Professor | Xuanwen Bao | Asia Growth Partners

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Name	Xuanwen Bao
Contact Information	xuanwen.bao@zju.edu.cn
Language ability	Chinese, English, German
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Xuanwen Bao

Contact Information

xuanwen.bao@zju.edu.cn

Language ability

Chinese, English, German

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Medical
Academic Background & Achievements	2020 PhD: Technical University of Munich, School of Medicine Zhejiang University 'Clinical Outstanding Young Talent' cultivation target
Work Experience	2016.10-2020.07 - Helmholtz Zentrum München - Bioinformatics 2014.08-2016.06 - Institute of Chemistry and Physics, Chinese Academy of Sciences - Microfluidic Systems Research

University/Lab Affiliation and Title

Zhejiang University

Faculty

Medical

Academic Background & Achievements

2020 PhD: Technical University of Munich, School of Medicine
Zhejiang University 'Clinical Outstanding Young Talent' cultivation target

Work Experience

2016.10-2020.07 - Helmholtz Zentrum München - Bioinformatics
2014.08-2016.06 - Institute of Chemistry and Physics, Chinese Academy of Sciences - Microfluidic Systems Research

Areas of Focus	Exploring tumor spatial distribution heterogeneity based on deep learning and high-throughput omics Regulating tumor immunotherapy by targeting tumor-associated macrophages Computational Biology Bioinformatics
Publications	A Pathologically Friendly Strategy for Determining the Organ-specific Spatial Tumor Microenvironment Topology in Lung Adenocarcinoma through the Integration of snRandom-seq and Imaging Mass Cytometry, XQ Sun+, X Teng+, C Liu+, ... Y Shi, & XW Bao, 2024 Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy, C Liu+, JD Xie+, B Lin+, ... XW Bao, & Zhao P, 2024 A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer, XW Bao+, Li Q+, Chen D+, et al., 2024 A novel molecular subtyping based on multi-omics analysis for prognosis predicting in colorectal melanoma: A 16-year prospective multicentric study, C Liu+, XF Cheng+, K Han+, ... XW Bao, & Zhao P, D Chen, 2024 Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel, Dai XM, J Zhang, XW Bao, et al., 2023 An immunometabolism subtyping system identifies S100A9+ macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis, Bao X, Wang DY, Dai XM, et al., 2023 Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing-Assisted Multi-Omics Analysis, Bao X, Li Q, Chen J, et al., 2022 MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling, Xin, S., Mueller, C., Pfeiffer, S., Kraft, V. A., Merl-Pham, J., Bao, X., ... & Schick, J. A., 2022 Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy, Bao X, Zhang H, Wu W, et al., 2020 Development and validation of a meta-learning-based multi-modal deep learning algorithm for detection of peritoneal metastasis, Zhang H, Zhu X, Li B, et al., 2022 Construction of TME and identification of crosstalk between malignant cells and macrophages by SPP1 in hepatocellular carcinoma, Liu, L., Zhang, R., Deng, J., Dai, X., Zhu, X., Fu, Q., ... & Bao, X., 2022 Enhanced radiotherapy efficacy and induced anti-tumor immunity in HCC by improving hypoxia microenvironment using oxygen microcapsules, Dai, X., Ruan, J., Guo, Y., Sun, Z., Liu, J., Bao, X., ... & Zhao, P., 2021 Depiction of the genomic and genetic landscape identifies CCL5 as a protective factor in colorectal neuroendocrine carcinoma, Chen, D., Bao, X., Zhang, R., Ding, Y., Zhang, M., Li, B., ... & Zhao, P., 2021 Characterization of Genomic Alterations in Colorectal Liver Metastasis and Their Prognostic Value, Bao, X., Wang, K., Liu, M., Li, B., Wang, H., Jin, K., ... & Xing, B., 2021 Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients, Shi, R., Bao, X., Unger, K., Sun, J., Lu, S., Manapov, F., ... & Li, M., 2021 Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and aggressiveness in TNBC, Bao, X., Shi, R., Zhao, T., Wang, Y., Anastasov, N., Rosemann, M., & Fang, W., 2021 Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1, Yang, L., Kraft, V. A., Pfeiffer, S., Merl‐Pham, J., Bao, X., An, Y., ... & Schick, J. A., 2020 Tumor microenvironment characterization in head and neck squamous carcinoma reveals distinct genomic alterations and clinical outcomes, Shi R, Bao X, Sun J, et al., 2020 Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1‐related genes and impairs DNA double‐strand break recognition, Bao X, Wang J, Zhou G, et al., 2020 Establishment and validation of an individualized cell cycle process-related gene signature to predict cancer-specific survival in patients with bladder cancer, Shi R, Bao X, Rogowski P, et al., 2020 Mast cell‐based molecular subtypes and signature associated with clinical outcome in early‐stage lung adenocarcinoma, Bao X, Shi R, Zhao T, et al., 2020 GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling, Kraft V A N, Bezjian C T, Pfeiffer S, et al., 2019 A novel gene signature-based model predicts biochemical recurrence-free survival in prostate cancer patients after radical prostatectomy, Shi R, Bao X, Weischenfeldt J, et al., 2019 Development of a membrane lipid metabolism–based signature to predict overall survival for personalized medicine in ccRCC patients, Bao M, Shi R, Zhang K, Bao X., 2019 Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability, Hladik, D., Höfig, I., Oestreicher, U., Beckers, J., Matjanovski, M., Bao, X., ... & Rosemann, M., 2019 A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis, Wang, Y., Zhang, Q., Gao, Z., Xin, S., Zhao, Y., Zhang, K., ... & Bao, X., 2019 A novel epigenetic signature for overall survival prediction in patients with breast cancer, Bao, X., Anastasov, N., Wang, Y., & Rosemann, M., 2019

Areas of Focus

Exploring tumor spatial distribution heterogeneity based on deep learning and high-throughput omics
Regulating tumor immunotherapy by targeting tumor-associated macrophages
Computational Biology
Bioinformatics

Publications

A Pathologically Friendly Strategy for Determining the Organ-specific Spatial Tumor Microenvironment Topology in Lung Adenocarcinoma through the Integration of snRandom-seq and Imaging Mass Cytometry, XQ Sun+, X Teng+, C Liu+, ... Y Shi*, & XW Bao*, 2024
Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy, C Liu+, JD Xie+, B Lin+, ... XW Bao*, & Zhao P*, 2024
A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer, XW Bao+*, Li Q+, Chen D+, et al., 2024
A novel molecular subtyping based on multi-omics analysis for prognosis predicting in colorectal melanoma: A 16-year prospective multicentric study, C Liu+, XF Cheng+, K Han+, ... XW Bao*, & Zhao P*, D Chen*, 2024
Induction of Tumor Ferroptosis-Dependent Immunity via an Injectable Attractive Pickering Emulsion Gel, Dai XM, J Zhang, XW Bao, et al., 2023
An immunometabolism subtyping system identifies S100A9+ macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis, Bao X, Wang DY, Dai XM, et al., 2023
Molecular Subgroups of Intrahepatic Cholangiocarcinoma Discovered by Single-Cell RNA Sequencing-Assisted Multi-Omics Analysis, Bao X, Li Q, Chen J, et al., 2022
MS4A15 drives ferroptosis resistance through calcium-restricted lipid remodeling, Xin, S., Mueller, C., Pfeiffer, S., Kraft, V. A., Merl-Pham, J., Bao, X., ... & Schick, J. A., 2022
Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy, Bao X, Zhang H, Wu W, et al., 2020
Development and validation of a meta-learning-based multi-modal deep learning algorithm for detection of peritoneal metastasis, Zhang H, Zhu X, Li B, et al., 2022
Construction of TME and identification of crosstalk between malignant cells and macrophages by SPP1 in hepatocellular carcinoma, Liu, L., Zhang, R., Deng, J., Dai, X., Zhu, X., Fu, Q., ... & Bao, X., 2022
Enhanced radiotherapy efficacy and induced anti-tumor immunity in HCC by improving hypoxia microenvironment using oxygen microcapsules, Dai, X., Ruan, J., Guo, Y., Sun, Z., Liu, J., Bao, X., ... & Zhao, P., 2021
Depiction of the genomic and genetic landscape identifies CCL5 as a protective factor in colorectal neuroendocrine carcinoma, Chen, D., Bao, X., Zhang, R., Ding, Y., Zhang, M., Li, B., ... & Zhao, P., 2021
Characterization of Genomic Alterations in Colorectal Liver Metastasis and Their Prognostic Value, Bao, X., Wang, K., Liu, M., Li, B., Wang, H., Jin, K., ... & Xing, B., 2021
Identification and validation of hypoxia-derived gene signatures to predict clinical outcomes and therapeutic responses in stage I lung adenocarcinoma patients, Shi, R., Bao, X., Unger, K., Sun, J., Lu, S., Manapov, F., ... & Li, M., 2021
Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and aggressiveness in TNBC, Bao, X., Shi, R., Zhao, T., Wang, Y., Anastasov, N., Rosemann, M., & Fang, W., 2021
Nonsense-mediated decay factor SMG7 sensitizes cells to TNFα-induced apoptosis via CYLD tumor suppressor and the noncoding oncogene Pvt1, Yang, L., Kraft, V. A., Pfeiffer, S., Merl‐Pham, J., Bao, X., An, Y., ... & Schick, J. A., 2020
Tumor microenvironment characterization in head and neck squamous carcinoma reveals distinct genomic alterations and clinical outcomes, Shi R, Bao X, Sun J, et al., 2020
Extended in vitro culture of primary human mesenchymal stem cells downregulates Brca1‐related genes and impairs DNA double‐strand break recognition, Bao X, Wang J, Zhou G, et al., 2020
Establishment and validation of an individualized cell cycle process-related gene signature to predict cancer-specific survival in patients with bladder cancer, Shi R, Bao X, Rogowski P, et al., 2020
Mast cell‐based molecular subtypes and signature associated with clinical outcome in early‐stage lung adenocarcinoma, Bao X, Shi R, Zhao T, et al., 2020
GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling, Kraft V A N, Bezjian C T, Pfeiffer S, et al., 2019
A novel gene signature-based model predicts biochemical recurrence-free survival in prostate cancer patients after radical prostatectomy, Shi R, Bao X, Weischenfeldt J, et al., 2019
Development of a membrane lipid metabolism–based signature to predict overall survival for personalized medicine in ccRCC patients, Bao M, Shi R, Zhang K, Bao X., 2019
Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability, Hladik, D., Höfig, I., Oestreicher, U., Beckers, J., Matjanovski, M., Bao, X., ... & Rosemann, M., 2019
A novel 4-gene signature for overall survival prediction in lung adenocarcinoma patients with lymph node metastasis, Wang, Y., Zhang, Q., Gao, Z., Xin, S., Zhao, Y., Zhang, K., ... & Bao, X., 2019
A novel epigenetic signature for overall survival prediction in patients with breast cancer, Bao, X., Anastasov, N., Wang, Y., & Rosemann, M., 2019

Deep Learning High-Throughput Omics Tumor Spatial Distribution Tumor Heterogeneity Tumor-Associated Macrophages Immunotherapy Computational Biology Bioinformatics Cell Interaction Tumor Microenvironment

Jin Li - Fudan University

Yan Lu - Zhejiang University

Pengyuan Liu - Zhejiang University

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