Professor | 赵丽华 | 数字化转型顾问

Name	赵丽华
Contact Information	zhaolihuawendy@simm.ac.cn
Language ability	中文, 英语
Province	上海

Name

赵丽华

Contact Information

zhaolihuawendy@simm.ac.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	中国科学院大学
Faculty	Medical School
Academic Background & Achievements	2012-09--2016-06 博士研究生: 华东师范大学
Work Experience	2012-09--2016-06 - 华东师范大学 - 博士研究生 2010-10--2011-04 - 美国文安德研究所 - 访问学者 2010-07--现在 - 中国科学院上海药物研究所 - 助理研究员，副研究员 2008-07--2010-06 - 中科院上海健康科学研究所 - 助理研究员
Awards	中国科学院创新促进会优秀会员 (2022): 一等奖, 院级东方英才计划青年项目 (2022): 一等奖, 省级赛诺菲-中科院优秀青年人才奖 (2017): 一等奖, 院级中科院青年创新促进会 (2017): 一等奖, 院级

University/Lab Affiliation and Title

中国科学院大学

Faculty

Medical School

Academic Background & Achievements

2012-09--2016-06 博士研究生: 华东师范大学

Work Experience

2012-09--2016-06 - 华东师范大学 - 博士研究生
2010-10--2011-04 - 美国文安德研究所 - 访问学者
2010-07--现在 - 中国科学院上海药物研究所 - 助理研究员，副研究员
2008-07--2010-06 - 中科院上海健康科学研究所 - 助理研究员

Awards

中国科学院创新促进会优秀会员 (2022): 一等奖, 院级
东方英才计划青年项目 (2022): 一等奖, 省级
赛诺菲-中科院优秀青年人才奖 (2017): 一等奖, 院级
中科院青年创新促进会 (2017): 一等奖, 院级

Areas of Focus	结构药理学 GPCR药靶结构与功能研究靶向药物研发
Publications	Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., 赵丽华, 2024 Conserved class B GPCR activation by a biased intracellular agonist, 赵丽华, 2023 Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, 赵丽华, 2023 Structural insights into multiplexed pharmacological actions of the GIP, GLP-1 and glucagon receptors., 赵丽华, 2022 Structure Insights into Selective Coupling of G Protein Subtypes by a Class B G Protein-Coupled Receptor., 赵丽华, 2022 Constitutive signal bias mediated by the human GHRHR splice variant 1, 赵丽华, 2021 Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, 赵丽华, 2021 Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor., 赵丽华, 2021 Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2., 赵丽华, 2021 Structural insights into the activation of GLP-1R by a small molecule agonist, 赵丽华, 2020 Structural basis for activation of the growth hormone-releasing hormone receptor, 赵丽华, 2020 A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, 赵丽华, 2020 Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors, 赵丽华, 2020 Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., 赵丽华, 2020 Structure and dynamics of the active human parathyroid hormone receptor-1, 赵丽华, 2019 The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine, 赵丽华, 2018 Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, 赵丽华, 2017 Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors, 赵丽华, 2016 An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, 赵丽华, 2016 Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, 赵丽华, 2015 DWARF 53 acts as a repressor of strigolactone signalling in rice, 赵丽华, 2013 Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, 赵丽华, 2013

Areas of Focus

结构药理学
GPCR药靶结构与功能研究
靶向药物研发

Publications

Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., 赵丽华, 2024
Conserved class B GPCR activation by a biased intracellular agonist, 赵丽华, 2023
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1, 赵丽华, 2023
Structural insights into multiplexed pharmacological actions of the GIP, GLP-1 and glucagon receptors., 赵丽华, 2022
Structure Insights into Selective Coupling of G Protein Subtypes by a Class B G Protein-Coupled Receptor., 赵丽华, 2022
Constitutive signal bias mediated by the human GHRHR splice variant 1, 赵丽华, 2021
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor, 赵丽华, 2021
Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor., 赵丽华, 2021
Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2., 赵丽华, 2021
Structural insights into the activation of GLP-1R by a small molecule agonist, 赵丽华, 2020
Structural basis for activation of the growth hormone-releasing hormone receptor, 赵丽华, 2020
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor, 赵丽华, 2020
Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors, 赵丽华, 2020
Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors., 赵丽华, 2020
Structure and dynamics of the active human parathyroid hormone receptor-1, 赵丽华, 2019
The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine, 赵丽华, 2018
Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors, 赵丽华, 2017
Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors, 赵丽华, 2016
An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain, 赵丽华, 2016
Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3, 赵丽华, 2015
DWARF 53 acts as a repressor of strigolactone signalling in rice, 赵丽华, 2013
Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14, 赵丽华, 2013

结构药理学 Gpcr 靶结构功能研究药物研发药理学受体配体激活偏向性激动剂

耿勇 - 中国科学院大学

吴蓓丽 - 中国科学院大学

Area of Focus
蛋白质 | 三维结构 | 分子 | 生物学 | 生物物理学 | 药理学 | 趋化因子 | 受体 | Gpcr | 配体

谢欣 - 中国科学院大学

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们