Professor | Jiancun Zhang | Asia Growth Partners

Name	Jiancun Zhang
Contact Information	zhang_jiancun@gibh.ac.cn
Language ability	English, Chinese
Province	Guangdong

Name

Jiancun Zhang

Contact Information

zhang_jiancun@gibh.ac.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	1985-09 to 1989-08 PhD: University of Pittsburgh 1984-09 to 1985-05 English Training: Sun Yat-sen University 1980-09 to 1984-07 Bachelor's: Fudan University
Work Experience	2005-01 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher 2002-01 to 2003-12 - Tsinghua Yuanxing Biopharmaceutical Technology - Chief Scientific Officer/Vice President 2002-01 to 2004-12 - Shanghai Jiao Tong University - Professor 1992-09 to 2001-12 - Gilead Sciences - Senior Scientist/Project Leader 1990-09 to 1992-08 - Duke University - Postdoctoral Researcher

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

1985-09 to 1989-08 PhD: University of Pittsburgh
1984-09 to 1985-05 English Training: Sun Yat-sen University
1980-09 to 1984-07 Bachelor's: Fudan University

Work Experience

2005-01 to Present - Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences - Researcher
2002-01 to 2003-12 - Tsinghua Yuanxing Biopharmaceutical Technology - Chief Scientific Officer/Vice President
2002-01 to 2004-12 - Shanghai Jiao Tong University - Professor
1992-09 to 2001-12 - Gilead Sciences - Senior Scientist/Project Leader
1990-09 to 1992-08 - Duke University - Postdoctoral Researcher

Areas of Focus	Targeted Antitumor Drugs Nucleoside Antiviral Drugs Total Synthesis of Antitumor Natural Products
Publications	Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents, Jiancun Zhang, 2016 Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy, Jiancun Zhang, 2016 Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs, Jiancun Zhang, 2016 Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for ‘two-in-one’ cancer chemoimmunotherapeutics, Jiancun Zhang, 2015 Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors., Jiancun Zhang, 2015 Syntheses of Indolizidine Alkaloids from Cascade Cross-Coupling of gem-Dibromoolefins, Jiancun Zhang, 2014 Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl Substituted Aromatic N-Heterocycles, Jiancun Zhang, 2011 A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamides in PEG-400, Jiancun Zhang, 2011 Practical one-pot protocol for the syntheses of 2-chloro-pyrrolo[3,2-d]pyrimidines, Jiancun Zhang, 2011 A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines, Jiancun Zhang, 2010 N,N -Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds, Jiancun Zhang, 2010 Facile synthesis of 2-bromoindoles by ligandfree CuI-catalyzed intramolecular crosscoupling of gem- dibromoolefins, Jiancun Zhang, 2010 A Formal Total Synthesis of Fostriecin by a Convergent Approach, Jiancun Zhang, 2010 Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity, Jiancun Zhang, 2010 Facile synthesis of benzoxazoles from 1,1-dibromoethenes, Jiancun Zhang, 2010 Highly stereoselective synthesis of 20-deoxy-b-ribonucleosides via a 3’-(N-acetyl)-glycyl- directing group, Jiancun Zhang, 2010

Areas of Focus

Targeted Antitumor Drugs
Nucleoside Antiviral Drugs
Total Synthesis of Antitumor Natural Products

Publications

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents, Jiancun Zhang, 2016
Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy, Jiancun Zhang, 2016
Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs, Jiancun Zhang, 2016
Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for ‘two-in-one’ cancer chemoimmunotherapeutics, Jiancun Zhang, 2015
Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors., Jiancun Zhang, 2015
Syntheses of Indolizidine Alkaloids from Cascade Cross-Coupling of gem-Dibromoolefins, Jiancun Zhang, 2014
Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl Substituted Aromatic N-Heterocycles, Jiancun Zhang, 2011
A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamides in PEG-400, Jiancun Zhang, 2011
Practical one-pot protocol for the syntheses of 2-chloro-pyrrolo[3,2-d]pyrimidines, Jiancun Zhang, 2011
A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines, Jiancun Zhang, 2010
N,N -Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds, Jiancun Zhang, 2010
Facile synthesis of 2-bromoindoles by ligandfree CuI-catalyzed intramolecular crosscoupling of gem- dibromoolefins, Jiancun Zhang, 2010
A Formal Total Synthesis of Fostriecin by a Convergent Approach, Jiancun Zhang, 2010
Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity, Jiancun Zhang, 2010
Facile synthesis of benzoxazoles from 1,1-dibromoethenes, Jiancun Zhang, 2010
Highly stereoselective synthesis of 20-deoxy-b-ribonucleosides via a 3’-(N-acetyl)-glycyl- directing group, Jiancun Zhang, 2010

Antitumor Targeted Therapy Drug Development Nucleoside Antiviral Natural Products Total Synthesis Cancer Chemotherapy Pharmacology

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Haibing Zhou - Wuhan University

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