Professor | 吴小伟 | 数字化转型顾问

Name	吴小伟
Contact Information	wuxiaowei@simm.ac.cn
Language ability	中文, 英语
Province	广东

Name

吴小伟

Contact Information

wuxiaowei@simm.ac.cn

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2012-09--2017-07 博士: 中国科学院上海药物研究所 2008-09--2012-06 学士: 四川大学
Work Experience	2018-06~2021-02 - 贝勒医学院 - 博士后 2017-08~2018-06 - H. Lee Moffitt癌症中心和研究所 - 博士后

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2012-09--2017-07 博士: 中国科学院上海药物研究所
2008-09--2012-06 学士: 四川大学

Work Experience

2018-06~2021-02 - 贝勒医学院 - 博士后
2017-08~2018-06 - H. Lee Moffitt癌症中心和研究所 - 博士后

Areas of Focus	药物化学有机合成
Publications	Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai, Mingyue Zheng, Hong Liu, 2021 Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-Pyrrolo1,2-aindol-3-ones via Rhodium Catalysis, Zhao, Fei, Gong, Xin, Lu, Yangbin, Qiao, Jin, Jia, Xiuwen, Ni, Hangcheng, Wu, Xiaowei, Zhang, Xiaoning, 2021 Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors, Wu Xiaowei, 2021 Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes, Wu, Xiaowei, Lu, Yangbin, Qiao, Jin, Dai, Wenhao, Jia, Xiuwen, Ni, Hangcheng, Zhang, Xiaoning, Liu, Hong, Zhao, Fei, 2020 Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution, Wu Xiaowei, Haitao Ji, 2020 Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates, Wu Xiaowei, 2020 Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design, Wang, Yulan, Dai, Yang, Wu, Xiaowei, Li, Fei, Liu, Bo, Li, Chunpu, Liu, Qiufeng, Zhou, Yuanyang, Wang, Bao, Zhu, Mingrui, Cui, Rongrong, Tan, Xiaoqin, Xiong, Zhaoping, Liu, Jia, Tan, Minjia, Xu, Yechun, Geng, Meiyu, Jiang, Hualiang, Liu, Hong, Ai, Jing, Zheng, Mingyue, 2019 The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design, Wu Xiaowei, 2019 Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes, Dai, Wenhao, Wu, Xiaowei, Li, Chunpu, Zhang, Rui, Wang, Jiang, Liu, Hong, 2018 Rhodium(III)-catalyzed C-H allylation of indoles with allyl alcohols via beta-hydroxide elimination, Wu, Xiaowei, Ji, Haitao, 2018 先导化合物结构优化策略（六）——改善化合物血浆稳定性, 吴小伟, 王江, 柳红, 2018 Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols, Wu, Xiaowei, Ji, Haitao, 2018 Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis, Wu Xiaowei, 2018 Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon, Wu Xiaowei, 2017 Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon, Wu, Xiaowei, Wang, Bao, Zhou, Yu, Liu, Hong, 2017

Areas of Focus

药物化学
有机合成

Publications

Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai, Mingyue Zheng, Hong Liu, 2021
Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-Pyrrolo1,2-aindol-3-ones via Rhodium Catalysis, Zhao, Fei, Gong, Xin, Lu, Yangbin, Qiao, Jin, Jia, Xiuwen, Ni, Hangcheng, Wu, Xiaowei, Zhang, Xiaoning, 2021
Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors, Wu Xiaowei, 2021
Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes, Wu, Xiaowei, Lu, Yangbin, Qiao, Jin, Dai, Wenhao, Jia, Xiuwen, Ni, Hangcheng, Zhang, Xiaoning, Liu, Hong, Zhao, Fei, 2020
Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution, Wu Xiaowei, Haitao Ji, 2020
Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates, Wu Xiaowei, 2020
Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design, Wang, Yulan, Dai, Yang, Wu, Xiaowei, Li, Fei, Liu, Bo, Li, Chunpu, Liu, Qiufeng, Zhou, Yuanyang, Wang, Bao, Zhu, Mingrui, Cui, Rongrong, Tan, Xiaoqin, Xiong, Zhaoping, Liu, Jia, Tan, Minjia, Xu, Yechun, Geng, Meiyu, Jiang, Hualiang, Liu, Hong, Ai, Jing, Zheng, Mingyue, 2019
The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design, Wu Xiaowei, 2019
Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes, Dai, Wenhao, Wu, Xiaowei, Li, Chunpu, Zhang, Rui, Wang, Jiang, Liu, Hong, 2018
Rhodium(III)-catalyzed C-H allylation of indoles with allyl alcohols via beta-hydroxide elimination, Wu, Xiaowei, Ji, Haitao, 2018
先导化合物结构优化策略（六）——改善化合物血浆稳定性, 吴小伟, 王江, 柳红, 2018
Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols, Wu, Xiaowei, Ji, Haitao, 2018
Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis, Wu Xiaowei, 2018
Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon, Wu Xiaowei, 2017
Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon, Wu, Xiaowei, Wang, Bao, Zhou, Yu, Liu, Hong, 2017

药物化学有机合成小分子药物抗肿瘤抗病毒合成方法学药理活性共价抑制剂催化杂环

戴辉雄 - 中国科学院大学

Area of Focus
药物化学 | 有机化学 | 催化 | C-H 活化 | C-C 键活化 | 钯催化 | 铜催化 | 铑催化 | 合成 | 官能化

梁箫 - 中国科学院大学

Area of Focus
天然产物 | 合成 | 化学 | 有机化学 | 不对称合成 | 生物活性化合物 | 药物化学 | 催化 | 全合成 | 生物碱

罗爽 - 中国科学院大学

Area of Focus
药物化学 | 有机合成 | 催化 | 钯 | 不对称反应 | 环化 | 杂环 | 羰基化 | 亚胺基化 | 手性化合物

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