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Jian Shi
Basic Medical Sciences
Southern Medical University
Guangdong
Language: Chinese, English
Breast Cancer
Drug Target
Drug Resistance
Transcriptional Regulation
Molecular Mechanisms
Cancer Progression
Therapeutic Targets
Brd4
Foxo3A
Akt Inhibitors
Areas of Focus
- Molecular mechanisms of breast cancer progression and drug resistance
Work Experience
- 2015-present - Southern Medical University - Professor, Doctoral Supervisor
Academic Background & Achievements
- Bachelor's Degree: Sichuan University
- Ph.D.: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
- Postdoctoral Research: Markey Cancer Center, University of Kentucky
- Published in top journals like Cancer Cell, Nature Communications, and Theranostics
Publications
- Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance, Fang Tai, Kunxiang Gong, Kai Song, Yanling He, Jian Shi, 2020
- Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer, Liu J, Duan Z, Guo W, Zeng L, Wu Y, Chen Y, Tai F, Wang Y, Lin Y, Zhang Q, He Y, Deng J, Stewart RL, Wang C, Lin PC, Ghaffari S, Evers BM, Liu S, Zhou MM, Zhou BP, Shi J, 2018
- Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1, Jingying Cao, Xin Wang, Tao Dai, Yuanzhong Wu, Meifang Zhang, Renxian Cao, Ruhua Zhang, Gang Wang, Rou Jiang, Binhua P. Zhou, Jian Shi, Tiebang Kang, 2018
- Disrupting the Interaction of BRD4 with Diacetylated Twist Suppresses Tumorigenesis in Basal-like Breast Cancer, Jian Shi, Yifan Wang, Lei Zeng, Yadi Wu, Jiong Deng, Qiang Zhang, Yiwei Lin, Junlin Li, Tiebang Kang, Min Tao, Elena Rusinova, Guangtao Zhang, Chi Wang, Haining Zhu, Jun Yao, Yi-Xin Zeng, B. Mark Evers, Ming-Ming Zhou, and Binhua P. Zhou, 2014
Awards
- Selected as Best of Cancer Cell 2014
- Recommendation by F1000Prime
