吴小伟
Medical School
中国科学院大学
广东
Language: 中文, 英语
Contact
药物化学 有机合成 小分子药物 抗肿瘤 抗病毒 合成方法学 药理活性 共价抑制剂 催化 杂环
Areas of Focus
  • 药物化学
  • 有机合成
Work Experience
  • 2018-06~2021-02 - 贝勒医学院 - 博士后
  • 2017-08~2018-06 - H. Lee Moffitt癌症中心和研究所 - 博士后
Academic Background & Achievements
  • 2012-09--2017-07 博士: 中国科学院上海药物研究所
  • 2008-09--2012-06 学士: 四川大学
Publications
  • Design, synthesis and biological evaluation of pyrazolo3,4-dpyridazinone derivatives as covalent FGFR inhibitors, Xiaowei Wu, Mengdi Dai, Rongrong Cui, Yulan Wang, Chunpu Li, Xia Peng, Jihui Zhao, Bao Wang, Yang Dai, Dan Feng, Tianbiao Yang, Hualiang Jiang, Meiyu Geng, Jing Ai, Mingyue Zheng, Hong Liu, 2021
  • Additive-Controlled Divergent Synthesis of Tetrasubstituted 1,3-Enynes and Alkynylated 3H-Pyrrolo1,2-aindol-3-ones via Rhodium Catalysis, Zhao, Fei, Gong, Xin, Lu, Yangbin, Qiao, Jin, Jia, Xiuwen, Ni, Hangcheng, Wu, Xiaowei, Zhang, Xiaoning, 2021
  • Design, Synthesis and pharmacological evaluation of pyrazolo[3,4-d]pyridazinone derivatives as covalent FGFR inhibitors, Wu Xiaowei, 2021
  • Rhodium(III)-Catalyzed C-H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes, Wu, Xiaowei, Lu, Yangbin, Qiao, Jin, Dai, Wenhao, Jia, Xiuwen, Ni, Hangcheng, Zhang, Xiaoning, Liu, Hong, Zhao, Fei, 2020
  • Ruthenium-Catalyzed C–H Allylation of Alkenes with Allyl Alcohols via C–H Bond Activation in Aqueous Solution, Wu Xiaowei, Haitao Ji, 2020
  • Synthesis of Indole-Fused Polyheterocycles via Rh(III)-Catalyzed Regioselective [4+2] Annulation/Lactonization of Indoles with 4-Hydroxy-2-Alkynoates, Wu Xiaowei, 2020
  • Discovery and Development of a Series of Pyrazolo3,4-dpyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design, Wang, Yulan, Dai, Yang, Wu, Xiaowei, Li, Fei, Liu, Bo, Li, Chunpu, Liu, Qiufeng, Zhou, Yuanyang, Wang, Bao, Zhu, Mingrui, Cui, Rongrong, Tan, Xiaoqin, Xiong, Zhaoping, Liu, Jia, Tan, Minjia, Xu, Yechun, Geng, Meiyu, Jiang, Hualiang, Liu, Hong, Ai, Jing, Zheng, Mingyue, 2019
  • The Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as Novel Covalent FGFR Inhibitors by Rational Drug Design, Wu Xiaowei, 2019
  • Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes, Dai, Wenhao, Wu, Xiaowei, Li, Chunpu, Zhang, Rui, Wang, Jiang, Liu, Hong, 2018
  • Rhodium(III)-catalyzed C-H allylation of indoles with allyl alcohols via beta-hydroxide elimination, Wu, Xiaowei, Ji, Haitao, 2018
  • 先导化合物结构优化策略(六)——改善化合物血浆稳定性, 吴小伟, 王江, 柳红, 2018
  • Ruthenium(II)-Catalyzed Regio- and Stereoselective C-H Allylation of Indoles with Allyl Alcohols, Wu, Xiaowei, Ji, Haitao, 2018
  • Rhodium-Catalyzed [4 + 1] Cyclization via C-H Activation for Divergent Heterocycle Bearing a Quaternary Carbon Synthesis, Wu Xiaowei, 2018
  • Propargyl alcohols as one-carbon synthons: redox-neutral Rh (III)-catalyzed C-H bond activation for the synthesis of isoindolinones bearing a quaternary carbon, Wu Xiaowei, 2017
  • Propargyl Alcohols as One-Carbon Synthons: Redox-Neutral Rhodium(III)-Catalyzed C-H Bond Activation for the Synthesis of Isoindolinones Bearing a Quaternary Carbon, Wu, Xiaowei, Wang, Bao, Zhou, Yu, Liu, Hong, 2017
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