zhang, Dengyou, Zhou, Shengbin, Gao, Feng, Liu, Hong, 2015
Design, synthesis and biological evaluation of isoquinoline-based derivatives as novel histone deacetylase inhibitors, Yang, Wei, Li, Lixuan, Wang, Yulan, Wu, Xiaowei, Li, Tingting, Yang, Nan, Su, Mingbo, Sheng, Li, Zheng, Mingyue, Zang, Yi, Li, Jia, Liu, Hong, 2015
Design, synthesis and biological evaluation of 4-anilinothieno2,3-dpyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors, Yang, Wei, Li, Lixuan, Ji, Xun, Wu, Xiaowei, Su, Mingbo, Sheng, Li, Zang, Yi, Li, Jia, Liu, Hong, 2014

Drug Chemistry Organic Synthesis Small Molecule Drugs Antitumor Antiviral Synthesis Methodology Pharmacological Activity Covalent Inhibitors Catalysis Heterocycles

Haibing Zhou - Wuhan University

Peng Liu - Wuhan University

Chunhao Yang - University of Chinese Academy of Sciences

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