Professor | Qian Liu | Asia Growth Partners

Name	Qian Liu
Contact Information	liuqian1018@sjtu.edu.cn
Language ability	English, Chinese
Province	Shanghai

Name

Qian Liu

Contact Information

liuqian1018@sjtu.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	2010-2011 Exchange at UCLA, Department of Chemistry and Biomolecular Engineering, Supervisor: Yi Tang 2007-2012 PhD in Microbiology, Shanghai Jiao Tong University, Supervisor: Xiufen Zhou 2003-2007 Bachelor in Biotechnology, Shanghai Jiao Tong University Hosted national natural science funds, key R&D plan sub-projects
Work Experience	2020 - Present: Associate Researcher, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University 2015-2019: Assistant Researcher, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University 2013-2015: Postdoctoral Researcher/Assistant Researcher, School of Pharmacy, Wuhan University
Awards	2016: Shanghai Municipal Science and Technology Young Talent Sail Plan 2016: Shanghai Jiao Tong University Morning Star Young Scholar Award

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

2010-2011 Exchange at UCLA, Department of Chemistry and Biomolecular Engineering, Supervisor: Yi Tang
2007-2012 PhD in Microbiology, Shanghai Jiao Tong University, Supervisor: Xiufen Zhou
2003-2007 Bachelor in Biotechnology, Shanghai Jiao Tong University
Hosted national natural science funds, key R&D plan sub-projects

Work Experience

2020 - Present: Associate Researcher, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
2015-2019: Assistant Researcher, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University
2013-2015: Postdoctoral Researcher/Assistant Researcher, School of Pharmacy, Wuhan University

Awards

2016: Shanghai Municipal Science and Technology Young Talent Sail Plan
2016: Shanghai Jiao Tong University Morning Star Young Scholar Award

Areas of Focus	Enzymatic mechanisms and molecular design in microbial natural product biosynthesis Biological synthesis and targeted modification of microbial secondary metabolites Enzymatic mechanisms and gene detection development of microbial nucleases
Publications	Mesophilic Argonaute-based isothermal detection of SARS-CoV-2, Qian Liu, 2022 Argonaute-integrated isothermal amplification for rapid, portable, multiplex detection of SARS-CoV-2 and influenza viruses, Qian Liu, 2022 Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Qian Liu, 2022 Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Qian Liu, 2021 Utility of B‑Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Qian Liu, 2018 The state-of-the-art strategies of protein engineering for enzyme stabilization, Qian Liu, 2018 Argonaute with stepwise endonuclease activity promotes specific and multiplex nucleic acid detection, Qian Liu, 2021 Probing and Engineering the Fatty Acyl Substrate Selectivity of Starter Condensation Domains of Nonribosomal Peptide Synthetases in Lipopeptide Biosynthesis, Qian Liu, 2019 A hyperthermophilic Argonaute from Ferroglobus placidus with specificity on guide binding pattern, Qian Liu, 2021 Characterization of protein interaction surface on fatty acyl selectivity of starter condensation domain in lipopeptide biosynthesis, Qian Liu, 2019

Areas of Focus

Enzymatic mechanisms and molecular design in microbial natural product biosynthesis
Biological synthesis and targeted modification of microbial secondary metabolites
Enzymatic mechanisms and gene detection development of microbial nucleases

Publications

Mesophilic Argonaute-based isothermal detection of SARS-CoV-2, Qian Liu, 2022
Argonaute-integrated isothermal amplification for rapid, portable, multiplex detection of SARS-CoV-2 and influenza viruses, Qian Liu, 2022
Loosely-packed dynamical structures with partially-melted surface being the key for thermophilic argonaute proteins achieving high DNA-cleavage activity, Qian Liu, 2022
Argonaute integrated single-tube PCR system enables supersensitive detection of rare mutations, Qian Liu, 2021
Utility of B‑Factors in Protein Science: Interpreting Rigidity, Flexibility, and Internal Motion and Engineering Thermostability, Qian Liu, 2018
The state-of-the-art strategies of protein engineering for enzyme stabilization, Qian Liu, 2018
Argonaute with stepwise endonuclease activity promotes specific and multiplex nucleic acid detection, Qian Liu, 2021
Probing and Engineering the Fatty Acyl Substrate Selectivity of Starter Condensation Domains of Nonribosomal Peptide Synthetases in Lipopeptide Biosynthesis, Qian Liu, 2019
A hyperthermophilic Argonaute from Ferroglobus placidus with specificity on guide binding pattern, Qian Liu, 2021
Characterization of protein interaction surface on fatty acyl selectivity of starter condensation domain in lipopeptide biosynthesis, Qian Liu, 2019

Enzymes Molecular Design Biosynthesis Microbial Products Secondary Metabolites Protein Engineering Metabolic Pathways Drug Synthesis High-Value Compounds Cell Factories

Yinhua Lu - Shanghai Normal University

Jun Zhao - Shanghai Normal University

Wei Ding - Shanghai Jiao Tong University

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