Professor | Lihua Zhao | Asia Growth Partners

Name	Lihua Zhao
Contact Information	zhaolihuawendy@simm.ac.cn
Language ability	Chinese, English
Province	Shanghai

Name

Lihua Zhao

Contact Information

zhaolihuawendy@simm.ac.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Medical School
Academic Background & Achievements	2012-09--2016-06 PhD: East China Normal University
Work Experience	2012-09--2016-06 - East China Normal University - PhD Student 2010-10--2011-04 - Van Andel Research Institute, USA - Visiting Scholar 2010-07--Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher 2008-07--2010-06 - Shanghai Institute of Health Sciences, Chinese Academy of Sciences - Assistant Researcher
Awards	Chinese Academy of Sciences Innovation Promotion Association Outstanding Member (2022): First Prize, Institute Level Oriental Talent Plan Youth Project (2022): First Prize, Provincial Level Sanofi-Youth Talent Award (2017): First Prize, Institute Level Chinese Academy of Sciences Youth Innovation Promotion Association (2017): First Prize, Institute Level

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Medical School

Academic Background & Achievements

2012-09--2016-06 PhD: East China Normal University

Work Experience

2012-09--2016-06 - East China Normal University - PhD Student
2010-10--2011-04 - Van Andel Research Institute, USA - Visiting Scholar
2010-07--Present - Shanghai Institute of Materia Medica, Chinese Academy of Sciences - Assistant Researcher, Associate Researcher
2008-07--2010-06 - Shanghai Institute of Health Sciences, Chinese Academy of Sciences - Assistant Researcher

Awards

Chinese Academy of Sciences Innovation Promotion Association Outstanding Member (2022): First Prize, Institute Level
Oriental Talent Plan Youth Project (2022): First Prize, Provincial Level
Sanofi-Youth Talent Award (2017): First Prize, Institute Level
Chinese Academy of Sciences Youth Innovation Promotion Association (2017): First Prize, Institute Level

Areas of Focus	Structural Pharmacology GPCR Target Structure and Function Research Targeted Drug Development
Publications	Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., Lihua Zhao, 2024 Conserved class B GPCR activation by a biased intracellular agonist, Lihua Zhao, 2023 Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, Lihua Zhao, 2023 Structural insights into multiplexed pharmacological actions of the GIP, GLP-1 and glucagon receptors., Lihua Zhao, 2022 Structure Insights into Selective Coupling of G Protein Subtypes by a Class B G Protein-Coupled Receptor., Lihua Zhao, 2022 Constitutive signal bias mediated by the human GHRHR splice variant 1, Lihua Zhao, 2021 Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, Lihua Zhao, 2021 Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor., Lihua Zhao, 2021 Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2., Lihua Zhao, 2021 Structural insights into the activation of GLP-1R by a small molecule agonist, Lihua Zhao, 2020 Structural basis for activation of the growth hormone-releasing hormone receptor, Lihua Zhao, 2020 A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, Lihua Zhao, 2020 Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors, Lihua Zhao, 2020 Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., Lihua Zhao, 2020 Structure and dynamics of the active human parathyroid hormone receptor-1, Lihua Zhao, 2019 The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine, Lihua Zhao, 2018 Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, Lihua Zhao, 2017 Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors, Lihua Zhao, 2016 An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, Lihua Zhao, 2016 Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, Lihua Zhao, 2015 DWARF 53 acts as a repressor of strigolactone signalling in rice, Lihua Zhao, 2013 Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, Lihua Zhao, 2013

Areas of Focus

Structural Pharmacology
GPCR Target Structure and Function Research
Targeted Drug Development

Publications

Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., Lihua Zhao, 2024
Conserved class B GPCR activation by a biased intracellular agonist, Lihua Zhao, 2023
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, Lihua Zhao, 2023
Structural insights into multiplexed pharmacological actions of the GIP, GLP-1 and glucagon receptors., Lihua Zhao, 2022
Structure Insights into Selective Coupling of G Protein Subtypes by a Class B G Protein-Coupled Receptor., Lihua Zhao, 2022
Constitutive signal bias mediated by the human GHRHR splice variant 1, Lihua Zhao, 2021
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, Lihua Zhao, 2021
Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor., Lihua Zhao, 2021
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2., Lihua Zhao, 2021
Structural insights into the activation of GLP-1R by a small molecule agonist, Lihua Zhao, 2020
Structural basis for activation of the growth hormone-releasing hormone receptor, Lihua Zhao, 2020
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, Lihua Zhao, 2020
Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors, Lihua Zhao, 2020
Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., Lihua Zhao, 2020
Structure and dynamics of the active human parathyroid hormone receptor-1, Lihua Zhao, 2019
The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine, Lihua Zhao, 2018
Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, Lihua Zhao, 2017
Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors, Lihua Zhao, 2016
An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, Lihua Zhao, 2016
Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, Lihua Zhao, 2015
DWARF 53 acts as a repressor of strigolactone signalling in rice, Lihua Zhao, 2013
Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, Lihua Zhao, 2013

Structural Pharmacology Gpcr Target Structure Function Research Drug Development Pharmacology Receptor Ligand Activation Biased Agonist

Hui Wang - Wuhan University

Xin Liu - Wuhan University

Jianqing Yu - Wuhan University

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