Professor | 石坚 | 数字化转型顾问

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Name

石坚

Contact Information

jianshismu@126.com

Language ability

中文, 英语

Province

广东

University/Lab Affiliation and Title	南方医科大学
Faculty	Basic Medical Sciences
Academic Background & Achievements	本科：四川大学博士：中国科学院上海生命科学研究院博士后研究：美国肯塔基大学Markey癌症中心在Cancer Cell, Nature Communications和Theranostics等国际著名期刊发表论文
Work Experience	2015年至今 - 南方医科大学 - 教授，博士生导师
Awards	2014年被评为Cancer Cell最佳 F1000Prime推荐

University/Lab Affiliation and Title

南方医科大学

Faculty

Basic Medical Sciences

Academic Background & Achievements

Work Experience

Awards

Areas of Focus	乳腺癌演进及药物抵抗的分子机制
Publications	由于BRD4/FOXD3/miR-548d-3p轴的丢失增强了JunD/RSK3信号，决定了BET抑制耐药性, Fang Tai, Kunxiang Gong, Kai Song, Yanling He, Jian Shi, 2020 靶向BRD4/FOXO3a/CDK6轴增强AKT抑制在腔型乳腺癌中的敏感性, Liu J, Duan Z, Guo W, Zeng L, Wu Y, Chen Y, Tai F, Wang Y, Lin Y, Zhang Q, He Y, Deng J, Stewart RL, Wang C, Lin PC, Ghaffari S, Evers BM, Liu S, Zhou MM, Zhou BP, Shi J, 2018 Twist通过转录上调ROR1促进基底样乳腺癌的肿瘤转移, Jingying Cao, Xin Wang, Tao Dai, Yuanzhong Wu, Meifang Zhang, Renxian Cao, Ruhua Zhang, Gang Wang, Rou Jiang, Binhua P. Zhou, Jian Shi, Tiebang Kang, 2018 破坏BRD4与二乙酰化Twist的相互作用抑制基底样乳腺癌的肿瘤发生, Jian Shi, Yifan Wang, Lei Zeng, Yadi Wu, Jiong Deng, Qiang Zhang, Yiwei Lin, Junlin Li, Tiebang Kang, Min Tao, Elena Rusinova, Guangtao Zhang, Chi Wang, Haining Zhu, Jun Yao, Yi-Xin Zeng, B. Mark Evers, Ming-Ming Zhou, and Binhua P. Zhou, 2014

Areas of Focus

乳腺癌演进及药物抵抗的分子机制

Publications

由于BRD4/FOXD3/miR-548d-3p轴的丢失增强了JunD/RSK3信号，决定了BET抑制耐药性, Fang Tai, Kunxiang Gong, Kai Song, Yanling He, Jian Shi, 2020
靶向BRD4/FOXO3a/CDK6轴增强AKT抑制在腔型乳腺癌中的敏感性, Liu J, Duan Z, Guo W, Zeng L, Wu Y, Chen Y, Tai F, Wang Y, Lin Y, Zhang Q, He Y, Deng J, Stewart RL, Wang C, Lin PC, Ghaffari S, Evers BM, Liu S, Zhou MM, Zhou BP, Shi J, 2018
Twist通过转录上调ROR1促进基底样乳腺癌的肿瘤转移, Jingying Cao, Xin Wang, Tao Dai, Yuanzhong Wu, Meifang Zhang, Renxian Cao, Ruhua Zhang, Gang Wang, Rou Jiang, Binhua P. Zhou, Jian Shi, Tiebang Kang, 2018
破坏BRD4与二乙酰化Twist的相互作用抑制基底样乳腺癌的肿瘤发生, Jian Shi, Yifan Wang, Lei Zeng, Yadi Wu, Jiong Deng, Qiang Zhang, Yiwei Lin, Junlin Li, Tiebang Kang, Min Tao, Elena Rusinova, Guangtao Zhang, Chi Wang, Haining Zhu, Jun Yao, Yi-Xin Zeng, B. Mark Evers, Ming-Ming Zhou, and Binhua P. Zhou, 2014

乳腺癌药物靶点药物抵抗转录调控分子机制癌症进展治疗靶点 Brd4 Foxo3A Akt抑制剂

尚永丰 - 北京大学

邵根泽 - 北京大学

刘秀萍 - 复旦大学

Area of Focus
癌基因 | 非编码Rna | 乳腺癌 | 多药耐药 | 侵袭 | 转移 | 分子机制 | Hscs | 静止 | 激活

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