Areas of Focus
- Structural Pharmacology
- GPCR Target Structure and Function Research
- Targeted Drug Development
Work Experience
- 2012-09--2016-06 - East China Normal University - PhD Student
- 2010-10--2011-04 - Van Andel Research Institute, USA - Visiting Scholar
- 2010-07--Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher
- 2008-07--2010-06 - Shanghai Institute of Health Sciences, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2012-09--2016-06 PhD: East China Normal University
Publications
- Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., Lihua Zhao, 2024
- Conserved class B GPCR activation by a biased intracellular agonist, Lihua Zhao, 2023
- Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, Lihua Zhao, 2023
- Structural insights into multiplexed pharmacological actions of the GIP, GLP-1 and glucagon receptors., Lihua Zhao, 2022
- Structure Insights into Selective Coupling of G Protein Subtypes by a Class B G Protein-Coupled Receptor., Lihua Zhao, 2022
- Constitutive signal bias mediated by the human GHRHR splice variant 1, Lihua Zhao, 2021
- Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, Lihua Zhao, 2021
- Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor., Lihua Zhao, 2021
- Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2., Lihua Zhao, 2021
- Structural insights into the activation of GLP-1R by a small molecule agonist, Lihua Zhao, 2020
- Structural basis for activation of the growth hormone-releasing hormone receptor, Lihua Zhao, 2020
- A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, Lihua Zhao, 2020
- Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors, Lihua Zhao, 2020
- Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., Lihua Zhao, 2020
- Structure and dynamics of the active human parathyroid hormone receptor-1, Lihua Zhao, 2019
- The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine, Lihua Zhao, 2018
- Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, Lihua Zhao, 2017
- Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors, Lihua Zhao, 2016
- An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, Lihua Zhao, 2016
- Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, Lihua Zhao, 2015
- DWARF 53 acts as a repressor of strigolactone signalling in rice, Lihua Zhao, 2013
- Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, Lihua Zhao, 2013
Awards
- Chinese Academy of Sciences Innovation Promotion Association Outstanding Member (2022): First Prize, Institute Level
- Oriental Talent Plan Youth Project (2022): First Prize, Provincial Level
- Sanofi-Youth Talent Award (2017): First Prize, Institute Level
- Chinese Academy of Sciences Youth Innovation Promotion Association (2017): First Prize, Institute Level
