Professor | Haitian Fan | Asia Growth Partners

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Name	Haitian Fan
Contact Information	haitian.fan@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Haitian Fan

Contact Information

haitian.fan@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2001-2005: Bachelor of Science, Zhejiang University 2005-2012: Doctor of Science, University of Chinese Academy of Sciences Successfully resolved high-resolution structures of influenza A virus polymerase Identified key sites of influenza virus polymerase using nanobody technology Proposed models for influenza virus genome replication and virus-host interactions
Work Experience	2013-2015: University of California, Riverside - Postdoctoral Researcher 2016-2023: University of Oxford, Department of Pathology - Postdoctoral Researcher 2023-present: Zhejiang University, School of Basic Medical Sciences - Researcher 2023-present: Zhejiang University, The First Affiliated Hospital - Joint Researcher

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2001-2005: Bachelor of Science, Zhejiang University
2005-2012: Doctor of Science, University of Chinese Academy of Sciences
Successfully resolved high-resolution structures of influenza A virus polymerase
Identified key sites of influenza virus polymerase using nanobody technology
Proposed models for influenza virus genome replication and virus-host interactions

Work Experience

2013-2015: University of California, Riverside - Postdoctoral Researcher
2016-2023: University of Oxford, Department of Pathology - Postdoctoral Researcher
2023-present: Zhejiang University, School of Basic Medical Sciences - Researcher
2023-present: Zhejiang University, The First Affiliated Hospital - Joint Researcher

Areas of Focus	Replication mechanisms of negative-strand RNA viruses Nuclear import mechanisms of influenza virus genome Virus-host interactions
Publications	Defining the minimal components of the influenza A virus replication machinery via an in vitro reconstitution system, Zihan Zhu, Haitian Fan, Ervin Fodor, 2023 The C-terminal LCAR of host ANP32 proteins interacts with the influenza A virus nucleoprotein to promote the replication of the viral RNA genome, Fangzheng Wang, Carol Sheppard, Bhakti Mistry, Ecco Staller, Wendy Barclay, Jonathan Grimes, Ervin Fodor, Haitian Fan, 2022 The C-terminal domains of the PB2 subunit of the influenza A virus RNA polymerase directly interact with cellular GTPase Rab11a, Hana Veler, Haitian Fan, Jeremy Keown, Jane Sharps, Marjorie Fournier, Jonathan Grimes, Ervin Fodor, 2022 Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies, Jeremy Keown, Zihan Zhu, Loïc Carrique, Haitian Fan, Alexander Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan Grimes, 2022 Host ANP32A mediates the assembly of the influenza virus replicase, Löic Carrique, Haitian Fan, Alexander Walker, Jeremy Keown, Jane Sharps, Ecco Staller, Wendy Barclay, Ervin Fodor, Jonathan Grimes, 2020 Structures of influenza A virus RNA polymerase offer insight into viral genome replication, Haitian Fan, Alexander Walker, Löic Carrique, Jeremy Keown, Itziar Serna Martin, Dimple Karia, Jane Sharps, Narin Hengrung, Els Pardon, Jan Steyaert, Jonathan Grimes, Ervin Fodor, 2019 Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits, Haitian Fan, Adam Conn, Preston Williams, Stephen Diggs, Joseph Hahm, Howard Gamper Jr, Ya-ming Hou, Sean O’Leary, Yinsheng Wang, Gregor Blaha, 2017 Structural and functional analysis of BipA, a regulator of virulence in enteropathogenic Escherichia coli, Haitian Fan, Joseph Hahm, Stephen Diggs, Jefferson Perry, Gregor Blaha, 2015

Areas of Focus

Replication mechanisms of negative-strand RNA viruses
Nuclear import mechanisms of influenza virus genome
Virus-host interactions

Publications

Defining the minimal components of the influenza A virus replication machinery via an in vitro reconstitution system, Zihan Zhu, Haitian Fan, Ervin Fodor, 2023
The C-terminal LCAR of host ANP32 proteins interacts with the influenza A virus nucleoprotein to promote the replication of the viral RNA genome, Fangzheng Wang, Carol Sheppard, Bhakti Mistry, Ecco Staller, Wendy Barclay, Jonathan Grimes, Ervin Fodor, Haitian Fan, 2022
The C-terminal domains of the PB2 subunit of the influenza A virus RNA polymerase directly interact with cellular GTPase Rab11a, Hana Veler, Haitian Fan, Jeremy Keown, Jane Sharps, Marjorie Fournier, Jonathan Grimes, Ervin Fodor, 2022
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies, Jeremy Keown, Zihan Zhu, Loïc Carrique, Haitian Fan, Alexander Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan Grimes, 2022
Host ANP32A mediates the assembly of the influenza virus replicase, Löic Carrique, Haitian Fan, Alexander Walker, Jeremy Keown, Jane Sharps, Ecco Staller, Wendy Barclay, Ervin Fodor, Jonathan Grimes, 2020
Structures of influenza A virus RNA polymerase offer insight into viral genome replication, Haitian Fan, Alexander Walker, Löic Carrique, Jeremy Keown, Itziar Serna Martin, Dimple Karia, Jane Sharps, Narin Hengrung, Els Pardon, Jan Steyaert, Jonathan Grimes, Ervin Fodor, 2019
Transcription-translation coupling: direct interactions of RNA polymerase with ribosomes and ribosomal subunits, Haitian Fan, Adam Conn, Preston Williams, Stephen Diggs, Joseph Hahm, Howard Gamper Jr, Ya-ming Hou, Sean O’Leary, Yinsheng Wang, Gregor Blaha, 2017
Structural and functional analysis of BipA, a regulator of virulence in enteropathogenic Escherichia coli, Haitian Fan, Joseph Hahm, Stephen Diggs, Jefferson Perry, Gregor Blaha, 2015

Rna Viruses Replication Influenza Genome Nuclear Import Virus-Host Interactions Biochemistry Biophysics Structural Biology

Ping Liang - Zhejiang University

Jiangtao Guo - Zhejiang University

Xiaomin Yue - Zhejiang University

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