Professor | Jinxin Xu | Asia Growth Partners

Name	Jinxin Xu
Contact Information	xu_jinxin@gibh.ac.cn
Language ability	Chinese, English
Province	Guangdong

Name

Jinxin Xu

Contact Information

xu_jinxin@gibh.ac.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2006-09--2012-06 PhD: University of Science and Technology of China 2002-09--2006-06 Bachelor's: Jiangxi Normal University
Work Experience	2024-04~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2017-01~2024-04 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher 2012-07~2016-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2006-09--2012-06 PhD: University of Science and Technology of China
2002-09--2006-06 Bachelor's: Jiangxi Normal University

Work Experience

2024-04~Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2017-01~2024-04 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Associate Researcher
2012-07~2016-12 - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Assistant Researcher

Areas of Focus	Mechanisms of epigenetic regulatory factors in development and cancer Mechanisms of vesicle transport and signal transduction regulation
Publications	Biochemical and Biophysical Research Communicationsnull, Not mentioned, 2023 Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins, Yulong Zhang, Rui Chen, Yan Dong, Jiabin Zhu, Kai Su, Jinsong Liu, Jinxin Xu, 2022 Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2, Jinxin Xu, Xin Jiang, Yulong Zhang, Yan Dong, Changli Ma, Hanqiu Jiang, Taisen Zuo, Rui Chen, Yubin Ke, He Cheng, Howard Wang, Jinsong Liu, 2022 Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist, Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu, 2021 Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition, Jinxin Xu, Xiaowen Tang, Yiguang Zhu, Zhijun Yu, Kai Su, Yulong Zhang, Yan Dong, Weiming Zhu, Changsheng Zhang, Ruibo Wu, Jinsong Liu, 2020 DDX24 Mutations Associated With Malformations of Major Vessels to the Viscera, Pengfei Pang, Xiaojun Hu, Bin Zhou, Junjie Mao, Yu Liang, Zaibo Jiang, Mingsheng Huang, Ruihong Liu, Youyong Zhang, Jiesheng Qian, Jinsong Liu, Jinxin Xu, Yaqin Zhang, Maoheng Zu, Yiming Wang, Huanhuan He, Hong Shan, 2019 Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer, Yan Zhang, Xishan Wu, Xiaoqian Xue, Chenchang Li, Junjian Wang, Rui Wang, Cheng Zhang, Chao Wang, Yudan Shi, Lingjiao Zou, Qiu Li, Zenghong Huang, Xiaojuan Hao, Kerry Loomes, Donghai Wu, HongWu Chen, Jinxin Xu, Yong Xu, 2019 Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding, Na Wang, Qingan Zou, Jinxin Xu, Jiancun Zhang, Jinsong Liu, 2018 SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding, Jinxin Xu, Leilei Zhang, Yinghua Ye, Yongli Shan, Chanjuan Wan, Junfeng Wang, Duanqing Pei, Xiaodong Shu, Jinsong Liu, 2017 Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain, Kai Su, Tingting Xu, Zhijun Yu, Jiabin Zhu, Yulong Zhang, Minhao Wu, Ying Xiong, Jinsong Liu, Jinxin Xu, 2017 Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE, Shulin Hou, Tingting Xu, Jinxin Xu, Linbing Qu, Yong Xu, Ling Chen, Jinsong Liu, 2017 Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943, You Wu, Tingting Xu, Jinsong Liu, Ke Ding, Jinxin Xu, 2017 Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis, Yiguang Zhu, Jinxin Xu, Xiangui Mei, Zhan Feng, Liping Zhang, Qingbo Zhang, Guangtao Zhang, Weiming Zhu, Jinsong Liu, Changsheng Zhang, 2016 Structure of product-bound SMG1 lipase: active site gating implications, Shaohua Guo, Jinxin Xu, Ioannis V Pavlidis, Dongming Lan, Uwe T Bornscheuer, Jinsong Liu, Yonghua Wang, 2015 Structure of Sorting Nexin 11 (SNX11) Reveals a Novel Extended Phox Homology (PX) Domain Critical for Inhibition of SNX10-induced Vacuolation, Jinxin Xu, Tingting Xu, Bin Wu, Yinghua Ye, Xiaojuan You, Xiaodong Shu, Duanqing Pei, Jinsong Liu, 2012

Areas of Focus

Mechanisms of epigenetic regulatory factors in development and cancer
Mechanisms of vesicle transport and signal transduction regulation

Publications

Biochemical and Biophysical Research Communicationsnull, Not mentioned, 2023
Structural Studies Reveal Unique Non-canonical Regulators of G Protein Signaling Homology (RH) Domains in Sorting Nexins, Yulong Zhang, Rui Chen, Yan Dong, Jiabin Zhu, Kai Su, Jinsong Liu, Jinxin Xu, 2022
Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2, Jinxin Xu, Xin Jiang, Yulong Zhang, Yan Dong, Changli Ma, Hanqiu Jiang, Taisen Zuo, Rui Chen, Yubin Ke, He Cheng, Howard Wang, Jinsong Liu, 2022
Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist, Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu, 2021
Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition, Jinxin Xu, Xiaowen Tang, Yiguang Zhu, Zhijun Yu, Kai Su, Yulong Zhang, Yan Dong, Weiming Zhu, Changsheng Zhang, Ruibo Wu, Jinsong Liu, 2020
DDX24 Mutations Associated With Malformations of Major Vessels to the Viscera, Pengfei Pang, Xiaojun Hu, Bin Zhou, Junjie Mao, Yu Liang, Zaibo Jiang, Mingsheng Huang, Ruihong Liu, Youyong Zhang, Jiesheng Qian, Jinsong Liu, Jinxin Xu, Yaqin Zhang, Maoheng Zu, Yiming Wang, Huanhuan He, Hong Shan, 2019
Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer, Yan Zhang, Xishan Wu, Xiaoqian Xue, Chenchang Li, Junjian Wang, Rui Wang, Cheng Zhang, Chao Wang, Yudan Shi, Lingjiao Zou, Qiu Li, Zenghong Huang, Xiaojuan Hao, Kerry Loomes, Donghai Wu, HongWu Chen, Jinxin Xu, Yong Xu, 2019
Ligand binding and heterodimerization with retinoid X receptor α (RXRα) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding, Na Wang, Qingan Zou, Jinxin Xu, Jiancun Zhang, Jinsong Liu, 2018
SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding, Jinxin Xu, Leilei Zhang, Yinghua Ye, Yongli Shan, Chanjuan Wan, Junfeng Wang, Duanqing Pei, Xiaodong Shu, Jinsong Liu, 2017
Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain, Kai Su, Tingting Xu, Zhijun Yu, Jiabin Zhu, Yulong Zhang, Minhao Wu, Ying Xiong, Jinsong Liu, Jinxin Xu, 2017
Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE, Shulin Hou, Tingting Xu, Jinxin Xu, Linbing Qu, Yong Xu, Ling Chen, Jinsong Liu, 2017
Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943, You Wu, Tingting Xu, Jinsong Liu, Ke Ding, Jinxin Xu, 2017
Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin Biosynthesis, Yiguang Zhu, Jinxin Xu, Xiangui Mei, Zhan Feng, Liping Zhang, Qingbo Zhang, Guangtao Zhang, Weiming Zhu, Jinsong Liu, Changsheng Zhang, 2016
Structure of product-bound SMG1 lipase: active site gating implications, Shaohua Guo, Jinxin Xu, Ioannis V Pavlidis, Dongming Lan, Uwe T Bornscheuer, Jinsong Liu, Yonghua Wang, 2015
Structure of Sorting Nexin 11 (SNX11) Reveals a Novel Extended Phox Homology (PX) Domain Critical for Inhibition of SNX10-induced Vacuolation, Jinxin Xu, Tingting Xu, Bin Wu, Yinghua Ye, Xiaojuan You, Xiaodong Shu, Duanqing Pei, Jinsong Liu, 2012

Epigenetics Regulation Development Cancer Mechanisms Vesicle Transport Signal Transduction Biomolecules Disease Therapy

Hao Chen - Southern University of Science and Technology

Jun Che - Southern University of Science and Technology

Yuliang Feng - Southern University of Science and Technology

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