Areas of Focus
- 靶向抗肿瘤药物
- 核苷类抗病毒药物
- 抗肿瘤天然产物全合成
Work Experience
- 2005-01 至 今 - 中国科学院广州生物医药与健康研究院 - 研究员
- 2002-01 至 2003-12 - 清华源兴生物医药科技 - 首席科学官/副总裁
- 2002-01 至 2004-12 - 上海交通大学 - 教授
- 1992-09 至 2001-12 - Gilead Sciences - 资深科学家/项目领导人
- 1990-09 至 1992-08 - 杜克大学 - 博士后
Academic Background & Achievements
- 1985-09 至 1989-08 博士: 匹兹堡大学
- 1984-09 至 1985-05 英语培训: 中山大学
- 1980-09 至 1984-07 学士: 复旦大学
Publications
- Design, synthesis, and in vitro biological evaluation of novel 6-methyl-7-substituted-7-deaza purine nucleoside analogs as anti-influenza A agents, 张健存, 2016
- Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy, 张健存, 2016
- Synthesis and Evaluation of 2'-Deoxy-2'-Spirodiflurocyclopropyl Nucleoside Analogs, 张健存, 2016
- Dichotomous role of protein kinase A type I (PKAI) in the tumor microenvironment: A potential target for ‘two-in-one’ cancer chemoimmunotherapeutics, 张健存, 2015
- Synthesis and biological evaluation of 3,5-disubstituted-4-alkynylisoxozales as a novel class of HSP90 inhibitors., 张健存, 2015
- Syntheses of Indolizidine Alkaloids from Cascade Cross-Coupling of gem-Dibromoolefins, 张健存, 2014
- Copper-Catalyzed Intramolecular Dehydrogenative Aminooxygenation: Direct Access to Formyl Substituted Aromatic N-Heterocycles, 张健存, 2011
- A Practical Synthesis of 2-Aroylindoles from N-(2-Formylphenyl)trifluoroacetamides in PEG-400, 张健存, 2011
- Practical one-pot protocol for the syntheses of 2-chloro-pyrrolo[3,2-d]pyrimidines, 张健存, 2011
- A Direct Intramolecular C-H Amination Reaction Cocatalyzed by Copper(II) and Iron(III) as Part of an Efficient Route for the Synthesis of Pyrido[1,2-a]benzimidazoles from N-Aryl-2-aminopyridines, 张健存, 2010
- N,N -Di-Boc-Substituted Thiourea as a Novel and Mild Thioacylating Agent Applicable for the Synthesis of Thiocarbonyl Compounds, 张健存, 2010
- Facile synthesis of 2-bromoindoles by ligandfree CuI-catalyzed intramolecular crosscoupling of gem- dibromoolefins, 张健存, 2010
- A Formal Total Synthesis of Fostriecin by a Convergent Approach, 张健存, 2010
- Dimerization of CPAP Orchestrates Centrosome Cohesion Plasticity, 张健存, 2010
- Facile synthesis of benzoxazoles from 1,1-dibromoethenes, 张健存, 2010
- Highly stereoselective synthesis of 20-deoxy-b-ribonucleosides via a 3’-(N-acetyl)-glycyl- directing group, 张健存, 2010
