Areas of Focus
- 结构药理学
- GPCR药靶结构与功能研究
- 靶向药物研发
Work Experience
- 2012-09--2016-06 - 华东师范大学 - 博士研究生
- 2010-10--2011-04 - 美国文安德研究所 - 访问学者
- 2010-07--现在 - 中国科学院上海药物研究所 - 助理研究员，副研究员
- 2008-07--2010-06 - 中科院上海健康科学研究所 - 助理研究员
Academic Background & Achievements
- 2012-09--2016-06 博士研究生: 华东师范大学
Publications
- Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., 赵丽华, 2024
- Conserved class B GPCR activation by a biased intracellular agonist, 赵丽华, 2023
- Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, 赵丽华, 2023
- Structural insights into multiplexed pharmacological actions of the GIP, GLP-1 and glucagon receptors., 赵丽华, 2022
- Structure Insights into Selective Coupling of G Protein Subtypes by a Class B G Protein-Coupled Receptor., 赵丽华, 2022
- Constitutive signal bias mediated by the human GHRHR splice variant 1, 赵丽华, 2021
- Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, 赵丽华, 2021
- Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor., 赵丽华, 2021
- Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2., 赵丽华, 2021
- Structural insights into the activation of GLP-1R by a small molecule agonist, 赵丽华, 2020
- Structural basis for activation of the growth hormone-releasing hormone receptor, 赵丽华, 2020
- A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, 赵丽华, 2020
- Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors, 赵丽华, 2020
- Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., 赵丽华, 2020
- Structure and dynamics of the active human parathyroid hormone receptor-1, 赵丽华, 2019
- The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine, 赵丽华, 2018
- Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, 赵丽华, 2017
- Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors, 赵丽华, 2016
- An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, 赵丽华, 2016
- Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, 赵丽华, 2015
- DWARF 53 acts as a repressor of strigolactone signalling in rice, 赵丽华, 2013
- Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, 赵丽华, 2013
Awards
- 中国科学院创新促进会优秀会员 (2022): 一等奖, 院级
- 东方英才计划青年项目 (2022): 一等奖, 省级
- 赛诺菲-中科院优秀青年人才奖 (2017): 一等奖, 院级
- 中科院青年创新促进会 (2017): 一等奖, 院级
