Professor | 张健存 | 数字化转型顾问

Name	张健存
Contact Information	zhang_jiancun@gibh.ac.cn
Language ability	英语, 中文
Province	广东

Name

张健存

Contact Information

zhang_jiancun@gibh.ac.cn

Language ability

英语, 中文

Province

广东

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	1985-09 至 1989-08 博士: 匹兹堡大学 1984-09 至 1985-05 英语培训: 中山大学 1980-09 至 1984-07 学士: 复旦大学
Work Experience	2005-01 至今 - 中国科学院广州生物医药与健康研究院 - 研究员 2002-01 至 2003-12 - 清华源兴生物医药科技 - 首席科学官/副总裁 2002-01 至 2004-12 - 上海交通大学 - 教授 1992-09 至 2001-12 - Gilead Sciences - 资深科学家/项目领导人 1990-09 至 1992-08 - 杜克大学 - 博士后

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

1985-09 至 1989-08 博士: 匹兹堡大学
1984-09 至 1985-05 英语培训: 中山大学
1980-09 至 1984-07 学士: 复旦大学

Work Experience

2005-01 至今 - 中国科学院广州生物医药与健康研究院 - 研究员
2002-01 至 2003-12 - 清华源兴生物医药科技 - 首席科学官/副总裁
2002-01 至 2004-12 - 上海交通大学 - 教授
1992-09 至 2001-12 - Gilead Sciences - 资深科学家/项目领导人
1990-09 至 1992-08 - 杜克大学 - 博士后

Areas of Focus	靶向抗肿瘤药物核苷类抗病毒药物抗肿瘤天然产物全合成
Publications	Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents, 张健存, 2016 Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy, 张健存, 2016 Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs, 张健存, 2016 Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for ‘two-in-one’ cancer chemoimmunotherapeutics, 张健存, 2015 Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors., 张健存, 2015 Syntheses of Indolizidine Alkaloids from Cascade Cross-Coupling of gem-Dibromoolefins, 张健存, 2014 Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl Substituted Aromatic N-Heterocycles, 张健存, 2011 A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamides in PEG-400, 张健存, 2011 Practical one-pot protocol for the syntheses of 2-chloro-pyrrolo[3,2-d]pyrimidines, 张健存, 2011 A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines, 张健存, 2010 N,N -Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds, 张健存, 2010 Facile synthesis of 2-bromoindoles by ligandfree CuI-catalyzed intramolecular crosscoupling of gem- dibromoolefins, 张健存, 2010 A Formal Total Synthesis of Fostriecin by a Convergent Approach, 张健存, 2010 Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity, 张健存, 2010 Facile synthesis of benzoxazoles from 1,1-dibromoethenes, 张健存, 2010 Highly stereoselective synthesis of 20-deoxy-b-ribonucleosides via a 3’-(N-acetyl)-glycyl- directing group, 张健存, 2010

Areas of Focus

靶向抗肿瘤药物
核苷类抗病毒药物
抗肿瘤天然产物全合成

Publications

Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents, 张健存, 2016
Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy, 张健存, 2016
Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs, 张健存, 2016
Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for ‘two-in-one’ cancer chemoimmunotherapeutics, 张健存, 2015
Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors., 张健存, 2015
Syntheses of Indolizidine Alkaloids from Cascade Cross-Coupling of gem-Dibromoolefins, 张健存, 2014
Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl Substituted Aromatic N-Heterocycles, 张健存, 2011
A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamides in PEG-400, 张健存, 2011
Practical one-pot protocol for the syntheses of 2-chloro-pyrrolo[3,2-d]pyrimidines, 张健存, 2011
A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines, 张健存, 2010
N,N -Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds, 张健存, 2010
Facile synthesis of 2-bromoindoles by ligandfree CuI-catalyzed intramolecular crosscoupling of gem- dibromoolefins, 张健存, 2010
A Formal Total Synthesis of Fostriecin by a Convergent Approach, 张健存, 2010
Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity, 张健存, 2010
Facile synthesis of benzoxazoles from 1,1-dibromoethenes, 张健存, 2010
Highly stereoselective synthesis of 20-deoxy-b-ribonucleosides via a 3’-(N-acetyl)-glycyl- directing group, 张健存, 2010

抗肿瘤靶向治疗药物开发核苷抗病毒天然产物全合成癌症化疗药理学

梁箫 - 中国科学院大学

Area of Focus
天然产物 | 合成 | 化学 | 有机化学 | 不对称合成 | 生物活性化合物 | 药物化学 | 催化 | 全合成 | 生物碱

汪亮亮 - 中国科学院大学

王杰 - 中国科学院大学

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们