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Zhijian Cai
Medical School
Zhejiang University
Zhejiang
Language: Chinese, English
Extracellular Vesicles
Tumor Immunity
Immune Tolerance
Cd19
Epcam
Dendritic Cells
Chemotherapy
Tumor Metastasis
Mucosal Immunity
Lysosomal Degradation
Areas of Focus
- Extracellular Vesicles and Tumor Immunity
- Extracellular Vesicles and Immune Tolerance
Work Experience
- 2009.1-2010.12 - Zhejiang University School of Medicine - Postdoctoral Researcher
- 2011.1-2013.12 - Zhejiang University School of Medicine, Department of Immunology - Lecturer
- 2014.1-2018.12 - Zhejiang University School of Medicine, Department of Immunology - Associate Professor
- 2018.12-Present - Zhejiang University School of Medicine, Department of Immunology - Professor
Academic Background & Achievements
- 1998.9-2003.6 Bachelor: Wenzhou Medical University
- 2003.9-2008.12 Doctorate: Zhejiang University
- Discovered CD19 positive extracellular vesicles inhibit post-chemotherapy anti-tumor immunity
- Discovered tumor cell-derived extracellular vesicles promote tumor metastasis by conditioning dendritic cells
- Developed drug-loaded extracellular vesicles for liver tumor treatment
- Discovered EpCAM positive extracellular vesicles and CD8α, CD11c positive extracellular vesicles maintain mucosal immune balance in the intestine and respiratory tract
- Discovered that coronin 1a recruits Rab7 to promote lysosomal degradation of multivesicular bodies, inhibiting extracellular vesicle secretion
