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Hua Cai
Basic Medical Sciences
Guangzhou Medical University
Guangdong
Language: Chinese, English
Antiviral
Innate Immunity
Drosophila
Mammals
Viral Components
Pattern Recognition Receptors
Evolution
Immune Response
Model Organisms
Research
Areas of Focus
- Study of antiviral innate immunity induced by the interaction of viral components with pattern recognition receptors using Drosophila and mammals as models
Academic Background & Achievements
- PhD: Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
Publications
- Two cGAS-like receptors induce Sting-dependent antiviral immunity in Drosophila melanogaster, Andreas Holleufer, Kasper Grønbjerg Winther, Hans Henrik Gad, Xianlong Ai, Yuqiang Chen, Lihua Li, Ziming Wei, Huimin Deng, Jiyong Liu, Ninna Ahlmann Frederiksen, Bine Simonsen, Line Lykke Andersen, Karin Kleigrewe, Louise Dalskov, Andreas Pichlmair, Hua Cai, Jean-Luc Imler, Rune Hartmann, 2021
- cGAS-like receptors control RNA sensing and 3’2’-cGAMP antiviral signaling in Drosophila, Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Cai H, Imler JL, Kranzusch P, 2021
- 2'3'-cGAMP triggers a STING- and NF-kappaB-dependent broad antiviral response in Drosophila, Cai, H., Holleufer, A., Simonsen, B., Schneider, J., Lemoine, A., Gad, H. H., Huang, J., Huang, J., Chen, D., Peng, T., Marques, J. T., Hartmann, R., Martins, N. E., and Imler, J. L., 2020
- cGAS-STING: insight on the evolution of a primordial antiviral signaling cassette, Hua Cai, Jean-Luc Imler, 2021
- cGAS-like receptor-mediated immunity: the insect perspective, Hua Cai, Carine Meignin & Jean-Luc Imler, 2022
- The Kinase IKKbeta Regulates a STING- and NF-kappaB-Dependent Antiviral Response Pathway in Drosophila, Goto, A., Okado, K., Martins, N., Cai, H., Barbier, V., Lamiable, O., Troxler, L., Santiago, E., Kuhn, L., Paik, D., Silverman, N., Holleufer, A., Hartmann, R., Liu, J., Peng, T., Hoffmann, J. A., Meignin, C., Daeffler, L., and Imler, J. L., 2018
- The cellular and viral circRNAome induced by respiratory syncytial virus infection, Wenxia Yao, Jinghui Pan, Zhaoyu Liu, Zhijie Dong, Min Liang, Shu Xia, Yao Xiao, Xiaodan Cai, Tao Peng, Xinke Zhou, Hua Cai, 2021
- Apolipoprotein M, identified as a novel hepatitis C virus (HCV) particle associated protein, contributes to HCV assembly and interacts with E2 protein, Cai, H., Yao, W., Huang, J., Xiao, J., Chen, W., Hu, L., Mai, R., Liang, M., Chen, D., Jiang, N., Zhou, L., Peng, T., 2020
- Cell-death-inducing DFFA-like Effector B Contributes to the Assembly of Hepatitis C Virus (HCV) Particles and Interacts with HCV NS5A, Cai, H., Yao, W., Li, L., Li, X., Hu, L., Mai, R., and Peng, T, 2016
- Endoplasmic Reticulum Stress Links Hepatitis C Virus RNA Replication to Wild-Type PGC-1alpha/Liver-Specific PGC-1alpha Upregulation, Wenxia Yao, Hua Cai, Xinlei Li, Ting Li, Longbo Hu, Tao Peng, 2014
Awards
- Guangzhou High-Level Talent - Outstanding Expert
- First Guangdong Association for Science and Technology Young Talent
- Returned Overseas Scholar
