Professor | Xuan Shao | Asia Growth Partners

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Name	Xuan Shao
Contact Information	shaoxuan@ioz.ac.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Xuan Shao

Contact Information

shaoxuan@ioz.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Chinese Academy of Sciences
Faculty	Institute of Zoology
Academic Background & Achievements	2006 - Bachelor's Degree: Hebei University 2014 - PhD in Science: Institute of Zoology, Chinese Academy of Sciences Achievement: Published 15 papers in journals like PNAS, Journal of Pineal Research
Work Experience	2021 - Present - Institute of Zoology, Chinese Academy of Sciences - Associate Researcher Member of the Reproductive Pathology Research Group
Awards	National Natural Science Foundation of China - General Program National Natural Science Foundation of China - Youth Science Fund Project

University/Lab Affiliation and Title

Chinese Academy of Sciences

Faculty

Institute of Zoology

Academic Background & Achievements

2006 - Bachelor's Degree: Hebei University
2014 - PhD in Science: Institute of Zoology, Chinese Academy of Sciences
Achievement: Published 15 papers in journals like PNAS, Journal of Pineal Research

Work Experience

2021 - Present - Institute of Zoology, Chinese Academy of Sciences - Associate Researcher
Member of the Reproductive Pathology Research Group

Awards

National Natural Science Foundation of China - General Program
National Natural Science Foundation of China - Youth Science Fund Project

Areas of Focus	Regulation of Pregnancy Adaptation Metabolism of Trophoblast Cells
Publications	Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta., Shao X#, Yang Y#, Liu Y#, Wang Y#, Zhao Y, Yu X, Liu J, Li YX, Wang YL., 2023 The mystery of the life tree: the placenta., Shao X#, Yu W#, Yang Y#, Wang F, Yu X, Wu H, Ma Y, Cao B, Wang YL., 2022 Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at mid-gestation highlights the defective impacts on fetal health., Chen J#, Du L#, Wang F#, Shao X#, Wang X, Yu W, Bi S, Chen D, Pan X, Zeng S, Huang L, Liang Y, Li Y, Chen R, Xue F, Li X, Wang S, Zhuang M, Liu M, Lin L, Yan H, He F, Yu L, Jiang Q, Xiong Z, Zhang L, Cao B, Wang YL, Chen D., 2022 Placental development and Pregnancy-Associated Diseases., Yu X#, Wu Hong#, Yang Y, Wang F, Wang YL, Shao X., 2022 Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia., Li G#, Wang Y#, Cao G#, Ma Y, Li YX, Zhao Y, Shao X, Wang YL., 2022 Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply., Shao X#, Cao G#, Chen D#, Liu J, Yu B, Liu M, Li YX, Cao B, Sadovsky Y, Wang YL., 2021 Quantitative chemoproteomics reveals O-GlcNAcylation of Cystathionine γ-lyase (CSE) represses trophoblast syncytialization., Liu J#, Shao X#, Qin W#, Yanling Zhang#, Dang F, Yang Q, Yu X, Li YX, Chen X, Wang C, Wang YL., 2021 Single-cell immune landscape of human recurrent miscarriage., Wang F#, Jia W#, Fan M#, Shao X#. Li Z, Liu Y, Ma Y, Shao X, Li YX, Li R, Tu Q, Wang YL., 2021 miR-210 regulates placental adaptation to maternal hypoxic stress during pregnancy., Bian X, Liu J, Yang Q, Liu Y, Jia W, Zhang X, Li YX, Shao X, Wang YL., 2021 Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation., Ma Y#, Yang Q#, Fan M#, Zhang L, Gu Y, Jia W, Li Z, Wang F, Li YX, Wang J, Li R, Shao X, Wang YL., 2020 Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids., Li Z#, Bian X#, Ma Y, Yang Q, Jia W, Liu J, Wang F, Liu M, Li YX, Shao X, Wang YL., 2020 Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia., Shao X#, Wang Y#, Liu Y#, Guo X, Li D, Huo R, Jia W, Cao G, Li YX, Liu M, Sha J, Zhao Y, Wang YL., 2019 Placental defects are involved in most gene mutations that cause embryonic and fetal death., Shao X, Tan C, Chen D, Wang YL., 2018 Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia., Shao X#, Liu Y#, Liu M, Wang Y, Yan L, Wang H, Ma L, Li YX, Zhao Y, Wang YL., 2017 MicroRNA-210 contributes to preeclampsia by down-regulating KCMF1., Luo R#, Shao X#, Xu P, Liu Y, Wang Y, Zhao Y, Liu M, Ji L, Li YX, Chang C, Qiao J, Peng C, Wang YL., 2014

Areas of Focus

Regulation of Pregnancy Adaptation
Metabolism of Trophoblast Cells

Publications

Orchestrated feedback regulation between melatonin and sex hormones involving GPER1-PKA-CREB signaling in the placenta., Shao X#, Yang Y#, Liu Y#, Wang Y#, Zhao Y, Yu X, Liu J, Li YX, Wang YL*., 2023
The mystery of the life tree: the placenta., Shao X#, Yu W#, Yang Y#, Wang F, Yu X, Wu H, Ma Y, Cao B*, Wang YL*., 2022
Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at mid-gestation highlights the defective impacts on fetal health., Chen J#, Du L#, Wang F#, Shao X#, Wang X, Yu W, Bi S, Chen D, Pan X, Zeng S, Huang L, Liang Y, Li Y, Chen R, Xue F, Li X, Wang S, Zhuang M, Liu M, Lin L, Yan H, He F, Yu L, Jiang Q, Xiong Z, Zhang L, Cao B*, Wang YL*, Chen D*., 2022
Placental development and Pregnancy-Associated Diseases., Yu X#, Wu Hong#, Yang Y, Wang F, Wang YL*, Shao X*., 2022
Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia., Li G#, Wang Y#, Cao G#, Ma Y, Li YX, Zhao Y*, Shao X*, Wang YL*., 2022
Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply., Shao X#, Cao G#, Chen D#, Liu J, Yu B, Liu M, Li YX, Cao B*, Sadovsky Y*, Wang YL*., 2021
Quantitative chemoproteomics reveals O-GlcNAcylation of Cystathionine γ-lyase (CSE) represses trophoblast syncytialization., Liu J#, Shao X#, Qin W#, Yanling Zhang#, Dang F, Yang Q, Yu X, Li YX, Chen X, Wang C*, Wang YL*., 2021
Single-cell immune landscape of human recurrent miscarriage., Wang F#, Jia W#, Fan M#, Shao X#. Li Z, Liu Y, Ma Y, Shao X, Li YX, Li R*, Tu Q*, Wang YL*., 2021
miR-210 regulates placental adaptation to maternal hypoxic stress during pregnancy., Bian X, Liu J, Yang Q, Liu Y, Jia W, Zhang X, Li YX, Shao X*, Wang YL*., 2021
Placental endovascular extravillous trophoblasts (enEVTs) educate maternal T-cell differentiation along the maternal-placental circulation., Ma Y#, Yang Q#, Fan M#, Zhang L, Gu Y, Jia W, Li Z, Wang F, Li YX, Wang J, Li R*, Shao X*, Wang YL*., 2020
Uterine Scarring Leads to Adverse Pregnant Consequences by Impairing the Endometrium Response to Steroids., Li Z#, Bian X#, Ma Y, Yang Q, Jia W, Liu J, Wang F, Liu M, Li YX, Shao X*, Wang YL*., 2020
Association of imbalanced sex hormone production with excessive procoagulation factor SerpinF2 in preeclampsia., Shao X#, Wang Y#, Liu Y#, Guo X, Li D, Huo R, Jia W, Cao G, Li YX, Liu M, Sha J, Zhao Y, Wang YL*., 2019
Placental defects are involved in most gene mutations that cause embryonic and fetal death., Shao X, Tan C, Chen D, Wang YL*., 2018
Testosterone Represses Estrogen Signaling by Upregulating miR-22: A Mechanism for Imbalanced Steroid Hormone Production in Preeclampsia., Shao X#, Liu Y#, Liu M, Wang Y, Yan L, Wang H, Ma L, Li YX, Zhao Y*, Wang YL*., 2017
MicroRNA-210 contributes to preeclampsia by down-regulating KCMF1., Luo R#, Shao X#, Xu P, Liu Y, Wang Y, Zhao Y, Liu M, Ji L, Li YX, Chang C, Qiao J, Peng C*, Wang YL*., 2014

Pregnancy Adaptation Regulation Trophoblast Metabolism Placenta Endocrine Mechanism Preeclampsia Diseases

Xueying Zhang - Chinese Academy of Sciences

Li Lei - Chinese Academy of Sciences

Hongmei Wang - Chinese Academy of Sciences

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